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Enzima metabólica/protease
Síntase de ácidos gordos (FASN)
TVB-2640 - 10mM in DMSO , CAS No.1399177-37-7

TVB-2640 - 10mM in DMSO , CAS No.1399177-37-7

Name: TVB-2640 - 10mM in DMSO , CAS No.1399177-37-7
SKU: T421492
Availability: InStock

CAS: 1399177-37-7 Cat. No.: T421492 Fórmula: C₂₇H₂₉N₅O Peso molecular: 439.55 PubChem CID: 66548316

COA

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TVB-2640 - 10mM in DMSO CAS No(1399177-37-7) by Aladdin Scientific

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Disponível para encomenda

GRADE & PURITY 10mM in DMSO

Synonyms

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral Specifications Propriedades do produto Nomes e identificadores Documentation Advanced Data Taxonomic Classification Estrutura 3D Alvos associados (humanos) Mecanismos de ação Certificados（CoA,COO,BSE/TSE e Mapa de Análise) Propriedades químicas e físicas FAQs e artigos Calculadoras de soluções Revisões

🧪

Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Visão geral

Information

TVB-2640 TVB-2640 (ASC-40, FASN-IN-2) is an orally bioavailable, pharmacological fatty acid synthase (FAS/FASN) inhibitor with therapeutic potential in patients with NAFLD and nonalcoholic steatohepatitis.

Targets

FAS

Specifications

Sinónimos

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

TVB-2640 (ASC-40, FASN-IN-2) is an orally bioavailable, pharmacological fatty acid synthase (FAS/FASN) inhibitor with therapeutic potential in patients with NAFLD and nonalcoholic steatohepatitis.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Propriedades do produto

ALogP

4.638

Contagem HBD

Ligação rotativa

Nomes e identificadores

Pubchem Sid

528767450

Sorrisos canónicos

CC1=CC(=C(C=C1C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C4=NNC(=N4)C)C5CCC5

IUPAC Name

4-[1-[4-cyclobutyl-2-methyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)benzoyl]piperidin-4-yl]benzonitrile

InChIKey

BBGOSBDSLYHMRA-UHFFFAOYSA-N

INCHI

1S/C27H29N5O/c1-17-14-24(22-4-3-5-22)25(26-29-18(2)30-31-26)15-23(17)27(33)32-12-10-21(11-13-32)20-8-6-19(16-28)7-9-20/h6-9,14-15,21-22H,3-5,10-13H2,1-2H3,(H,29,30,31)

SMILES isoméricas

CC1=CC(=C(C=C1C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C4=NNC(=N4)C)C5CCC5

PubChem CID

66548316

Peso molecular

439.55

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Classe Benzene and substituted derivatives
    - Subclass Benzoyl derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Classe	Benzene and substituted derivatives
Subclass	Benzoyl derivatives
Intermediate Tree Nodes	Not available
Direct Parent	1-benzoylpiperidines
Alternative Parents	N-benzoylpiperidines Phenylpiperidines Phenyl-1,2,4-triazoles o-Toluamides Benzamides Benzonitriles Tertiary carboxylic acid amides Heteroaromatic compounds Tertiary amines Amino acids and derivatives Nitriles Azacyclic compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	1-benzoylpiperidine - N-benzoylpiperidine - Phenylpiperidine - Phenyltriazole - Phenyl-1,2,4-triazole - Benzamide - Benzoic acid or derivatives - O-toluamide - N-acyl-piperidine - Toluamide - Benzonitrile - Toluene - Piperidine - Tertiary carboxylic acid amide - Azole - Heteroaromatic compound - Triazole - 1,2,4-triazole - Amino acid or derivatives - Carboxamide group - Tertiary amine - Nitrile - Carbonitrile - Azacycle - Carboxylic acid derivative - Organoheterocyclic compound - Organonitrogen compound - Hydrocarbon derivative - Amine - Organic oxide - Cyanide - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Aromatic heteromonocyclic compound
Descrição	This compound belongs to the class of organic compounds known as 1-benzoylpiperidines. These are compounds containing a piperidine ring substituted at the 1-position with a benzoyl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estrutura 3D

Alvos associados (humanos)

FASN Tchem Fatty acid synthase (2 Activities)

Discover Target: FASN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mecanismos de ação

Certificados（CoA,COO,BSE/TSE e Mapa de Análise)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Propriedades químicas e físicas

DMSO (mg/mL) Solubilidade máxima	88
DMSO (mM) Solubilidade máxima	200.204754862928
Água (mg/mL) Solubilidade máxima	＜1
Peso molecular	439.600 g/mol
XLogP3	5.300
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	439.237 Da
Monoisotopic Mass	439.237 Da
Topological Polar Surface Area	85.700 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	728.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

FAQs e artigos

Why Do Cancer Cells Synthesize Their Own Fatty Acids? From the De Novo Fatty Acid Synthesis Pathway to Experimental Assessment

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Cancer Cells Synthetic fatty acids

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Revisões

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