TC-DAPK 6 - ≥98% , CAS No.315694-89-4

CAS: 315694-89-4 Cat. No.: T646454 Fórmula: C₁₇H₁₂N₂O₂ Peso molecular: 276.29 PubChem CID: 5676111

GRAU & PUREZA ≥98%

Synonyms

EX-A2167 | Z56820688 | EN300-260619 | AC-35960 | EN300-7536106 | 2-(2-phenylethenyl)-4-[(pyridin-3-yl)methylidene]-4,5-dihydro-1,3-oxazol-5-one | TC-DAPK-6 | (E)-4-(pyridin-3-ylmethylene)-2-((E)-styryl)oxazol-5(4H)-one | HY-15513 | 4-(pyridin-3-ylmethylen

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor ( IC 50 =69 and 225 nM against DAPK1 and DAPK3 , respectively, with 10 μM ATP).

In Vitro

TC-DAPK 6 is found to be the most potent Death-associated protein kinase (DAPK) inhibitor with enzyme selectivity. When assayed with 10 μM ATP, the IC 50 values for DAPK1 and DAPK3 are 69 and 225 nM, respectively. TC-DAPK 6 also inhibits p70S6K (1 μM < IC 50 < 10 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 69 nM (DAPK1), 225 nM (DAPK3)

Especificações

Sinónimos

EX-A2167 | Z56820688 | EN300-260619 | AC-35960 | EN300-7536106 | 2-(2-phenylethenyl)-4-[(pyridin-3-yl)methylidene]-4,5-dihydro-1,3-oxazol-5-one | TC-DAPK-6 | (E)-4-(pyridin-3-ylmethylene)-2-((E)-styryl)oxazol-5(4H)-one | HY-15513 | 4-(pyridin-3-ylmethylen

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor ( IC 50 =69 and 225 nM against DAPK1 and DAPK3 , respectively, with 10 μM ATP).

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%

Nomes e identificadores

Sorrisos canónicos

C1=CC=C(C=C1)C=CC2=NC(=CC3=CN=CC=C3)C(=O)O2

IUPAC Name

(4E)-2-[(E)-2-phenylethenyl]-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5-one

InChIKey

GFGMISOSPOPSHN-QCTDOKRBSA-N

INCHI

1S/C17H12N2O2/c20-17-15(11-14-7-4-10-18-12-14)19-16(21-17)9-8-13-5-2-1-3-6-13/h1-12H/b9-8+,15-11+

SMILES isoméricas

C1=CC=C(C=C1)/C=C/C2=N/C(=C/C3=CN=CC=C3)/C(=O)O2

PubChem CID

5676111

Peso molecular

276.29

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Classe Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Classe: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives
• Direct Parent: Alpha amino acids and derivatives
• Alternative Parents: Styrenes 4-Hydrocarbylideneazlactones Pyridines and derivatives Heteroaromatic compounds Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Monocarboxylic acids and derivatives Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Alpha-amino acid or derivatives - Styrene - 4-hydrocarbylideneazlactone - Monocyclic benzene moiety - Pyridine - Benzenoid - Oxazoline - Heteroaromatic compound - Monocarboxylic acid or derivatives - Oxacycle - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organoheterocyclic compound - Azacycle - Organic oxide - Organopnictogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Organonitrogen compound - Aromatic heteromonocyclic compound
• Descrição: This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propriedades químicas e físicas

• Solubilidade: DMSO : 18.67 mg/mL (67.57 mM; Need ultrasonic and warming)
• Peso molecular: 276.290 g/mol
• XLogP3: 2.900
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 276.09 Da
• Monoisotopic Mass: 276.09 Da
• Topological Polar Surface Area: 51.600 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 473.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 1

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 315694-89-4, the molecular formula is C17H12N2O2, and the molecular weight is 276.29 g/mol. InChIKey GFGMISOSPOPSHN-QCTDOKRBSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.