2',3'-cGAMP Sodium Salt - Moligand™, ≥98% , Agonist of stimulator of interferon response cGAMP interactor 1, CAS No.2734858-36-5, Agonist of stimulator of interferon response cGAMP interactor 1

CAS: 2734858-36-5 Cat. No.: C413868 Peso molecular: 718.37

GRADE & PURITY Moligand™, ≥98%

Synonyms

2/'3/'-cGAMP | cyclic [G(2',5')pA(3',5')p] | UNII-552Y49K43E | J3.180.146J | 2',5'-3',5'-cGAMP | 2'-3'-cyclic GMP-AMP;2',3'-cGAMP | 2-Amino-9-((5R,7R,8R,12aR,14R,15R,15aS,16R)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxy-2,10-dioxidooctahydro-12H-5,

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Information

2',3'-cGAMP Sodium Salt 2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium) is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ) . 2',3'-cGAMP binds to STING with Kd of 3.79 nM.

Targets

STING (Cell-free assay) 3.79 nM(Kd)

In vitro

2\',3\'-cGAMP is an endogenous second messenger produced by mammalian cells. 2\',3\'-cGAMP is a high affinity ligand for STING. 2\',3\'-cGAMP is a potent inducer of type-I interferons. 2\',3\'-cGAMP binding induces conformational changes of STING.

Cell Research(from reference)

Cell lines：A549, BSC-40, BSR-T7, Vero cells 

Concentrations：25 μM, 20 μM, 2.5 μM 

Incubation Time：30 min 

Specifications

Sinónimos

2/'3/'-cGAMP | cyclic [G(2', 5')pA(3', 5')p] | UNII-552Y49K43E | J3.180.146J | 2', 5'-3', 5'-cGAMP | 2'-3'-cyclic GMP-AMP;2', 3'-cGAMP | 2-Amino-9-((5R, 7R, 8R, 12aR, 14R, 15R, 15aS, 16R)-14-(6-amino-9H-purin-9-yl)-2, 10, 15, 16-tetrahydroxy-2, 10-dioxidooctahydro-12H-5,

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

2', 3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium) is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ). 2', 3'-cGAMP binds to STING with Kd of 3.79 nM.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

AGONIST

Mecanismo de acción

Agonist of stimulator of interferon response cGAMP interactor 1

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504773384
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773384
• CAS alternativo: 1441190-66-4
• Peso molecular: 718.37

Objetivos asociados (humanos)

TMEM173 Tchem Stimulator of interferon genes protein (8 Activities)

Discover Target: TMEM173

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THP-1 (11052 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Monocyte (474 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ENPP1 Tchem Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (635 Activities)

Discover Target: ENPP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MC-38 (857 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Irf3 Interferon regulatory factor 3 (2 Activities)

Discover Target: Irf3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Sting1 Stimulator of interferon genes protein (255 Activities)

Discover Target: Sting1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nuclease P1 (7 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro Water: 50 mg/mL (69.6 mM); DMSO: 12.5 mg/mL (17.4 mM)
• Sensibilidad: Moisture sensitive.
• Peso molecular: 674.400 g/mol
• XLogP3: -5.900
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 19
• Rotatable Bond Count: 2
• Exact Mass: 674.1 Da
• Monoisotopic Mass: 674.1 Da
• Topological Polar Surface Area: 325.000 Ų
• Heavy Atom Count: 45
• Formal Charge: 0
• Complexity: 1300.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 8
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1