Trelagliptin succinate - 10mM in DMSO , Dipeptidyl peptidase IV inhibitor, CAS No.1029877-94-8, Dipeptidyl peptidase IV inhibitor

CAS: 1029877-94-8 Cat. No.: T420397 Fórmula: C₁₈H₂₀FN₅O₂.C₄H₆O₄ Peso molecular: 475.47 PubChem CID: 44183569

GRAU & PUREZA 10mM in DMSO

Synonyms

AC-28020 | SYR 472 | D10179 | Q27258374 | SYR 111472 succinate | TRELAGLIPTIN SUCCINATE [JAN] | 1029877-94-8 | F20669 | SCHEMBL878010 | AS-10248 | Trelagliptin (succinate) | TRELAGLIPTIN SUCCINATE [WHO-DD] | WLN: Q1YQ1OR DG | SYR-472 succinate | Butanedio

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Trelagliptin succinate Trelagliptin succinate (SYR472) is a dipeptidyl peptidase IV (DPP-4) inhibitor which is used as a new long-acting drug for once-weekly treatment of type 2 diabetes mellitus (DM).

Targets

DPP-4 (Cell-free assay) 4 nM

In vitro

Trelagliptin is selective over other related DPP enzymes, P450 enzymes and hERG channel. It exhibits approximately 4- and 12-fold more potent inhibition against human dipeptidyl peptidase-4 than alogliptin and sitagliptin, respectively, and >10,000-fold selectivity over related proteases including dipeptidyl peptidase-8 and dipeptidyl peptidase-9. Kinetic analysis reveals reversible, competitive and slow-binding inhibition of dipeptidyl peptidase-4 by trelagliptin (t1/2 for dissociation ≈ 30 minutes). X-ray diffraction data indicates a non-covalent interaction between dipeptidyl peptidase and trelagliptin.

Especificações

Sinónimos

AC-28020 | SYR 472 | D10179 | Q27258374 | SYR 111472 succinate | TRELAGLIPTIN SUCCINATE [JAN] | 1029877-94-8 | F20669 | SCHEMBL878010 | AS-10248 | Trelagliptin (succinate) | TRELAGLIPTIN SUCCINATE [WHO-DD] | WLN: Q1YQ1OR DG | SYR-472 succinate | Butanedio

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Trelagliptin succinate (SYR472) is a dipeptidyl peptidase IV (DPP-4) inhibitor which is used as a new long-acting drug for once-weekly treatment of type 2 diabetes mellitus (DM).

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Mecanismo de ação

Dipeptidyl peptidase IV inhibitor

Propriedades do produto

ALogP

-1.362

Contagem HBD

1

Ligação rotativa

6

Nomes e identificadores

Pubchem Sid

528773313

Sorrisos canónicos

CN1C(=O)C=C(N(C1=O)CC2=C(C=CC(=C2)F)C#N)N3CCCC(C3)N.C(CC(=O)O)C(=O)O

IUPAC Name

2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile;butanedioic acid

InChIKey

OGCNTTUPLQTBJI-XFULWGLBSA-N

INCHI

1S/C18H20FN5O2.C4H6O4/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20;5-3(6)1-2-4(7)8/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3;1-2H2,(H,5,6)(H,7,8)/t15-;/m1./s1

SMILES isoméricas

CN1C(=O)C=C(N(C1=O)CC2=C(C=CC(=C2)F)C#N)N3CCC[C@H](C3)N.C(CC(=O)O)C(=O)O

PubChem CID

44183569

Peso molecular

475.47

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Benzonitriles

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Benzonitriles
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzonitriles
• Alternative Parents: Dialkylarylamines Pyrimidones Aminopiperidines Aminopyrimidines and derivatives Fluorobenzenes Aryl fluorides Hydropyrimidines Dicarboxylic acids and derivatives Fatty acids and conjugates Vinylogous amides Heteroaromatic compounds Ureas Lactams Nitriles Azacyclic compounds Carboxylic acids Carbonyl compounds Organic oxides Organofluorides Monoalkylamines Hydrocarbon derivatives
• Molecular Framework: Not available
• Substituents: Dialkylarylamine - Benzonitrile - Fluorobenzene - Pyrimidone - Halobenzene - Aminopyrimidine - 3-aminopiperidine - Aryl fluoride - Aryl halide - Hydropyrimidine - Dicarboxylic acid or derivatives - Fatty acid - Pyrimidine - Piperidine - Heteroaromatic compound - Vinylogous amide - Lactam - Urea - Carboxylic acid derivative - Carboxylic acid - Azacycle - Organoheterocyclic compound - Carbonitrile - Nitrile - Organooxygen compound - Primary amine - Organic oxygen compound - Organic nitrogen compound - Amine - Carbonyl group - Hydrocarbon derivative - Organonitrogen compound - Primary aliphatic amine - Cyanide - Organic oxide - Organohalogen compound - Organofluoride - Aromatic heteromonocyclic compound
• Descrição: This compound belongs to the class of organic compounds known as benzonitriles. These are organic compounds containing a benzene bearing a nitrile substituent.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propriedades químicas e físicas

• DMSO (mg/mL) Solubilidade máxima: 95
• DMSO (mM) Solubilidade máxima: 199.8023009
• Água (mg/mL) Solubilidade máxima: 95
• Água (mM) Solubilidade máxima: 199.8023009
• Peso molecular: 475.500 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 6
• Exact Mass: 475.187 Da
• Monoisotopic Mass: 475.187 Da
• Topological Polar Surface Area: 168.000 Ų
• Heavy Atom Count: 34
• Formal Charge: 0
• Complexity: 750.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3