VU6019650 - ≥98% , CAS No.V659239

CAS: V659239 Cat. No.: V659239 Fórmula: C₁₈H₂₂FN₃O₃S₂ Peso molecular: 411.51

GRAU & PUREZA ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

VU6019650 is a potent and selective orthosteric antagonist of M5 mAChR ( IC 50 =36 nM), can be used for opioid use disorder (OUD) relief. VU6019650 can cross blood brain barrier, potentially modulates the mesolimbic dopaminergic reward circuitry. VU601965

Appearance:Solid

IC50& Target:mAChR5|36 nM (IC|50|)

In Vitro:VU6019650 (0-10 μM) shows high selectivity for M5 (IC 50 =36 nM) over other subtypes (>100-fold selectivity against human M 1-4 ). VU6019650 (1 μM) blocks Oxo-M-induced activation of VTA neurons. VU6019650 exhibits brain penetrance with rat brai

In Vivo:VU6019650 (10-56.6mg/kg; i.p.; single dose) inhibits the rewarding effects of Oxycodone and reduces oxycodone self-administration in rats. Pharmacokinetic Analysis in ratsRoute Dose mg/kg) t (term) (min) MRT (min) Cl_obs (mL/min/kg) Vd ss (L/k

Biological Activity:VU6019650 is a potent and selective orthosteric antagonist of M5 mAChR ( IC 50 =36 nM), can be used for opioid use disorder (OUD) relief. VU6019650 can cross blood brain barrier, potentially modulates the mesolimbic dopaminergic reward circuitry. VU601965

Especificações

Especificações e pureza

≥98%

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%

Nomes e identificadores

Sorrisos canónicos

O=S(C1=CC2=C(OCC2)C=C1)(N(CC[C@@H]3CSC4=NC=CN4C)C[C@@H]3F)=O

Peso molecular

411.51

Perguntas frequentes

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is V659239, the molecular formula is C18H22FN3O3S2, and the molecular weight is 411.51 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.