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CFTR

DescriçãoCystic fibrosis transmembrane conductance regulator

Gene and Protein Information

Gene ID1080
Uniprot Accession IDs P13569 Q20BG8 Q20BH2 Q2I0A1 Q2I102 CFTR
Ensembl ID ENSP00000003084
Symbol ABCC7 CF MRP7 ABC35 ABCC7 CFTR/MRP TNR-CFTR dJ760C5.1
FamilyBelongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
Sequence
MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNomeNúmero de identificação fiscalOther Gene IDSources
Chimp463674CFTRcystic fibrosis transmembrane conductance regulator9598Inparanoid, OMA, EggNOG
Macaque574346CFTRcystic fibrosis transmembrane conductance regulator9544Inparanoid, OMA, EggNOG
Mouse12638Cftrcystic fibrosis transmembrane conductance regulator10090MGI:88388Inparanoid, OMA, EggNOG
Rat24255Cftrcystic fibrosis transmembrane conductance regulator10116RGD:2332Inparanoid, OMA
Dog492302CFTRcystic fibrosis transmembrane conductance regulator9615VGNC:39180Inparanoid, OMA, EggNOG
Horse100071259CFTRcystic fibrosis transmembrane conductance regulator9796VGNC:16468Inparanoid, OMA, EggNOG
Cow281067CFTRcystic fibrosis transmembrane conductance regulator9913VGNC:50053Inparanoid, OMA, EggNOG
Pig403154CFTRcystic fibrosis transmembrane conductance regulator9823Inparanoid, OMA, EggNOG
Opossum100014119CFTRcystic fibrosis transmembrane conductance regulator13616Inparanoid, OMA, EggNOG
Anole lizard100559531cftrcystic fibrosis transmembrane conductance regulator28377Inparanoid, OMA, EggNOG
Xenopus100486085cftrcystic fibrosis transmembrane conductance regulator8364XB-GENE-853972Inparanoid, OMA, EggNOG
Zebrafish559080cftrcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)7955ZDB-GENE-050517-20Inparanoid, OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    transporter    /    ATP-binding cassette (ABC) transporter    /    Cystic fibrosis transmembrane conductance regulator
DTO Classes
protein    /    Ion channel    /    ABCC family    /    CFTR transporter subfamily    /    Cystic fibrosis transmembrane conductance regulator

Associated Recombinant Proteins

NomeSpecification and purityExpression systemProtein labelDisponibilidadeVer Detalhes

Associated Antibodies

NomeSpecificationsSpecies reactivityAplicaçãoDisponibilidadeVer Detalhes

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NomeDirect Associated TargetsDisease TypeMondoid

      Bibliography

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