Tipepidine hydrochloride - ≥99% , CAS No.1449686-84-3

CAS: 1449686-84-3 Cat. No.: T646944 Fórmula: C₁₅H₁₈ClNS₂ Peso molecular: 311.89 PubChem CID: 138991192

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Visão geral

Tipepidine hydrochloride reversibly inhibits dopamine (DA) D 2 receptor-mediated GIRK currents (I DA(GIRK) ) with an IC 50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect .

In Vivo

Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats weighting 150-240 g (5-7 weeks old)Dosage: 10, 20 and 40 mg/kg Administration: I.p.; 0.5, 5, 23 hours Result: Decreased the immobility time in the forced swimming test in ACTH-treated rats.

Form:Solid

IC50& Target:IC50: 7.0 μM (dopamine D 2 receptor)

Specifications

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

Tipepidine hydrochloride reversibly inhibits dopamine (DA) D 2 receptor-mediated GIRK currents (I DA(GIRK) ) with an IC 50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron. Tipepidine hydrochloride, a non-narcotic antitu

Condições de armazenamento de armazenamento

Store at 2-8°C,Desiccated

Enviado em

Wet ice

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥99%

Nomes e identificadores

Sorrisos canónicos

CN1CCCC(=C(C2=CC=CS2)C3=CC=CS3)C1.Cl

IUPAC Name

3-(dithiophen-2-ylmethylidene)-1-methylpiperidine;hydrochloride

InChIKey

MICLPSFJJVIDJE-UHFFFAOYSA-N

INCHI

1S/C15H17NS2.ClH/c1-16-8-2-5-12(11-16)15(13-6-3-9-17-13)14-7-4-10-18-14;/h3-4,6-7,9-10H,2,5,8,11H2,1H3;1H

PubChem CID

138991192

Peso molecular

311.89

Propriedades químicas e físicas

• Solubilidade: DMSO : 41.67 mg/mL (133.60 mM; Need ultrasonic) H2O : 3.33 mg/mL (10.68 mM; Need ultrasonic)
• Peso molecular: 311.900 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 311.057 Da
• Monoisotopic Mass: 311.057 Da
• Topological Polar Surface Area: 59.700 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 308.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Perguntas frequentes

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1449686-84-3, the molecular formula is C15H18ClNS2, and the molecular weight is 311.89 g/mol. InChIKey MICLPSFJJVIDJE-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.