1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) (DOTAP Chloride) - Moligand™, ≥98% , CAS No.132172-61-3

CAS: 132172-61-3 Cat. No.: D292990 Peso molecular: 698.54

GRADE & PURITY Moligand™, ≥98%

Synonyms

N-(2,3-Dioleoyloxy)propyl-N,N,N-trimethylammonium Chloride | Dotap chloride | N,N,N-Trimethyl-2,3-bis(oleoyloxy)propan-1-aminium chloride | N,N,N-Trimethyl-2,3-bis[(9Z)-9-octadecenoyloxy]-1-propanaminium Chloride

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Specifications

Sinónimos

N-(2, 3-Dioleoyloxy)propyl-N, N, N-trimethylammonium Chloride | Dotap chloride | N, N, N-Trimethyl-2, 3-bis(oleoyloxy)propan-1-aminium chloride | N, N, N-Trimethyl-2, 3-bis[(9Z)-9-octadecenoyloxy]-1-propanaminium Chloride

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

DOTAP chloride can be used to prepare liposomes without the use of auxiliary phospholipids. DOTAP chloride is soluble in dimethyl sulfoxide (DMSO) and ethanol, which can clarify its role as a transfection reagent.

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504766612
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504766612
• Sonrisas canónicas: CCCCCCCCC=CCCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC.[Cl-]
• IUPAC Name: 2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;chloride
• InChIKey: KSXTUUUQYQYKCR-LQDDAWAPSA-M
• INCHI: 1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,40H,6-19,24-39H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-
• Isómeros SMILES: CCCCCCCC/C=C\CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC.[Cl-]
• Peso molecular: 698.54
• Reaxy-Rn: 22197383
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22197383&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Clase Fatty Acyls
      • Subclass Fatty acid esters

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Clase: Fatty Acyls
• Subclass: Fatty acid esters
• Intermediate Tree Nodes: Not available
• Direct Parent: Fatty acid esters
• Alternative Parents: Dicarboxylic acids and derivatives Tetraalkylammonium salts Carboxylic acid esters Organic oxides Organic chloride salts Hydrocarbon derivatives Carbonyl compounds Amines Organic cations
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Fatty acid ester - Dicarboxylic acid or derivatives - Quaternary ammonium salt - Tetraalkylammonium salt - Carboxylic acid ester - Carboxylic acid derivative - Organic chloride salt - Organic salt - Organic oxide - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Amine - Hydrocarbon derivative - Organic cation - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as fatty acid esters. These are carboxylic ester derivatives of a fatty acid.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

Got2 Aspartate aminotransferase mitochondrial (49 Activities)

Discover Target: Got2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Sensibilidad: Light & Heat and moisture sensitive
• Peso molecular: 698.500 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 37
• Exact Mass: 697.578 Da
• Monoisotopic Mass: 697.578 Da
• Topological Polar Surface Area: 52.600 Ų
• Heavy Atom Count: 48
• Formal Charge: 0
• Complexity: 754.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 2

XLogP3

Referencias

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3. Zhiqiang Zhang, Qinglong Wang, Haibo Zhang, Shengchao Wang, Xia Ma, Hui Wang.  (2024)  Golm1 facilitates the CaO2-DOPC-DSPE200-PEI -CsPbBr3 QDs -induced apoptotic death of hepatocytes through the stimulation of mitochondrial autophagy and mitochondrial reactive oxygen species production through interactions with P53/Beclin-1/Bcl-2.  CHEMICO-BIOLOGICAL INTERACTIONS,      [PMID:38815669] [10.1016/j.cbi.2024.111076]

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5. Zenan Zhang, Zichao Liu, Lingling Lei, Xiaowen Liang, Zhili Guo, Shun Liu, Jie Lan, Meng Du, Zhiyi Chen.  (2026)  Dual-parameter sequential ultrasound irradiation with oxygen-loaded microbubbles induces vascular normalization to potentiate sonodynamic therapy in breast cancer.  Materials Today Bio,      [PMID:41584409] [10.1016/j.mtbio.2026.102777]

6. Xuhui Fan, Ruru Zhang, Linjun Yang, Shixiong Chen, Meijuan He, Yongqiang Wang, Linjie Huang, Jianfeng Zeng, Shuwang Wu, Mingyuan Gao, Han Wang.  (2026)  CRISPR-Cas9-Loaded Theranostic Liposomes for Enhancing Radiosensitization of Prostate Cancer through POLD4 Gene Editing under Real-Time MRI Monitoring.  Advanced Science,      [PMID:41498761] [10.1002/advs.202519704]

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