Determine the necessary mass, volume, or concentration for preparing a solution.
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10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 17 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
2,3-Dihydroxybenzoic acid was found to be orally effective iron-chelating drug in hypertransfused rat model. It is monocatechol siderophore produced by Brucella abortus.
2,3-Dihydroxybenzoic acid was used to study the complexes of manganese with aliphatic and aromatic polyhydroxy ligands in basic media by electrochemical, spectrophotometric and magnetic methods. It was used in isolation of new siderophore named vulnibactin from low iron cultures of Vibrio vulnificus, a human pathogen. It was used as cocrystal former to study the influence of position isomerism on the co-crystals formation and physicochemical properties of piracetam.
| Sonrisas canónicas | C1=CC(=C(C(=C1)O)O)C(=O)O |
|---|---|
| IUPAC Name | 2,3-dihydroxybenzoic acid |
| InChIKey | GLDQAMYCGOIJDV-UHFFFAOYSA-N |
| INCHI | 1S/C7H6O4/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,8-9H,(H,10,11) |
| Isómeros SMILES | C1=CC(=C(C(=C1)O)O)C(=O)O |
| WGK Alemania | 2 |
| RTECS | DG8576490 |
| Peso molecular | 154.12 |
| Beilstein | 2209120 |
| Reaxy-Rn | 2209117 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2209117&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Clase | Benzene and substituted derivatives |
| Subclass | Benzoic acids and derivatives |
| Intermediate Tree Nodes | Hydroxybenzoic acid derivatives - Salicylic acid and derivatives |
| Direct Parent | Salicylic acids |
| Alternative Parents | Benzoic acids Catechols Benzoyl derivatives 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Vinylogous acids Monocarboxylic acids and derivatives Carboxylic acids Organooxygen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Salicylic acid - Benzoic acid - Benzoyl - Catechol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Vinylogous acid - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Aromatic homomonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as salicylic acids. These are ortho-hydroxylated benzoic acids. |
| External Descriptors | dihydroxybenzoic acid |
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| Punto de fusión (°C) | 204-206°C |
|---|---|
| Peso molecular | 154.120 g/mol |
| XLogP3 | 1.200 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 1 |
| Exact Mass | 154.027 Da |
| Monoisotopic Mass | 154.027 Da |
| Topological Polar Surface Area | 77.800 Ų |
| Heavy Atom Count | 11 |
| Formal Charge | 0 |
| Complexity | 157.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Dali Fu, Haodong Wang, Tan Wang, Chunming Xu, Yehua Han. (2023) Structural insights into variation of intramolecular acid site using phase transition experiments and computation. AICHE JOURNAL, 70 (4): (e18342). [PMID:] [10.1002/aic.18342] |
| 2. Xiaomei Yao, Yingbo Fang, Xiaochen Cui, Xian Cheng, Zixia Cheng. (2023) Dielectric Barrier Discharge Plasma Coupled with Cobalt Oxyhydroxide for Methylene Blue Degradation. Toxics, 11 (9): (763). [PMID:37755773] [10.3390/toxics11090763] |
| 3. Fanghua Guo, Li Peng, Hua Xiong, Rong Tsao, Hua Zhang, Li Jiang, Yong Sun. (2023) Bioaccessibility and transport of lentil hull polyphenols in vitro, and their bioavailability and metabolism in rats. FOOD RESEARCH INTERNATIONAL, [PMID:37087206] [10.1016/j.foodres.2023.112634] |
| 4. Huiqun Fan, Mingshun Chen, Taotao Dai, Lizhen Deng, Chengmei Liu, Wei Zhou, Jun Chen. (2023) Phenolic compounds profile of Amomum tsaoko Crevost et Lemaire and their antioxidant and hypoglycemic potential. Food Bioscience, [PMID:] [10.1016/j.fbio.2023.102508] |
| 5. Yunan Zhang, Yu Duan, Jin Su, Lixin Liu, Yanru Feng, Lili Wu, Lei Zhang, Yunjie Zhang, Dongyu Zou, Yingli Liu. (2021) Inspiration for revival of old drugs: improving solubility and avoiding hygroscopicity of pipemidic acid by forming two pharmaceutical salts based on charge-assisted hydrogen bond recognitions. NEW JOURNAL OF CHEMISTRY, 45 (42): (19704-19713). [PMID:] [10.1039/D1NJ03314J] |
| 6. Deying Meng, Huangmei Zhou, Jianhua Xu, Sanjun Zhang. (2021) Studies on the interaction of salicylic acid and its monohydroxy substituted derivatives with bovine serum albumin. CHEMICAL PHYSICS, [PMID:] [10.1016/j.chemphys.2021.111182] |
| 7. Lei Xu, Shaoyu Tang, Dan Li, Xiao Ma, Yunqing Zhu, Jianjiang Lu, Junfeng Niu. (2021) Electrochemical degradation of tris(2-chloroethyl) phosphate by metal-oxide-coated Ti anodes: Kinetics, toxicity and mechanism. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2021.118489] |
| 8. Ren Jingyu, Li Jie, Lv Lei, Wang Jian. (2020) Regeneration of [Bmim]BF4 ionic liquid by ozonation: hydrogen bond roles, synergistic effect, and DFT calculation. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 28 (10): (12909-12917). [PMID:33097991] [10.1007/s11356-020-11298-7] |
| 9. Mingfang Zhu, Hongqing Ye, Mushen Lai, Jianshan Ye, Rui Li, Wenhao Zhang, Huanru Liang, Rongkun Zhu, Huajun Fan, Shi Chen. (2019) The gold nanoparticle sensitized pRGO-MWCNTs grid modified carbon fiber microelectrode as an efficient sensor system for simultaneous detection of three dihydroxybenzoic acid isomers. ELECTROCHIMICA ACTA, [PMID:] [10.1016/j.electacta.2019.134765] |
| 10. Lei Xu, Xiao Ma, Junfeng Niu, Jie Chen, Chengzhi Zhou. (2019) Removal of trace naproxen from aqueous solution using a laboratory-scale reactive flow-through membrane electrode. JOURNAL OF HAZARDOUS MATERIALS, [PMID:31255850] [10.1016/j.jhazmat.2019.05.085] |
| 11. Yitao Li, Xingdong Shi, Zhi Zhang, Yazhou Peng. (2019) Enhanced coagulation by high-frequency ultrasound in Microcystis aeruginosa-laden water: Strategies and mechanisms. ULTRASONICS SONOCHEMISTRY, [PMID:30712852] [10.1016/j.ultsonch.2019.01.022] |
| 12. Haifeng Zhou, Malin Cui, Yuan Zhao, Chan Wang, Qijun Song. (2017) Preparation of Nitrogen and FeP Doped Carbon Nanotubes for Selective and Simultaneous Electrochemical Detection of Dihydroxybenzoic Acid Isomers. ELECTROCHIMICA ACTA, [PMID:] [10.1016/j.electacta.2017.05.045] |
| 13. Cui Xiaoqing, Geng Haoyuan, Guo Huanying, Wang Lei, Zhu Zihan, Zhang Yaqi, Chen Panpan, Wang Xiao, Sun Chenglong. (2024) Visualizing the transdermal delivery of berberine loaded within chitosan microneedles using mass spectrometry imaging. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 416 (29): (6869-6877). [PMID:39400576] [10.1007/s00216-024-05584-3] |
| 14. Fei Qi, Zequan Zeng, Hongbin Lu, Wenhao Si, Yanbiao Liu, Zhanggen Huang, Yuting Niu. (2025) Se/N Co-doped carbon for boosted organic oxidation via periodate activation: Impact of electronic structure reconstruction. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.166563] |
| 15. Xiaoqing Cui, Shiping Chen, Haoyuan Geng, Panpan Chen, Yaqi Zhang, Min Li, Xiao Wang, Chenglong Sun. (2025) Integrating Thiolated Mass Tags with Immuno-Mass Spectrometry Imaging to Map the Spatial Signatures of Functional Proteins in Cancer Tissues. ANALYTICAL CHEMISTRY, [PMID:40839076] [10.1021/acs.analchem.5c01135] |
| 16. Lei Xu, Junfeng Niu, Hongbin Xie, Xiao Ma, Yunqing Zhu, John Crittenden. (2020) Effective degradation of aqueous carbamazepine on a novel blue-colored TiO2 nanotube arrays membrane filter anode. JOURNAL OF HAZARDOUS MATERIALS, [PMID:33254736] [10.1016/j.jhazmat.2020.123530] |
| 17. Yu Qiao, Huajing Zhou, Lingxiang Zhao, Liang He, Rongrong Miao, Zilian Liu, Qingqing Guan. (2025) The selective 3e− ORR pathway induced by differential polarization of surface -OH by adjacent heterodinuclear metals realizes the directed conversion of radicals. JOURNAL OF ENVIRONMENTAL MANAGEMENT, [PMID:40561922] [10.1016/j.jenvman.2025.126248] |