1,10-Decanediol - Moligand™, ≥98% , CAS No.112-47-0

CAS: 112-47-0 Cat. No.: D107052 Peso molecular: 174.28 Beilstein Registry Number: 1698975 Número EC: 203-975-2

GRADE & PURITY Moligand™, ≥98%

Synonyms

Decamethylene glycol | 1,10-Dihydroxydecane

Storage

Room temperature

Shipped In

Normal

Descripción general

1,10-Decanediol is a diol compound that can react with α-ketoglutarate (aKG) to generate polymeric microparticles (termed paKG MPs) for the sustained release of aKG, thereby promoting immunosuppressive regulation. Additionally, paKG MPs can bind to dendritic cells (DCs), reducing their glycolysis and mitochondrial respiration in vitro. These metabolic changes lead to the modulation of MHC-II and CD86 expression in DCs and alter the frequency of regulatory T cells (Tregs) as well as T-helper type 1/2/17 cells in vitro. 1,10-Decanediol can be used in research within the field of immunometabolism.

Specifications

Sinónimos

Decamethylene glycol | 1, 10-Dihydroxydecane

Especificaciones y pureza

Moligand™, ≥98%

Condiciones de almacenamiento de almacenamiento

Room temperature

Enviado en

Normal

Grado

Moligand™

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 488183286
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488183286
• Sonrisas canónicas: C(CCCCCO)CCCCO
• IUPAC Name: decane-1,10-diol
• InChIKey: FOTKYAAJKYLFFN-UHFFFAOYSA-N
• INCHI: 1S/C10H22O2/c11-9-7-5-3-1-2-4-6-8-10-12/h11-12H,1-10H2
• Isómeros SMILES: C(CCCCCO)CCCCO
• WGK Alemania: 1
• RTECS: HD8433713
• Peso molecular: 174.28
• Beilstein: 1698975
• Reaxy-Rn: 1698975
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1698975&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Clase Fatty Acyls
      • Subclass Fatty alcohols

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Clase: Fatty Acyls
• Subclass: Fatty alcohols
• Intermediate Tree Nodes: Not available
• Direct Parent: Fatty alcohols
• Alternative Parents: Primary alcohols Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Fatty alcohol - Organic oxygen compound - Hydrocarbon derivative - Primary alcohol - Organooxygen compound - Alcohol - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as fatty alcohols. These are aliphatic alcohols consisting of a chain of a least six carbon atoms.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Soluble in alcohol. Insoluble in water, petroleum ether.
• Punto de inflamación (°F): 305.6 °F
• Punto de inflamación (°C): 152℃
• Punto de ebullición (°C): 297°C
• Punto de fusión (°C): 71-75°C
• Peso molecular: 174.280 g/mol
• XLogP3: 2.500
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 9
• Exact Mass: 174.162 Da
• Monoisotopic Mass: 174.162 Da
• Topological Polar Surface Area: 40.500 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 64.200
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Min Wu, Yitao Zhao, Meihan Tao, Meimei Fu, Yue Wang, Qi Liu, Zhihui Lu, Jinshan Guo.  (2023)  Malate-Based Biodegradable Scaffolds Activate Cellular Energetic Metabolism for Accelerated Wound Healing.  ACS Applied Materials & Interfaces,      [PMID:37903387] [10.1021/acsami.3c09394]

2. Jun-Tao Shi, Xian-Hui Chen, Yuan-Yuan Peng, Gui-Ping Wang, Guang-Yan Du, Quan Li.  (2023)  Tunable Fluorescence and Morphology of Aggregates Built from a Mechanically Bonded Amphiphilic Bistable [2]Rotaxane.  CHEMISTRY-A EUROPEAN JOURNAL,  29  (59): (e202302132).  [PMID:37526053] [10.1002/chem.202302132]

3. Yingchia Hung, Wangkai Xiang, Zongjun Zou, Yuanhua Zhang, Bao Wang, Chengtao Yu, Ying Zheng, Pengju Pan.  (2023)  Isodimorphic crystallization and thermally-induced crystal transitions in poly(octamethylene-ran-decamethylene carbonate): Critical role of comonomer defects.  POLYMER,      [PMID:] [10.1016/j.polymer.2023.125903]

4. Jing Yu, Yan Kang, Hongyang Zhang, Feng Yang, Huajun Zhen, Xixi Zhu, Ting Wu, Yiping Du.  (2021)  A Polymer-Based Matrix for Effective SALDI Analysis of Lipids.  JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,      [PMID:33904725] [10.1021/jasms.1c00010]

5. Gao Hongwei, Liu Huihui, He Jinmei, Bai Yongping.  (2020)  Synthesis and properties of poly(ethylene terephthalate) modified with a small amount of 1,10-decanediamine and hydrogen bonds.  JOURNAL OF MATERIALS SCIENCE,  56  (7): (4922-4939).  [PMID:] [10.1007/s10853-020-05590-7]

6. Zhencai Zhang, Fei Xu, Hongyan He, Weilu Ding, Wenjuan Fang, Wei Sun, Zengxi Li, Suojiang Zhang.  (2019)  Synthesis of high-molecular weight isosorbide-based polycarbonates through efficient activation of endo-hydroxyl groups by an ionic liquid.  GREEN CHEMISTRY,  21  (14): (3891-3901).  [PMID:] [10.1039/C9GC01500K]

7. Siyuan Xu, Feng Wu, Zhikai Li, Xiang Zhu, Xiaohong Li, Lian Wang, Yongjin Li, Yingfeng Tu.  (2019)  A green cascade polymerization method for the facile synthesis of sustainable poly(butylene-co-decylene terephthalate) copolymers.  POLYMER,      [PMID:] [10.1016/j.polymer.2019.121591]

8. Hui Li, Lin Gu.  (2018)  Controllable synthesis of bio-based polylactide diols using an organocatalyst in solvent-free conditions.  JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,  56  (9): (968-976).  [PMID:] [10.1002/pola.28974]

9. Zhu Lixia, Dai Jinyue, Chen Lai, Chen Jing, Na Haining, Zhu Jin.  (2016)  Design and fabrication of imidazolium ion-immobilized electrospun polyurethane membranes with antibacterial activity.  JOURNAL OF MATERIALS SCIENCE,  52  (5): (2473-2483).  [PMID:] [10.1007/s10853-016-0542-z]

10. Keling Hu, Dongping Zhao, Guolin Wu, Jianbiao Ma.  (2016)  Bio-based aromatic copoly(ether ester)s with enhanced toughness and degradability: Influence of insertion of phenoxy-ether linkage and eugenol-derived composition on properties.  JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,  54  (14): (2171-2183).  [PMID:] [10.1002/pola.28089]

11. Keling Hu, Dongping Zhao, Guolin Wu, Jianbiao Ma.  (2015)  Synthesis and properties of polyesters derived from renewable eugenol and α,ω-diols via a continuous overheating method.  Polymer Chemistry,  6  (40): (7138-7148).  [PMID:] [10.1039/C5PY01075F]

12. Wenwen Xue, Lisheng Zhang, Haizhen Chen, Jinggang Wang, Haining Na, Jin Zhu.  (2015)  Synthesis of polyurethane containing carbon–carbon double bonds to prepare functionalizable ultrafine fibers via electrospinning.  Polymer Chemistry,  6  (20): (3858-3864).  [PMID:] [10.1039/C5PY00107B]

13. Lisheng Zhang, Miaoming Huang, Ruilei Yu, Juncheng Huang, Xia Dong, Ruoyu Zhang, Jin Zhu.  (2014)  Bio-based shape memory polyurethanes (Bio-SMPUs) with short side chains in the soft segment.  Journal of Materials Chemistry A,  2  (29): (11490-11498).  [PMID:] [10.1039/C4TA01640H]

14. Jian Hu, Xueyan Yun, Yan Zheng, Tao Sun, Lijun Song, Pengju Pan, Tungalag Dong.  (2024)  Development of ultra-thin poly(L-lactic acid)-based films integrating toughness, barrier properties, and gas selectivity: Towards gas-permeation controllable green food packaging.  FOOD CHEMISTRY,      [PMID:38579656] [10.1016/j.foodchem.2024.139218]

15. Zhencai Zhang, Zifeng Yang, Ming Jiang, Wenjuan Fang, Heng Wang, Chenhao Li, Xin Yao, Zengxi Li, Fei Xu.  (2024)  Green and Efficient Synthesis of Biobased Polycarbonates with Tunable Performance via Functionalized Ionic Liquid Catalysts Enhanced by Cation–π Interactions.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.4c00480]

16. Wentao Zhang, Mi Feng, Shijie Wang, Ming Jiang, Zhichao Shang, Shaojuan Zeng, Xiangping Zhang, Fei Xu.  (2024)  High-Molecular-Weight Biobased Polycarbonate Preparation Using Metal-Free Deep Eutectic Solvents: Efficient Activation of the Hydroxyl Groups.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.4c02503]

17. He Shao, Yu Ji, Ruiheng Wang, Jing Liu, Yueqing Li, Benxin Liu, Wen Li, Yannan Xie, Linghai Xie, Johnny C. Ho, Wei Huang, Haifeng Ling.  (2024)  Optically enhanced organic phototransistors for adaptive image processing under complex light conditions.  Nano Energy,      [PMID:] [10.1016/j.nanoen.2024.110133]

18. Jinhong Hao, Hanbin Liu, Shiyu Du, Huacui Xiang, Guodong Liu, Zhijian Li, Hongwei Zhou.  (2024)  Rational design of biomass-derived and UV-curable dynamic polymer for the encapsulation of paper-based flexible strain sensor.  Materials Today Sustainability,      [PMID:] [10.1016/j.mtsust.2024.100756]

19. Shi-Si Li, Jun-Lin Pan, Xi-Long Chen, Jing Xu, Zi-Long Li, Chunzu Cheng.  (2024)  Synthesis of long-chain aliphatic poly(β-thioester)s via thiol-Michael polyaddition and their applications in noble metal recovery and information encryption.  EUROPEAN POLYMER JOURNAL,      [PMID:] [10.1016/j.eurpolymj.2024.113290]

20. Zhou Xiaorui, Yang Ying, Lv Chang, Cheng Xinru, Hao Wenbo, Su Tingting, Huang Chenhao, Hu Bing.  (2026)  Influence of Carbon Chain Length and Odd–Even Effect on the Properties of Azelaic Acid-Based Aliphatic Polyesters.  JOURNAL OF POLYMERS AND THE ENVIRONMENT,  34  (4): (80).  [PMID:] [10.1007/s10924-026-03770-1]

21. Shilong Zhong, Yongjian Zhu, Weien Liang, Yuntao Hu, Weibin Liu, Yiyong Chen, Chengbin Zou, Jinru Li, Xin Liu, Zhongke Yuan, Yujie Chen, Zhiguo Liu, Jingyi Rao, Zhaoxiang Zhu, Cheng Wang, Xudong Chen.  (2026)  Buckling-Induced Angular-Switchable Diffraction Images on Polyurethane Film for Optical Encryption and Anti-Counterfeiting.  ADVANCED MATERIALS,      [PMID:42464774] [10.1002/adma.74145]