1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine （DOPE） - ≥99%, 10 mg phospholipid per ml CHCl3,TLC , CAS No.4004-05-1

CAS: 4004-05-1 Cat. No.: D432691 Peso molecular: 744.05

GRADE & PURITY ≥99%, 10 mg phospholipid per ml CHCl3,TLC

Synonyms

GPEtn(18:1w9/18:1w9) | 1,2-Dioleoyl-sn-gl | AMY10805 | DOPE, l- | SCHEMBL25038 | Ethanol, 2-amino-, dihydrogen phosphate (ester), monoester with 1,2-diolein, L- | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine | AS-74734 | PE(18:1/18:1) | 1,2-dioleoyl-sn-g

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Application

1,2-Dioleoyl- sn -glycero-3-phosphoethanolamine (DOPE) forms heterogenous liposomes with N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP), which are used as delivery vehicles for therapeutic agents .

Specifications

Sinónimos

GPEtn(18:1w9/18:1w9) | 1, 2-Dioleoyl-sn-gl | AMY10805 | DOPE, l- | SCHEMBL25038 | Ethanol, 2-amino-, dihydrogen phosphate (ester), monoester with 1, 2-diolein, L- | 1, 2-Dioleoyl-sn-glycero-3-phosphoethanolamine | AS-74734 | PE(18:1/18:1) | 1, 2-dioleoyl-sn-g

Especificaciones y pureza

≥99%, 10 mg phospholipid per ml CHCl3, TLC

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥99%

Nombres e identificadores

• Sonrisas canónicas: CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)OCCN)OC(=O)CCCCCCCC=CCCCCCCCC
• IUPAC Name: [(2R)-3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate
• InChIKey: MWRBNPKJOOWZPW-NYVOMTAGSA-N
• INCHI: 1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1
• Isómeros SMILES: CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN)OC(=O)CCCCCCC/C=C\CCCCCCCC
• Peso molecular: 744.05
• Reaxy-Rn: 2343401
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2343401&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Clase Glycerophospholipids
      • Subclass Glycerophosphoethanolamines

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Clase: Glycerophospholipids
• Subclass: Glycerophosphoethanolamines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phosphatidylethanolamines
• Alternative Parents: Phosphoethanolamines Fatty acid esters Dialkyl phosphates Dicarboxylic acids and derivatives Carboxylic acid esters Amino acids and derivatives Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Diacylglycero-3-phosphoethanolamine - Phosphoethanolamine - Fatty acid ester - Dialkyl phosphate - Dicarboxylic acid or derivatives - Organic phosphoric acid derivative - Phosphoric acid ester - Alkyl phosphate - Fatty acyl - Amino acid or derivatives - Carboxylic acid ester - Carboxylic acid derivative - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Amine - Primary aliphatic amine - Organic nitrogen compound - Primary amine - Carbonyl group - Organic oxide - Hydrocarbon derivative - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as phosphatidylethanolamines. These are glycerophosphoetahnolamines in which two fatty acids are bonded to the glycerol moiety through ester linkages.
• External Descriptors: Diacylglycerophosphoethanolamines

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Rotación específica [α]: +5.0 to +7.0 deg(C=2, CHCl3)
• Punto de fusión (°C): 200°C(lit.)
• Peso molecular: 744.000 g/mol
• XLogP3: 10.600
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 41
• Exact Mass: 743.547 Da
• Monoisotopic Mass: 743.547 Da
• Topological Polar Surface Area: 134.000 Ų
• Heavy Atom Count: 51
• Formal Charge: 0
• Complexity: 897.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 1

Referencias

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