YS-370 - ≥98% , CAS No.2470908-79-1

CAS: 2470908-79-1 Cat. No.: Y646618 Fórmula: C₃₇H₃₅BrN₄O₃ Peso molecular: 663.60

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein ( P-gp ). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity.

Form:Solid

Specifications

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein ( P-gp ). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to pacl

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%

Nomes e identificadores

• Sorrisos canónicos: COC1=CC2=NC=NC(C3=C(C4=CC=CC=C4)N(CC5=CC=CC=C5Br)C6=C3C=CC=C6)=C2C=C1OCCCN7CCOCC7
• Peso molecular: 663.60

Propriedades químicas e físicas

• Solubilidade: DMSO : 8.33 mg/mL (12.55 mM; ultrasonic and warming and heat to 80°C)