Valiltramiprosate - 10mM in Water , Beta amyloid A4 protein stabiliser, CAS No.1034190-08-3, Beta amyloid A4 protein stabiliser

CAS: 1034190-08-3 Cat. No.: V655398 Fórmula: C₈H₁₈N₂O₄S Peso molecular: 238.30 PubChem CID: 25008296

GRADE & PURITY 10mM in Water

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease .

In Vivo

ALZ-801 (oral administration; 172?mg/kg; single dose) exhibits mean AUCt values of 58,758 and? 5841 ng/ml.h in plasma and brain, respectively. The ALZ-801: Tramiprosate ratio in plasma and brain is 1.8 and 3.1, respectively in male CD-1 mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:β-amyloid

Specifications

Especificações e pureza

10mM in Water

Mecanismos bioquímicos e fisiológicos

ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent

Condições de armazenamento de armazenamento

Desiccated,Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

STABILISER

Mecanismo de ação

Beta amyloid A4 protein stabiliser

Propriedades do produto

• ALogP: -3

Nomes e identificadores

• SMILES isoméricas: CC(C)[C@@H](C(=O)NCCCS(=O)(=O)O)N
• PubChem CID: 25008296
• Peso molecular: 238.30