UBA5-IN-1 - ≥98% , CAS No.1831169-11-9

CAS: 1831169-11-9 Cat. No.: U649645 Fórmula: C₂₆H₄₀F₆N₁₀O₁₁S₂Zn Peso molecular: 912.16

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

UBA5-IN-1 (compound 8.5) is a selective UBA5 inhibitor with an IC 50 value of 4.0 μM. UBA5-IN-1 inhibits cell proliferation of Sk-Luci6 cancer cells with high expression levels of UBA5

In Vitro

UBA5-IN-1 (0.1-1000 μM) shows dose-dependent inhibition effect to UBA5 with an IC 50 value of 4.0 μM, and inhibits UAE and NAE with IC 50 values of 78.5 and 66.8 μM, respectively. UBA5-IN-1 (0-5 μM) inhibits UBA5 non-competitively with respect to ATP. UBA5-IN-1 (10 μM) shows no effect on ATP binding to human kinase. UBA5-IN-1 (0-50 μM; 72 h) effects cell proliferation of Sk-Luci6 cancer cells with high expression levels of UBA5. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: Sk-Luci6 cancer cells with high expression levels of UBA5 Concentration: 0-50 μM Incubation Time: 0-72 h Result: Showed selective anti-proliferative activity for Sk-Luci6 cancer cells which expressed higher UBA5 protein levels, but showed no anti-proliferative activity to MRC9 lung fibroblasts and A549 carcinoma cells.

Form:Solid

IC50& Target:IC50: 4.0 μM (UBA5), 78.5 μM (UAE), 66.8 μM (NAE)

Specifications

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

UBA5-IN-1 (compound 8.5) is a selective UBA5 inhibitor with an IC 50 value of 4.0 μM. UBA5-IN-1 inhibits cell proliferation of Sk-Luci6 cancer cells with high expression levels of UBA5.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%

Nomes e identificadores

• Sorrisos canónicos: O=S(C(F)(F)F)([O-])=O.O=S(C(F)(F)F)([O-])=O.NC1=C(N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](C(NCCCCCC([N]45[Zn+2]67[N@@](CC[N]6([H])CC[N@]7([H])CC5)([H])CC4)=O)=O)O3)C2=NC=N1
• Peso molecular: 912.16

Propriedades químicas e físicas

• Solubilidade: DMF : 100 mg/mL (109.63 mM; Need ultrasonic) DMSO : 50 mg/mL (54.81 mM; ultrasonic and warming and heat to 60°C)

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1831169-11-9, the molecular formula is C26H40F6N10O11S2Zn, and the molecular weight is 912.16 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.