Tanshinone I - ≥97% , CAS No.568-73-0

CAS: 568-73-0 Cat. No.: T118876 Fórmula: C₁₈H₁₂O₃ Peso molecular: 276.29 Número CE: 685-417-1 PubChem CID: 114917

GRADE & PURITY ≥97%

Synonyms

Tanshinone I, analytical standard | AKOS005613012 | NCGC00247624-02 | TanshinoneI | Tanshinone-I | 1,6-Dimethyl-phenanthro[1,2-b]furan-10,11-dione | 1,6-Dimethylphenanthro[1,2-b]furan-10,11-dione | 1,6-dimethylnaphtho[1,2-g]benzofuran-10,11-quinone | AS-6

Storage

Store at 2-8°C,Argon charged

Shipped In

Wet ice

Visão geral

Tanshinone I is a pigment isolated from the herbal medicine Salvia miltiorrhiza Bunge. Tanshinone I displays cytotoxicity against human macrophages and IFN-g production in KLH-primed lymph node cells.
A biochemical that displays cytotoxicity against IFN-g production in KLH-primed lymph node cells

Specifications

Sinónimos

Tanshinone I, analytical standard | AKOS005613012 | NCGC00247624-02 | TanshinoneI | Tanshinone-I | 1,6-Dimethyl-phenanthro[1,2-b]furan-10,11-dione | 1,6-Dimethylphenanthro[1,2-b]furan-10,11-dione | 1,6-dimethylnaphtho[1,2-g]benzofuran-10,11-quinone | AS-6

Especificações e pureza

≥97%

Condições de armazenamento de armazenamento

Store at 2-8°C,Argon charged

Enviado em

Wet ice

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥97%

Nomes e identificadores

Pubchem Sid

504756730

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504756730

Sorrisos canónicos

CC1=C2C=CC3=C(C2=CC=C1)C(=O)C(=O)C4=C3OC=C4C

IUPAC Name

1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dione

InChIKey

AIGAZQPHXLWMOJ-UHFFFAOYSA-N

INCHI

1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3

SMILES isoméricas

CC1=C2C=CC3=C(C2=CC=C1)C(=O)C(=O)C4=C3OC=C4C

WGK Alemanha

3

PubChem CID

114917

Peso molecular

276.29

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Classe Prenol lipids
      • Subclass Diterpenoids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Classe: Prenol lipids
• Subclass: Diterpenoids
• Intermediate Tree Nodes: Not available
• Direct Parent: Tanshinones, isotanshinones, and derivatives
• Alternative Parents: Phenanthrenes and derivatives Naphthofurans Naphthalenes O-quinones Aryl ketones Heteroaromatic compounds Furans Oxacyclic compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Tanshinone skeleton - Phenanthrene - Naphthofuran - Naphthalene - Aryl ketone - Quinone - O-quinone - Benzenoid - Heteroaromatic compound - Furan - Ketone - Oxacycle - Organoheterocyclic compound - Organic oxide - Organic oxygen compound - Organooxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as tanshinones, isotanshinones, and derivatives. These are a group of abietane-type norditerpenoid quinones.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

VDR Tclin Vitamin D receptor (26531 Activities)

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ACHE Tclin Acetylcholinesterase (18204 Activities)

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AKR1B1 Tclin Aldose reductase (1404 Activities)

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POLB Tchem DNA polymerase beta (23632 Activities)

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PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

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CES2 Tchem Carboxylesterase 2 (583 Activities)

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PTPN6 Tchem Protein-tyrosine phosphatase 1C (687 Activities)

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PTPN11 Tchem Protein-tyrosine phosphatase 2C (2297 Activities)

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CES1 Tchem Acyl coenzyme A:cholesterol acyltransferase (1029 Activities)

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TERT Tchem Telomerase reverse transcriptase (2428 Activities)

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PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)

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TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

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AGS (1999 Activities)

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MCF7 (126967 Activities)

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U373 MG (658 Activities)

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MIA PaCa-2 (5949 Activities)

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HCT-116 (91556 Activities)

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HepG2 (196354 Activities)

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KB (17409 Activities)

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MDA-MB-231 (73002 Activities)

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FEN1 Tchem Flap endonuclease 1 (12055 Activities)

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MGLL Tchem Monoglyceride lipase (1909 Activities)

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GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)

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POLK Tbio DNA polymerase kappa (8653 Activities)

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POLI Tchem DNA polymerase iota (116820 Activities)

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POLH Tchem DNA polymerase eta (21678 Activities)

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KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

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Liver (3974 Activities)

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KDM1A Tchem Lysine-specific histone demethylase 1 (3916 Activities)

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BRCA1 Tchem Breast cancer type 1 susceptibility protein (15908 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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PLC-PRF-5 (244 Activities)

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BLM Tchem Bloom syndrome protein (4248 Activities)

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GMNN Tbio Geminin (128009 Activities)

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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

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BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)

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ATXN2 Tbio Ataxin-2 (54410 Activities)

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USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

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RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (15528 Activities)

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CGA Tbio Glycoprotein hormones alpha chain (29278 Activities)

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HIF1A Tchem Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha (820 Activities)

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TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)

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EZH2 Tclin EZH2/SUZ12/EED complex (20 Activities)

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Hep 3B2 (2332 Activities)

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Alvos associados (não humanos)

Papain (844 Activities)

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Abcb1b P-glycoprotein 1 (174 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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SARS coronavirus 3C-like proteinase (333 Activities)

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Streptococcus (3973 Activities)

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Saccharomyces cerevisiae (19171 Activities)

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Plasmodium falciparum (966862 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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Streptococcus sp. 'group A' (3417 Activities)

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Luciferin 4-monooxygenase (66902 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Protease (18 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

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TGR Thioredoxin glutathione reductase (28579 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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ska Streptokinase A (5805 Activities)

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Rorc Nuclear receptor ROR-gamma (89407 Activities)

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fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

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NS1 Nonstructural protein 1 (33327 Activities)

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SARS-CoV-2 (38078 Activities)

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Mecanismos de ação

Propriedades químicas e físicas

• Índice de refração: 1.68
• Ponto de ebulição (°C): 474-522 °C
• Ponto de fusão (°C): 233-234℃
• Peso molecular: 276.300 g/mol
• XLogP3: 3.700
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 276.079 Da
• Monoisotopic Mass: 276.079 Da
• Topological Polar Surface Area: 47.300 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 471.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥97% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 568-73-0, the molecular formula is C18H12O3, and the molecular weight is 276.29 g/mol. InChIKey AIGAZQPHXLWMOJ-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.