Tyrphostin 9 - 10mM in DMSO , CAS No.10537-47-0

CAS: 10537-47-0 Cat. No.: T408102 Fórmula: C₁₈H₂₂N₂O Peso molecular: 282.38 Número CE: 634-647-0 PubChem CID: 5614

GRAU & PUREZA 10mM in DMSO

Synonyms

SF 6847, RG-50872 | Propanedinitrile, 2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Tyrphostin 9 (SF 6847, RG-50872) is firstly designed as anEGFRinhibitor withIC50of 460 μM, but is also found to be more potent toPDGFRwithIC50of 0.5 μM.
In vitro

SF 6847 inhibits the replication of herpes simplex virus type 1 (HSV-1) with IC50 of 40 nM. SF 6847 (50 nM) partly reverses sodium orthovanadate induced HSV-1 plaque formation. SF 6847 (< 400 nM) decreases the phosphorylation of viral phosphoproteins in a dose-dependent manner, but the SF 6847 (< 800 nM)-induced reduction of protein synthesis is not dose-dependent. SF 6847 prevents PDGF-induced tyrosine phosphorylation of LRP in caveolae in human fibroblasts suggesting that PDGF-BB-mediated LRP activation requires tyrosine phosphorylation and therefore activation of PDGFR-β. SF 6847 (1 mM) blocks the strain-induced stimulatory effect on DNA synthesis of fetal lung cells. SF 6847 (1 μM) causes increased exon inclusion of MAPT exon 10. SF 6847 does not affect the translation or stability of the two mRNAs. SF 6847 (1.6 μM) increases the inclusion of MAPT exon 10 by 2-fold in SHSY-5Y cells.

In vivo

Cell Data

cell lines：A431, BGC-823, A549, H460, HCT8, KB and Bel-7402 cells.

Concentrations：

Incubation Time：

Powder Purity:≥99%

Especificações

Sinónimos

SF 6847, RG-50872 | Propanedinitrile, 2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Tyrphostin 9 (SF 6847, RG-50872) is firstly designed as an EGFR inhibitor with IC50 of 460 μM, but is also found to be more potent to PDGFR with IC50 of 0.5 μM.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Nomes e identificadores

SMILES isoméricas

CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N

WGK Alemanha

3

RTECS

OO3737000

PubChem CID

5614

Peso molecular

282.38

Alvos associados (humanos)

CYP2C9 Tchem Cytochrome P450 2C9 (1 Activities)

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 51 mg/mL (197.46 mM)
• Índice de refração: 1.56
• Ponto de ebulição (°C): ~386.8° C at 760 mmHg
• Ponto de fusão (°C): 139-140°C