Tetracosactide acetate - ≥99% , CAS No.60189-34-6

CAS: 60189-34-6 Cat. No.: T650640 Fórmula: C₁₃₆H₂₁₀N₄₀O₃₁S.xC₂H₄O₂ Peso molecular: 2933.446005 Número CE: 692-445-8 PubChem CID: 87126289

GRADE & PURITY ≥99%

Synonyms

Tetracosactrin acetate | SCHEMBL563374

Storage

Protected from light,Argon charged,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Tetracosactide acetate is a synthetic peptide stimulating the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis.

Form:Solid

Specifications

Sinónimos

Tetracosactrin acetate | SCHEMBL563374

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

Tetracosactide acetate is a synthetic peptide stimulating the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoi

Condições de armazenamento de armazenamento

Protected from light,Argon charged,Desiccated,Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥99%

Nomes e identificadores

Sorrisos canónicos

CC(C)C(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CC8=CNC=N8)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(CC9=CC=C(C=C9)O)NC(=O)C(CO)N.CC(=O)O

IUPAC Name

acetic acid;(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]acetyl]amino]hexanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxylic acid

InChIKey

XDSGCNRPXJYVQS-GLMYKROOSA-N

INCHI

1S/C136H210N40O31S.C2H4O2/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79;1-2(3)4/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151);1H3,(H,3,4)/t86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,110-,111-;/m0./s1

SMILES isoméricas

CC(C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CC8=CNC=N8)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC9=CC=C(C=C9)O)NC(=O)[C@H](CO)N.CC(=O)O

PubChem CID

87126289

Peso molecular

2933.446005

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic Polymers
    • Classe Polypeptides

• Kingdom: Organic compounds
• Superclass: Organic Polymers
• Classe: Polypeptides
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Polypeptides
• Alternative Parents: Peptides Tyrosine and derivatives Arginine and derivatives Phenylalanine and derivatives Histidine and derivatives Glutamic acid and derivatives Methionine and derivatives Valine and derivatives N-acyl-L-alpha-amino acids Proline and derivatives Alpha amino acid amides Serine and derivatives Tryptamines and derivatives 3-alkylindoles Amphetamines and derivatives Pyrrolidinecarboxamides Pyrrolidine carboxylic acids N-acylpyrrolidines Imidazolyl carboxylic acids and derivatives 1-hydroxy-2-unsubstituted benzenoids Substituted pyrroles N-acyl amines Dicarboxylic acids and derivatives Heteroaromatic compounds Tertiary carboxylic acid amides Guanidines Amino acids Secondary carboxylic acid amides Dialkylthioethers Carboxylic acids Carboximidamides Azacyclic compounds Sulfenyl compounds Hydrocarbon derivatives Imines Carbonyl compounds Monoalkylamines Organic oxides Primary alcohols
• Molecular Framework: Not available
• Substituents: Polypeptide - Alpha peptide - Tyrosine or derivatives - Phenylalanine or derivatives - Arginine or derivatives - Histidine or derivatives - Glutamic acid or derivatives - Methionine or derivatives - N-acyl-alpha amino acid or derivatives - N-acyl-alpha-amino acid - Valine or derivatives - Proline or derivatives - N-acyl-l-alpha-amino acid - Alpha-amino acid amide - Triptan - Serine or derivatives - Amphetamine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - 3-alkylindole - Indole or derivatives - Indole - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - N-acylpyrrolidine - Pyrrolidine carboxylic acid - Imidazolyl carboxylic acid derivative - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Fatty amide - Substituted pyrrole - Dicarboxylic acid or derivatives - Monocyclic benzene moiety - N-acyl-amine - Fatty acyl - Benzenoid - Azole - Heteroaromatic compound - Imidazole - Tertiary carboxylic acid amide - Pyrrolidine - Pyrrole - Amino acid or derivatives - Secondary carboxylic acid amide - Amino acid - Carboxamide group - Guanidine - Thioether - Carboximidamide - Sulfenyl compound - Dialkylthioether - Carboxylic acid derivative - Organoheterocyclic compound - Carboxylic acid - Azacycle - Primary amine - Organic nitrogen compound - Organic oxygen compound - Imine - Primary aliphatic amine - Carbonyl group - Hydrocarbon derivative - Alcohol - Organic oxide - Organooxygen compound - Organosulfur compound - Amine - Organonitrogen compound - Primary alcohol - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Application Protocols

Validated, item-specific application protocols are not provided for this product.

• Tested applications for this listing: Not specified for this item; refer to CoA/Spec Sheet.

General research guidance (literature/practice)

• Cell-based GPCR assays: Prepare fresh working dilutions in assay buffer; include low carrier protein to mitigate adsorption; measure cAMP accumulation or reporter readouts after defined incubation times per your platform.
• Binding assays: Use radioligand or fluorescence-based competitive binding with appropriate controls; confirm receptor expression and non-specific binding windows.
• Analytics: For HPLC/LC–MS, use gradients compatible with peptides (e.g., water/acetonitrile with 0.05–0.1% acid modifier). Monitor at 214/220 nm and 280 nm.

Please develop and validate protocols under your laboratory conditions.

Biological Roles

Tetracosactide is the synthetic 1–24 amino acid fragment of adrenocorticotropic hormone (ACTH), derived from the proopiomelanocortin (POMC) precursor.

• Endogenous context (literature/general)
  • ACTH binds melanocortin receptors, with MC2R as the canonical adrenal receptor, activating Gs–adenylyl cyclase–cAMP signaling that regulates steroidogenic enzyme expression.
  • The N‑terminal 1–24 region retains full biological activity at MC2R; the C‑terminal region of full-length ACTH contributes to stability and receptor interactions in some contexts.
• Structural features relevant to function
  • The HFRW motif (His–Phe–Arg–Trp) is conserved across melanocortins and critical for receptor recognition; basic residues (Lys/Arg) contribute to binding and aqueous solubility.
• Experimental relevance
  • Widely used as a standardized agonist to interrogate receptor pharmacology, downstream signaling (cAMP accumulation, PKA activation), and transcriptional responses in steroidogenic cell models.

Note: The above describes biological function in research systems. This product is supplied strictly for research use only and is not intended for diagnostic or therapeutic use.

Buffer Applications

This product is a bioactive peptide, not a buffering agent. It does not define a useful buffer system on its own.

• Practical note
  • Dissolve and use tetracosactide acetate in appropriate biological buffers (e.g., PBS, HEPES, or saline) selected for your assay. Maintain mildly acidic to neutral pH to limit peptide degradation. See Solvent Selection and Storage & Reconstitution for guidance on preparing working solutions.

Green Alternatives

Peptide reagents like tetracosactide acetate are typically supplied lyophilized and used in aqueous media, aligning well with green chemistry principles by avoiding volatile organic solvents.

• Greener handling strategies (general)
  • Prefer water or dilute acetic acid for dissolution rather than DMF/DMSO where assay design allows.
  • Use minimal solvent volumes and prepare concentrated stocks to reduce waste; filter-sterilize rather than autoclaving to avoid degradation.
  • Work under inert gas to extend solution life, reducing the need for repeated preparations.

Comparison of solvent choices (general)

• Water/Acetate buffer: Renewable, low-toxicity, minimal environmental impact; best for stability.
• DMSO: Effective co-solvent but with higher environmental and disposal burdens; reserve for cases requiring high-concentration stocks.

Tradeoffs

• Aqueous systems support greener workflows but may limit maximum concentration and shelf-life; DMSO can enhance solubility at the cost of potential assay interference and waste management considerations.

Waste and disposal

• Aqueous peptide solutions are typically disposed per institutional guidelines for non-hazardous biological chemicals. Avoid chlorinated solvent use; segregate any organic solvent waste generated during analytics or cleaning.

Pharmaceutical Uses

No excipient or formulation-grade details are provided for this item, and it is supplied for research use only.

• Status for this catalog item
  • Grade/purity and pharmacopeial status: Not specified for this item; refer to CoA/Spec Sheet.
• General context (literature/industry)
  • Cosyntropin (tetracosactide) is known in the pharmaceutical field as a synthetic ACTH(1–24) peptide; when manufactured under appropriate GMP conditions it may serve as an active ingredient. This listing does not imply suitability for clinical or diagnostic use.
• Research formulation considerations (general)
  • For in vitro work, prepare sterile-filtered aqueous stocks, verify concentration by A280 or amino acid analysis if needed, and assess adsorption to labware at low concentrations.

For any use beyond basic research, specialized quality, documentation, and regulatory compliance are required and are outside the scope of this product.

Physical Properties

Item-specific physico-chemical specifications are not provided for this product.

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight, molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
• Melting point/decomposition: Peptides typically do not exhibit a sharp melting point and decompose on heating (general/literature guidance).
• Solubility (general, literature)
  • High aqueous solubility in water or dilute acids (e.g., 1–10 mM in water, 0.1% acetic acid) is typical for basic peptides; actual solubility depends on counterion content and lyophilizate composition.
  • Poor solubility expected in nonpolar organic solvents; miscible in water, saline, and many biological buffers.
• pH behavior (general, literature)
  • Strongly basic character due to multiple Lys/Arg residues; solutions are typically stable in mildly acidic to neutral pH. Avoid high pH which can promote deamidation and racemization.
• LogP, refractive index, density: Not typically defined for peptides; Not specified for this item.
• UV/Vis (general, literature)
  • Peptide shows absorbance due to Tyr and Trp side chains (λmax ~280 nm; qualitative); useful for concentration estimates using A280. Extinction coefficients depend on exact composition and counterion content.

For definitive specifications and analytical values, consult the product’s CoA/Spec Sheet.

Quality and Grades

• Item-specific grade/purity: Not specified for this item; refer to CoA/Spec Sheet.
• Typical peptide quality descriptors (general guidance)
  • Crude: minimal post-synthesis cleanup; variable purity; used for method development.
  • Desalted: low-molecular impurities reduced; counterions standardized (often acetate or TFA replaced by acetate).
  • Purified (e.g., >90–98% by HPLC): suitable for bioassays. Reported purity is typically based on analytical RP-HPLC at 214/220 nm and MS identity confirmation.
  • Counterion form: Acetate is frequently chosen to reduce TFA-related assay interference; the acetate content can influence mass and solubility.
• Documentation to expect
  • CoA should provide peptide content (%), purity by HPLC, identity by MS, residual solvents/reagents profile, water content (Karl Fischer), and counterion analysis when applicable. If such details are required for your application, request the current CoA prior to use.
• Stabilizers/additives
  • Not specified for this item; refer to CoA/Spec Sheet. Many peptide products are supplied lyophilized without excipients; others may include mannitol or salts to aid handling—verify on CoA.

Select the appropriate grade based on assay sensitivity (receptor binding, signaling assays) and regulatory context (research only for this item).

Reaction and Applications

This product is a bioactive peptide reagent rather than a small-molecule building block. Its primary uses are in biochemical and cell-based research.

• Research applications (literature/general)
  • Reference agonist for melanocortin receptor studies, especially MC2R (ACTH receptor), to probe cAMP signaling and steroidogenic pathways in adrenal-derived cell systems.
  • Positive control in GPCR assay development, receptor binding, β-arrestin recruitment, and downstream kinase activation profiling.
  • Tool compound to examine POMC-derived peptide biology, receptor selectivity, and structure–activity relationships via truncations or analog substitution.
• Analytical applications
  • Calibration/standard in LC–MS peptide method development; system suitability for RP-HPLC at 214/220 nm and 280 nm due to Tyr/Trp chromophores.
• Practical tips (general)
  • Prepare fresh, oxygen-minimized solutions; protect from light to preserve Trp and Tyr.
  • Use low-binding plastics and include carrier protein (e.g., 0.1% BSA) when working at low nanomolar concentrations to minimize adsorption losses (validate for your assay).
  • Aliquot upon first reconstitution to avoid freeze–thaw cycles that can cause aggregation or hydrolysis.

No synthetic reaction chemistry (e.g., cross-coupling, Grignard) is typically applicable to this peptide reagent.

Reaction Conditions

Conventional organic reaction condition guidance is not applicable. The following outlines general conditions for handling this peptide in research assays (literature/practice guidance; not item-specific specifications):

• Dissolution
  • Prefer water or 0.1–1.0% acetic acid. For difficult cases, dissolve first in a minimal volume of sterile water or DMSO, then dilute with buffer (e.g., PBS, HEPES). Gentle mixing; avoid vigorous vortexing to limit foaming and air exposure.
• Concentration and filtration
  • Prepare concentrated stock (e.g., 0.1–5 mM depending on solubility), then sterile-filter through 0.22 μm low-protein-binding membranes if sterility is required. Verify concentration by A280 using sequence-derived extinction coefficients (literature-derived).
• Stability
  • Work at pH 4.5–7.4 when possible. Avoid prolonged exposure to >25 °C. Protect from light; sparge with inert gas to minimize oxidation. Include carrier protein (e.g., 0.1% BSA) to reduce adsorption at low concentrations if compatible with the assay.
• Storage of solutions
  • Aliquot into single-use portions; store at −20 °C to −80 °C. Minimize freeze–thaw cycles.

These are general literature practices for peptide reagents. Optimize conditions empirically for your specific assay and consult the SDS/CoA for product-specific directions if available.

Safety and Handling

• Regulatory/SDS
  • GHS classification, signal word, pictograms, and H-statements: Not specified for this item; refer to the SDS for authoritative safety information.
  • Research Use: For research use only.
• General hazards (peptide materials; literature/practice)
  • Low volatility solid; primary risks are dust inhalation, dermal/ocular exposure, and potential sensitization to bioactive peptides.
  • Bioactivity: Tetracosactide is a potent ACTH(1–24) analog; avoid accidental exposure and ingestion. Handle with care in a chemical fume hood or biosafety cabinet as appropriate.
• PPE and engineering controls (best practice)
  • Lab coat, nitrile gloves, safety glasses; weigh in a ventilated enclosure to minimize aerosolization.
  • Use dedicated tools and clean surfaces to prevent cross-contamination in bioassays.
• Incompatibilities and stability (general)
  • Protect from light and oxygen; the Met and Trp residues are oxidation-sensitive. Avoid strong oxidizers and prolonged exposure to basic solutions. Minimize repeated freeze–thaw cycles.
• First aid (overview; defer to SDS)
  • Inhalation: Move to fresh air, seek medical advice. Skin/eye contact: Rinse with water for several minutes; remove contaminated clothing; obtain medical attention if irritation persists. Ingestion: Rinse mouth; do not induce vomiting; seek medical attention.

Always consult the product SDS for substance-specific hazards, spill response, and disposal guidance.

Solvent Selection

Tetracosactide acetate is a highly basic, water-compatible peptide. Solvent choice should maximize stability while achieving complete dissolution.

• Polarity and miscibility (general)
  • Strongly hydrophilic; readily dissolves in water, saline, or mildly acidic aqueous media. Poorly soluble in nonpolar solvents. DMSO can be used for concentrated stocks if needed, followed by dilution into buffer.
• Recommended solvent systems (literature/practice)
  • Water or 0.1–1.0% acetic acid for initial dissolution; PBS or isotonic saline after dissolution if required by the assay.
  • Avoid high-pH buffers (base-catalyzed deamidation/epimerization) and oxidizing environments (Met/Trp oxidation). Consider adding oxygen scavengers or degassing for sensitive applications.
• Handling tips
  • Bring vial to room temperature in a desiccator before opening to prevent moisture condensation.
  • If foaming or incomplete dissolution occurs, gentle swirling is preferred over vortexing to limit shear and air exposure.

Comparison (general)

• Water/acetic acid: Best solubility and stability, minimal assay interference.
• DMSO: Enables higher-concentration stocks; may affect some bioassays—validate final DMSO percentage.
• Basic buffers: Not recommended due to chemical lability of peptide bonds and side chains.

Storage and Reconstitution

Item-specific storage conditions (as provided):

• Protect from light; Argon charged; Desiccated; Store at −80 °C.
• Shipped on dry ice packs + cold packs.

Reconstitution (general guidance; not item-specific specifications)

• Equilibrate the sealed vial to room temperature in a desiccated environment before opening to avoid moisture condensation.
• Reconstitute in sterile water or 0.1–1.0% acetic acid to a convenient stock concentration. If needed, prepare a minimal DMSO concentrate before dilution into buffer.
• Gently mix until dissolved; avoid vigorous agitation. If particulate remains, brief sonication or warming to room temperature can help. Sterile-filter through a low-protein-binding 0.22 μm filter if sterility is required.

Aliquoting and storage of solutions (general)

• Dispense single-use aliquots into low-binding tubes; purge headspace with inert gas when feasible. Store at −80 °C for long-term, avoiding repeated freeze–thaw cycles. Record preparation date and conditions.

Stability notes (general)

• Avoid alkaline pH and oxidative conditions to limit deamidation and Met/Trp oxidation. Use amber containers or foil wrapping to protect from light.

For definitive product-specific instructions (e.g., exact solubility, stabilizers, shelf-life), consult the CoA/Spec Sheet.

Structure and Identity

Tetracosactide acetate (cosyntropin acetate) is a synthetic polypeptide corresponding to the N‑terminal 1–24 fragment of human adrenocorticotropic hormone (ACTH), typically isolated as an acetate salt.

• Item-specific identifiers
  • CAS: 60189-34-6
  • CID: 87126289
  • InChIKey: 415289 (as provided)
  • SMILES: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
• Structural features (general, literature)
  • Peptide sequence: Ser–Tyr–Ser–Met–Glu–His–Phe–Arg–Trp–Gly–Lys–Pro–Val–Gly–Lys–Lys–Arg–Arg–Pro–Val–Lys–Val–Tyr–Pro (ACTH1–24).
  • Functional groups: multiple amides (peptide bonds), phenol (Tyr), indole (Trp), thioether (Met), imidazole (His), guanidinium (Arg), primary amines (Lys), carboxamide termini. Acetate counterions balance protonated basic residues.
  • Topology: linear 24‑mer with amphiphilic character and multiple cationic side chains; no disulfides.
  • Stereochemistry: all L‑amino acids (literature, typical for synthetic ACTH1–24).
• 2D description in words (general)
  • A linear chain of 24 L‑residues bearing aromatic rings (Tyr, Phe, Trp), basic side chains (Lys, Arg), one sulfur-containing Met, and polar residues, terminated by standard peptide termini. Counteranions are acetate.

Synthetic Utility

As a finished 24‑mer peptide, tetracosactide acetate is not typically used as a small-molecule synthon. Its utility is primarily as a biochemical probe. Nevertheless, it can be integrated into synthetic and analytical workflows as follows (general/literature):

• Standard/benchmark
  • Use as a system suitability standard for RP‑HPLC and LC–MS peptide analytics; retention and ionization behaviors aid method qualification.
• Probe/ligand in chemical biology
  • Ligand for melanocortin receptors in target validation, high-content screening, or bias signaling studies.
• Derivatization studies
  • Site-selective modifications (e.g., N‑terminal acylation, lysine conjugation, fluorescent labeling on Tyr) can be explored to map structure–activity relationships or to generate reporter conjugates. Protecting-group strategies and gentle conditions are required to preserve sensitive residues (Met, Trp).
• Enzymology substrate
  • Substrate for protease specificity profiling or oxidative/stability stress mapping, leveraging LC–MS to characterize cleavage and modification sites.

For classical organic synthesis or cross-coupling chemistry, this reagent is not applicable; consult small-molecule building blocks instead.

Target Specificity

Item-specific target or assay validation data are not provided for this product.

• Target details for this listing: Not specified for this item; refer to CoA/Spec Sheet.

General research context (literature)

• Tetracosactide (ACTH1–24) is a potent agonist of the melanocortin receptor MC2R and may engage other melanocortin subtypes with varying potency/efficacy depending on system context. Verify receptor expression and assay sensitivity in your model prior to use.

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?80 °C, protected from light, desiccated, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 60189-34-6, the molecular formula is C136H210N40O31S?x(C2H4O2), and the molecular weight is 2933.446005 g/mol. InChIKey XDSGCNRPXJYVQS-GLMYKROOSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.