1,2-Dioleoil-sn-glicero-3-fosfoetanolamina - ≥98% , CAS No.4004-05-1

CAS: 4004-05-1 Cat. No.: D155634 Peso molecular: 744.05

GRADE & PURITY ≥98%

Synonyms

GPEtn(18:1w9/18:1w9) | 1,2-Dioleoyl-sn-gl | AMY10805 | DOPE, l- | SCHEMBL25038 | Ethanol, 2-amino-, dihydrogen phosphate (ester), monoester with 1,2-diolein, L- | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine | AS-74734 | PE(18:1/18:1) | 1,2-dioleoyl-sn-g

Storage

Almacenar a -20°C,cargado con argón

Shipped In

Hielera + almohadillas de hielo

Descripción general

Aplicación

Se ha observado que la DOPE en membranas mixtas disminuye el tiempo de vida de la fluorescencia y aumenta el orden de las cadenas de acilo. La DOPE es un componente esencial de los liposomas catiónicos diseñados para administrar ADN en líneas celulares de gliosarcoma y riñón (terapia génica).

Specifications

Sinónimos

GPEtn(18:1w9/18:1w9) | 1, 2-Dioleoyl-sn-gl | AMY10805 | DOPE, l- | SCHEMBL25038 | Ethanol, 2-amino-, dihydrogen phosphate (ester), monoester with 1, 2-diolein, L- | 1, 2-Dioleoyl-sn-glycero-3-phosphoethanolamine | AS-74734 | PE(18:1/18:1) | 1, 2-dioleoyl-sn-g

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

Se ha descubierto que la presencia de DOPE en la película mixta reduce el tiempo de vida de la fluorescencia y aumenta la secuencia de la cadena acilo. La DOPE es un componente importante de los liposomas catiónicos, diseñados específicamente para adminis

Condiciones de almacenamiento de almacenamiento

Almacenar a -20°C, cargado con argón

Enviado en

Hielera + almohadillas de hielo

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504764803
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504764803
• Sonrisas canónicas: CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)OCCN)OC(=O)CCCCCCCC=CCCCCCCCC
• IUPAC Name: [(2R)-3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate
• InChIKey: MWRBNPKJOOWZPW-NYVOMTAGSA-N
• INCHI: 1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1
• Isómeros SMILES: CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN)OC(=O)CCCCCCC/C=C\CCCCCCCC
• Peso molecular: 744.05
• Reaxy-Rn: 2343401
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2343401&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Clase Glycerophospholipids
      • Subclass Glycerophosphoethanolamines

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Clase: Glycerophospholipids
• Subclass: Glycerophosphoethanolamines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phosphatidylethanolamines
• Alternative Parents: Phosphoethanolamines Fatty acid esters Dialkyl phosphates Dicarboxylic acids and derivatives Carboxylic acid esters Amino acids and derivatives Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Diacylglycero-3-phosphoethanolamine - Phosphoethanolamine - Fatty acid ester - Dialkyl phosphate - Dicarboxylic acid or derivatives - Organic phosphoric acid derivative - Phosphoric acid ester - Alkyl phosphate - Fatty acyl - Amino acid or derivatives - Carboxylic acid ester - Carboxylic acid derivative - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Amine - Primary aliphatic amine - Organic nitrogen compound - Primary amine - Carbonyl group - Organic oxide - Hydrocarbon derivative - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as phosphatidylethanolamines. These are glycerophosphoetahnolamines in which two fatty acids are bonded to the glycerol moiety through ester linkages.
• External Descriptors: Diacylglycerophosphoethanolamines

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Sensibilidad: light & air & heat & Moisture sensitive
• Rotación específica [α]: +5.0 to +7.0 deg(C=2, CHCl3)
• Punto de fusión (°C): 200°C(lit.)
• Peso molecular: 744.000 g/mol
• XLogP3: 10.600
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 41
• Exact Mass: 743.547 Da
• Monoisotopic Mass: 743.547 Da
• Topological Polar Surface Area: 134.000 Ų
• Heavy Atom Count: 51
• Formal Charge: 0
• Complexity: 897.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 1

Referencias

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