10-DEBC hydrochloride - Moligand™, ≥99% , Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase, CAS No.201788-90-1, Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase

CAS: 201788-90-1 Cat. No.: D335507 Peso molecular: 381.34 PubChem CID: 16760284

GRADE & PURITY Moligand™, ≥99%

Synonyms

aktX | 10-[4'-(n,n-diethylamino)butyl]-2-chlorophenoxazine hydrochloride | 10-DEBCHYDROCHLORIDE | 10-DEBC HYDROCHLORIDE | Akt Inhibitor-X | Akt Inhibitor X | CCG 206734 | 10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl | 4-(2-chlorophenoxazin-10-yl

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Descripción general

Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kin

Specifications

Sinónimos

aktX | 10-[4'-(n, n-diethylamino)butyl]-2-chlorophenoxazine hydrochloride | 10-DEBCHYDROCHLORIDE | 10-DEBC HYDROCHLORIDE | Akt Inhibitor-X | Akt Inhibitor X | CCG 206734 | 10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl | 4-(2-chlorophenoxazin-10-yl

Especificaciones y pureza

Moligand™, ≥99%

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Desiccated

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase

Pureza

≥99%

Nombres e identificadores

• Sonrisas canónicas: CCN(CC)CCCCN1C2=CC=CC=C2OC3=C1C=C(C=C3)Cl.Cl
• IUPAC Name: 4-(2-chlorophenoxazin-10-yl)-N,N-diethylbutan-1-amine;hydrochloride
• InChIKey: SVKSJUIYYCQZEC-UHFFFAOYSA-N
• INCHI: 1S/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H
• Isómeros SMILES: CCN(CC)CCCCN1C2=CC=CC=C2OC3=C1C=C(C=C3)Cl.Cl
• PubChem CID: 16760284
• Peso molecular: 381.34

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Benzoxazines
      • Subclass Phenoxazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Benzoxazines
• Subclass: Phenoxazines
• Intermediate Tree Nodes: Not available
• Direct Parent: N-substituted phenoxazines
• Alternative Parents: Alkyldiarylamines Diarylethers Benzenoids Aryl chlorides Quaternary ammonium salts Trialkylamines Oxacyclic compounds Azacyclic compounds Organochlorides Organic chloride salts Hydrocarbon derivatives Organic cations
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: N-substituted phenoxazine - Alkyldiarylamine - Diaryl ether - Tertiary aliphatic/aromatic amine - Aryl chloride - Aryl halide - Benzenoid - Quaternary ammonium salt - Tertiary aliphatic amine - Tertiary amine - Oxacycle - Azacycle - Ether - Organic salt - Hydrocarbon derivative - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Organic nitrogen compound - Organic chloride salt - Amine - Organic cation - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as n-substituted phenoxazines. These are phenoxyazines where the nitrogen atom is linked to an atom other than the hydrogen atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

PIM1 Tchem Serine/threonine-protein kinase pim-1 (1 Activities)

Discover Target: PIM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Soluble in water (1 mg/ml), DMSO (100 mM), and methanol.
• Índice de refracción: n20D1.57 (Predicted)
• Peso molecular: 381.300 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 380.142 Da
• Monoisotopic Mass: 380.142 Da
• Topological Polar Surface Area: 15.700 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 377.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3