Tempol - 10mM in DMSO , CAS No.2226-96-2
Em stock
SKU
T407895
Membrane permeable superoxide scavenger. SOD mimetic.
Information
Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.
In vitro
Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. [1] Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. [2]
In vivo
Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. [3] Tempol prevents cerebral vessel remodeling in hypertensive rats. [4] Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. [5] Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. [6]
Cell Data
cell lines：
Concentrations：', 'Concentrations': '
Incubation Time：
Powder Purity:
Mais informação
| CAS | 2226-96-2 | |
|---|---|---|
| Concentração | 10mM in DMSO | |
| Especificações e pureza | 10mM in DMSO | |
| Condições de armazenamento de armazenamento | Store at -80°C | |
| Enviado em | Dry ice packs + Cold packs | |
| Product Description | Information Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2. Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. [1] Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. [2] In vivo Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. [3] Tempol prevents cerebral vessel remodeling in hypertensive rats. [4] Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. [5] Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. [6] cell lines： Concentrations：', 'Concentrations': ' | 0.05–1.6 mM Incubation Time： Powder Purity: |
| Número CE | 218-760-9 |
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