16α-Hydroxy Progesterone - ≥98% , CAS No.438-07-3

CAS: 438-07-3 Cat. No.: H336075 Peso molecular: 330.46 Número EC: 881-156-4

GRADE & PURITY ≥98%

Synonyms

16a-hydroxyprogesterone | Pregn-4-ene-3, 16.alpha.-hydroxy- | Pregn-4-ene-3,20-dione, 16.alpha.-hydroxy- | Pregn-4-ene-3, 16-hydroxy-, (16.alpha.)- | NSC 523249 | SMR000457347 | UNII-Y7JT9A46EO | 16alpha-hydroxyprogesterone1 | DTXSID001017030 | (8S,9S,10R

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

16α-Hydroxy Progesterone a hydroxylated metabolite of Progesterone that binds to human progesterone receptors hPR-A and hPR-B and act as an agonist for both receptors.

Application

16α-Hydroxyprrogesterone is a hydroxylated metabolite of Progesterone (P755900). 16α-Hydroxyprogesterone binds to human progesterone receptors hPR-A and hPR-B and act as an agonist for both receptors.

Specifications

Sinónimos

16a-hydroxyprogesterone | Pregn-4-ene-3, 16.alpha.-hydroxy- | Pregn-4-ene-3, 20-dione, 16.alpha.-hydroxy- | Pregn-4-ene-3, 16-hydroxy-, (16.alpha.)- | NSC 523249 | SMR000457347 | UNII-Y7JT9A46EO | 16alpha-hydroxyprogesterone1 | DTXSID001017030 | (8S, 9S, 10R

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504758065
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504758065
• Sonrisas canónicas: CC(=O)C1C(CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)O
• IUPAC Name: (8S,9S,10R,13S,14S,16R,17R)-17-acetyl-16-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• InChIKey: LOVNYFVWYTXDRE-RMWFXKKMSA-N
• INCHI: 1S/C21H30O3/c1-12(22)19-18(24)11-17-15-5-4-13-10-14(23)6-8-20(13,2)16(15)7-9-21(17,19)3/h10,15-19,24H,4-9,11H2,1-3H3/t15-,16+,17+,18-,19+,20+,21+/m1/s1
• Isómeros SMILES: CC(=O)[C@H]1[C@@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O
• Peso molecular: 330.46
• Reaxy-Rn: 2062092
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2062092&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Clase Steroids and steroid derivatives
      • Subclass Pregnane steroids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Clase: Steroids and steroid derivatives
• Subclass: Pregnane steroids
• Intermediate Tree Nodes: Not available
• Direct Parent: Gluco/mineralocorticoids, progestogins and derivatives
• Alternative Parents: 20-oxosteroids 3-oxo delta-4-steroids 16-alpha-hydroxysteroids Delta-4-steroids Cyclohexenones Secondary alcohols Cyclic alcohols and derivatives Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic homopolycyclic compounds
• Substituents: Progestogin-skeleton - 20-oxosteroid - 3-oxo-delta-4-steroid - 3-oxosteroid - 16-hydroxysteroid - 16-alpha-hydroxysteroid - Hydroxysteroid - Oxosteroid - Delta-4-steroid - Cyclohexenone - Cyclic alcohol - Ketone - Secondary alcohol - Cyclic ketone - Hydrocarbon derivative - Organic oxygen compound - Carbonyl group - Alcohol - Organic oxide - Organooxygen compound - Aliphatic homopolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.
• External Descriptors: C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
• Sensibilidad: Moisture sensitive
• Punto de fusión (°C): >212°C (dec.)
• Peso molecular: 330.500 g/mol
• XLogP3: 3.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 330.219 Da
• Monoisotopic Mass: 330.219 Da
• Topological Polar Surface Area: 54.400 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 621.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 7
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Ma Jinglin, Zhuang Yan, Guan Huiting, Zhang Zhenjun, Zhu Ning, Han Changze, Wang Yonggang, Chen Jixiang.  (2026)  Functional characterization of steroid hydroxylation by cytochrome P450 enzymes from Rhodococcus erythropolis KB1.  Microbial Cell Factories,      [PMID:41612368] [10.1186/s12934-026-02940-z]