Tribendimidine - ≥98% , CAS No.115103-15-6

CAS: 115103-15-6 Cat. No.: T651747 Fórmula: C₂₈H₃₂N₆ Peso molecular: 452.59 PubChem CID: 3086564

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Tribendimidine is an orally active, broad-spectrum anthelmintic agent, with particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotinic acetylcholine receptor (nAChR) agonist .

In Vitro

Tribendimidine (100 μg/mL; 24 h) shows intoxication of C. elegans. Tribendimidine (0-100 μg/mL; 6 days) shows toxicity with an LC 50 value (concentration at which half the animals are dead) of 54.4 μg/mL. Tribendimidine (0-200 μg/mL; 64 h)-induced sterility is resisted by trb mutant hermaphrodites, and Levamisole-resistant mutants are resistant to Tribendimidine.. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tribendimidine (75 and 150 mg/kg; p.o.; once) shows inhibition activity against C. sinensis in rats, and shows inhibition against O. viverrini at 400 mg/kg in hamsters. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C. sinensis infected Female Wistar ratsDosage: 75 mg/kg and 150 mg/kg Administration: Oral administration, once Result: A 99.1% worm burden reduction was achieved at 150 mg/kg, and the worm burden reduction was still significant (68.9%) at 75 mg/kg.

Form:Solid

Specifications

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

Tribendimidine is an orally active, broad-spectrum anthelmintic agent, with particularly high activity against A. lumbricoides and N. americanus . Tribendimidine is also an L-type nicotinic acetylcholine receptor (nAChR) agonist.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%

Nomes e identificadores

• Sorrisos canónicos: CC(=NC1=CC=C(C=C1)N=CC2=CC=C(C=C2)C=NC3=CC=C(C=C3)N=C(C)N(C)C)N(C)C
• SMILES isoméricas: CC(=NC1=CC=C(C=C1)N=CC2=CC=C(C=C2)C=NC3=CC=C(C=C3)N=C(C)N(C)C)N(C)C
• PubChem CID: 3086564
• Peso molecular: 452.59

Alvos associados (não humanos)

Fasciola hepatica (191 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: DMSO : 50 mg/mL (110.48 mM; ultrasonic and adjust pH to 3 with HCl)
• Peso molecular: 452.600 g/mol
• XLogP3: 3.800
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 452.269 Da
• Monoisotopic Mass: 452.269 Da
• Topological Polar Surface Area: 55.900 Ų
• Heavy Atom Count: 34
• Formal Charge: 0
• Complexity: 651.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 115103-15-6, the molecular formula is C28H32N6, and the molecular weight is 452.59 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.