XL01126 - ≥99% , CAS No.X658669

CAS: X658669 Cat. No.: X658669 Fórmula: C₅₀H₆₄ClFN₁₀O₆S₂ Peso molecular: 1019.69

GRAU & PUREZA ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Application

PROTAC

Visão geral

XL01126 is a potent degrader of LRRK2 with DC 50 s of 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2), respectively. XL01126 can cross blood-brain barrier and be used as a degrader probe in Parkinson’s disease research. XL01126 exerts function of study of non-c

Appearance:Solid

IC50& Target:DC50: 15-72 nM (LRRK2)

In Vitro:XL01126 (300 nM; 4 h) exhibits strong degradation performance by forming a positively cooperative ternary complex with E3 ubiquitin ligase ligand VHL and target protein LRRK2. XL01126 (10, 30, 100 nM; 24 h) increases mitophagy in immortalized mouse e

In Vivo:XL01126 (30mg/kg; p.o.; single dose) shows oral activity with bioavailable value (F) of 15% and can penetrate the blood brain barrier after either oral or parenteral dosing in mice. Pharmacokinetic property of XL01126 in miceRoute Dose mg/kg)

Biological Activity:XL01126 is a potent degrader of LRRK2 with DC 50 s of 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2), respectively. XL01126 can cross blood-brain barrier and be used as a degrader probe in Parkinson’s disease research . XL01126 exerts function of study of non-

Especificações

Especificações e pureza

≥99%

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥99%

Nomes e identificadores

Peso molecular

1019.69

Propriedades químicas e físicas

• Solubilidade: DMSO : ≥ 100 mg/mL (98.07 mM)