TP-10 - 10mM in DMSO , CAS No.898563-00-3

CAS: 898563-00-3 Cat. No.: T656231 Fórmula: C₂₆H₁₉F₃N₄O Peso molecular: 460.45

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

TP-10 is a selective PDE10A inhibitor with an IC 50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC 50 s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy

In Vitro

TP-10 (10 μg /mL; 24 h) affects total reactive oxygen species in human brain-derived cells (U-87 MG). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: U-87 MG cells Concentration: 10 μg/ml Incubation Time: 24 hours Result: Decreased the total number of ROS-positive cells and showed no toxic effects to U-87 MG cells.

In Vivo

TP-10 (0.1-10 mg/kg; i.h. once) shows an effect on cyclic nucleotides. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male CD ratsDosage: 0.1, 0.32, 1.0, 3.2 and 10 mg/kg Administration: Subcutaneous injection; 0.1-10 mg/kg once Result: Dose- and time-dependently increased the levels of both cGMP and cAMP in striatal of mice. Increased pCREB-LI level first and returned to basal levels after injected for 3 hours at a dose of 3.2 mg/kg.

IC50& Target:IC50: 0.8 nM (PDE10A), 31.72 μg/mL (DPPH), 16.04 μg/mL (CUPRAC)

Specifications

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

TP-10 is a selective PDE10A inhibitor with an IC 50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC 50 s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Nomes e identificadores

• Peso molecular: 460.45

Perguntas frequentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 898563-00-3, the molecular formula is C26H19F3N4O, and the molecular weight is 460.45 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.