YK11 - ≥98% , CAS No.1370003-76-1

CAS: 1370003-76-1 Cat. No.: Y651509 Fórmula: C₂₅H₃₄O₆ Peso molecular: 430.53 PubChem CID: 119058028

GRADE & PURITY ≥98%

Synonyms

YK11 | YK-11 | DTXSID301107018 | 19-Norpregna-4,20-diene-21-carboxylic acid, 17,20-((1-methoxyethylidene)bis(oxy))-3-oxo-, methyl ester, (17alpha,20E)- | Q27295178 | Z9748J6B0R | 1370003-76-1 | UNII-Z9748J6B0R | YK11 cpd | (17alpha,20E)-17,20-((1-Methoxye

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

YK11 is a partial agonist of androgen receptor , with osteogenic activity.

In Vitro

YK11 is a partial agonist of androgen receptor, and induces myogenic differentiation of C2C12 Cells at 500 nM via Fst mRNA upregulation by AR. YK11 enhances Myf5 and myogenin mRNA expression, but requires high concentrations (YK11, 100?nM or 500?nM). YK11 (0.5?μM) increases the cell growth of osteoblastic MC3T3-E1 cells, and enhances ALP activity via AR. YK11 also elevates osteoprotegerin mRNA expression (0.5?μM) and dose-dependently increases osteocalcin mRNA expression (0.1-1.0 μM). In addition, YK11 enhances phosphorylation of Akt protein via rapid non-genomic signaling. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Androgen receptor

Specifications

Sinónimos

YK11 | YK-11 | DTXSID301107018 | 19-Norpregna-4,20-diene-21-carboxylic acid, 17,20-((1-methoxyethylidene)bis(oxy))-3-oxo-, methyl ester, (17alpha,20E)- | Q27295178 | Z9748J6B0R | 1370003-76-1 | UNII-Z9748J6B0R | YK11 cpd | (17alpha,20E)-17,20-((1-Methoxye

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

YK11 is a partial agonist of androgen receptor , with osteogenic activity.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%

Nomes e identificadores

Sorrisos canónicos

CC12CCC3C(C1CCC24C(=CC(=O)OC)OC(O4)(C)OC)CCC5=CC(=O)CCC35

IUPAC Name

methyl (2E)-2-[(8R,9S,10R,13S,14S,17S)-2'-methoxy-2',13-dimethyl-3-oxospiro[1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,5'-1,3-dioxolane]-4'-ylidene]acetate

InChIKey

KCQHQCDHFVGNMK-PQUNLUOYSA-N

INCHI

1S/C25H34O6/c1-23-11-9-18-17-8-6-16(26)13-15(17)5-7-19(18)20(23)10-12-25(23)21(14-22(27)28-3)30-24(2,29-4)31-25/h13-14,17-20H,5-12H2,1-4H3/b21-14+/t17-,18+,19+,20-,23-,24?,25+/m0/s1

SMILES isoméricas

C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@]24/C(=C\C(=O)OC)/OC(O4)(C)OC)CCC5=CC(=O)CC[C@H]35

CAS alternativo

1370003-76-1

PubChem CID

119058028

Termos de entrada MeSH

17,20-((1-methoxyethylidene)bis(oxy))-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester;YK11 cpd

Peso molecular

430.53

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Classe Steroids and steroid derivatives
      • Subclass Oxosteroids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Classe: Steroids and steroid derivatives
• Subclass: Oxosteroids
• Intermediate Tree Nodes: Not available
• Direct Parent: Oxosteroids
• Alternative Parents: 3-oxo delta-4-steroids Delta-4-steroids Ortho esters Fatty acid esters Cyclohexenones Carboxylic acid orthoesters Vinylogous esters Methyl esters Enones Enoate esters Acryloyl compounds 1,3-dioxolanes Oxacyclic compounds Monocarboxylic acids and derivatives Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic heteropolycyclic compounds
• Substituents: Oxosteroid - 3-oxosteroid - 3-oxo-delta-4-steroid - Delta-4-steroid - Cyclohexenone - Ortho ester - Fatty acid ester - Carboxylic acid orthoester - Fatty acyl - Vinylogous ester - Alpha,beta-unsaturated ketone - Alpha,beta-unsaturated carboxylic ester - Enoate ester - Methyl ester - Enone - Acryloyl-group - Meta-dioxolane - Cyclic ketone - Ketone - Carboxylic acid ester - Oxacycle - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Aliphatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as oxosteroids. These are steroid derivatives carrying a C=O group attached to steroid skeleton.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propriedades químicas e físicas

• Solubilidade: DMSO : 66.67 mg/mL (154.86 mM; Need ultrasonic)