2,4-Pyridinedicarboxylic acid(PCA) - Moligand™, 10mM in DMSO , Inhibitor of lysine demethylase 4A;Inhibitor of lysine demethylase 4E, CAS No.499-80-9, Inhibitor of lysine demethylase 4A;Inhibitor of lysine demethylase 4E

CAS: 499-80-9 Cat. No.: P424300 Peso molecular: 167.12 Beilstein Registry Number: 131631 Número EC: 207-892-2

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

BDBM26113 | NSC-403248 | UNII-AFI29F0TVL | SCHEMBL72377 | Z1236003425 | 2,4-PyridinedicarboxylicAcidHydrate | EN300-82359 | BRD-K36162096-001-04-8 | pyridine carboxylate, 6a | 2,4-Pyridinedicarboxylic acid, >=98.0% | A7429 | GS-6110 | MFCD00006296 | SY013

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

2,4-Pyridinedicarboxylic acid is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. 2,4-Pyridinedicarboxylic acid has been used in a study to determine that ruthenium(II) complexes exert antimetastatic effects on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis. 2,4-Pyridinedicarboxylic acid has been used in a study to develop an assay that represents the first report of a RapidFire mass spectrometery assay for an epigenetics target.

Specifications

Sinónimos

BDBM26113 | NSC-403248 | UNII-AFI29F0TVL | SCHEMBL72377 | Z1236003425 | 2, 4-PyridinedicarboxylicAcidHydrate | EN300-82359 | BRD-K36162096-001-04-8 | pyridine carboxylate, 6a | 2, 4-Pyridinedicarboxylic acid, >=98.0% | A7429 | GS-6110 | MFCD00006296 | SY013

Especificaciones y pureza

Moligand™, 10mM in DMSO

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of lysine demethylase 4A;Inhibitor of lysine demethylase 4E

Nombres e identificadores

• Sonrisas canónicas: C1=CN=C(C=C1C(=O)O)C(=O)O
• IUPAC Name: pyridine-2,4-dicarboxylic acid
• InChIKey: MJIVRKPEXXHNJT-UHFFFAOYSA-N
• INCHI: 1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)
• Isómeros SMILES: C1=CN=C(C=C1C(=O)O)C(=O)O
• WGK Alemania: 3
• CAS alternativo: 207671-42-9
• Peso molecular: 167.12
• Beilstein: 131631
• Reaxy-Rn: 131631
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=131631&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Pyridines and derivatives
      • Subclass Pyridinecarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Pyridines and derivatives
• Subclass: Pyridinecarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyridinecarboxylic acids
• Alternative Parents: Dicarboxylic acids and derivatives Heteroaromatic compounds Carboxylic acids Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyridine carboxylic acid - Dicarboxylic acid or derivatives - Heteroaromatic compound - Azacycle - Carboxylic acid - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as pyridinecarboxylic acids. These are compounds containing a pyridine ring bearing a carboxylic acid group.
• External Descriptors: pyridinedicarboxylic acid

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

EGLN1 Tclin Egl nine homolog 1 (1 Activities)

Discover Target: EGLN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4C Tchem Lysine-specific demethylase 4C (4 Activities)

Discover Target: KDM4C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM5A Tchem Lysine-specific demethylase 5A (1 Activities)

Discover Target: KDM5A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM5C Tchem Lysine-specific demethylase 5C (1 Activities)

Discover Target: KDM5C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ASPH Tchem Aspartyl/asparaginyl beta-hydroxylase (4 Activities)

Discover Target: ASPH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4A Tchem Lysine-specific demethylase 4A (2 Activities)

Discover Target: KDM4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4E Tchem Lysine-specific demethylase 4E (1 Activities)

Discover Target: KDM4E

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGLN2 Tclin Hypoxia-inducible factor prolyl hydroxylase 1 (404 Activities)

Discover Target: EGLN2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

Discover Target: ALDH1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LNCaP (8286 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HeLa (62764 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

Discover Target: KDM4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGLN1 Tclin Egl nine homolog 1 (1702 Activities)

Discover Target: EGLN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGLN3 Tclin Egl nine homolog 3 (250 Activities)

Discover Target: EGLN3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HIF1AN Tbio Hypoxia-inducible factor 1-alpha inhibitor (79 Activities)

Discover Target: HIF1AN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4D Tchem Lysine-specific demethylase 4D (224 Activities)

Discover Target: KDM4D

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4C Tchem Lysine-specific demethylase 4C (1129 Activities)

Discover Target: KDM4C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

Discover Target: KDM4E

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)

Discover Target: BAZ2B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM3A Tchem Lysine-specific demethylase 3A (116 Activities)

Discover Target: KDM3A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM2A Tchem Lysine-specific demethylase 2A (198 Activities)

Discover Target: KDM2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM6B Tchem Lysine-specific demethylase 6B (280 Activities)

Discover Target: KDM6B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PHF8 Tchem Histone lysine demethylase PHF8 (151 Activities)

Discover Target: PHF8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM6A Tchem Lysine-specific demethylase 6A (39 Activities)

Discover Target: KDM6A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BBOX1 Tchem Gamma-butyrobetaine dioxygenase (162 Activities)

Discover Target: BBOX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM5C Tchem Lysine-specific demethylase 5C (224 Activities)

Discover Target: KDM5C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM7A Tchem Lysine-specific demethylase 7 (35 Activities)

Discover Target: KDM7A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FTO Tchem Alpha-ketoglutarate-dependent dioxygenase FTO (473 Activities)

Discover Target: FTO

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM5A Tchem Lysine-specific demethylase 5A (893 Activities)

Discover Target: KDM5A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALKBH5 Tchem RNA demethylase ALKBH5 (134 Activities)

Discover Target: ALKBH5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM5B Tchem Lysine-specific demethylase 5B (814 Activities)

Discover Target: KDM5B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

blaZ Beta-lactamase (285 Activities)

Discover Target: blaZ

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc17a1 Renal sodium-dependent phosphate transport protein 1 (33 Activities)

Discover Target: Slc17a1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Beta-lactamase L1 (242 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

Discover Target: fba

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

blaIMP-1 Metallo beta-lactamase (43 Activities)

Discover Target: blaIMP-1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

REL1 RNA-editing ligase 1, mitochondrial (130 Activities)

Discover Target: REL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A085R Prolyl 4-hydroxylase (72 Activities)

Discover Target: A085R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Sensibilidad: Hygroscopic
• Punto de fusión (°C): 243-246°C
• Peso molecular: 167.120 g/mol
• XLogP3: 0.200
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 167.022 Da
• Monoisotopic Mass: 167.022 Da
• Topological Polar Surface Area: 87.500 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 204.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Ping-Ping Sun, Yi-Ming Li, Yu-Hang Zhang, Hongwei Shi, Fa-Nian Shi.  (2021)  Application of a one dimensional Co-MOP wires on supercapacitors.  INORGANICA CHIMICA ACTA,      [PMID:] [10.1016/j.ica.2021.120337]

2. Ru-Ru Gao, Wei Dong.  (2020)  ATP and lanthanide ions derived coordination polymer nanoparticles as a novel family of versatile materials: Color-tunable emission, artificial tongues and logic devices.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2020.105753]

3. Shi-Fan Xue, Jing-Fei Zhang, Zi-Han Chen, Xin-Yue Han, Min Zhang, Guoyue Shi.  (2018)  Multifunctional fluorescent sensing of chemical and physical stimuli using smart riboflavin-5′-phosphate/Eu3+ coordination polymers.  ANALYTICA CHIMICA ACTA,      [PMID:29475476] [10.1016/j.aca.2018.01.038]

4. Qi-Xian Wang, Shi-Fan Xue, Zi-Han Chen, Shi-Hui Ma, Shengqiang Zhang, Guoyue Shi, Min Zhang.  (2017)  Dual lanthanide-doped complexes: the development of a time-resolved ratiometric fluorescent probe for anthrax biomarker and a paper-based visual sensor.  BIOSENSORS & BIOELECTRONICS,      [PMID:28324858] [10.1016/j.bios.2017.03.027]

5. Shuo Li, Jiahuan Luo, Jing Wang, Yue Zhu, Jingkang Feng, Ning Fu, Hao Wang, Yao Guo, Dayong Tian, Yong Zheng, Shixiong Sun, Chuanxiang Zhang, Kongyao Chen, Shichun Mu, Yunhui Huang.  (2024)  Hybrid supercapacitors using metal-organic framework derived nickel-sulfur compounds.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:38718580] [10.1016/j.jcis.2024.04.205]

6. Shuming Yu, Hao Zhao, Yuxin Wang, Xiaoshi Lang, Tan Wang, Tingting Qu, Lan Li, Chuangang Yao, Kedi Cai.  (2024)  Ordered layered manganese-based metal–organic frameworks induce 2D growth of discharge products via LiO2 adsorbent for high performance lithium–oxygen batteries.  APPLIED ORGANOMETALLIC CHEMISTRY,  38  (11): (e7658).  [PMID:] [10.1002/aoc.7658]

7. Shuming Yu, Kedi Cai, Hao Zhao, Tan Wang, Tingting Qu, Lan Li, Jianbin Li, Chuangang Yao, Xiaoshi Lang.  (2025)  Adjusting the electron configuration of MOFs-derived Ag/MnO1.1@C via electron transfer strategy to achieve a high-performance catalyst for potassium-oxygen batteries.  APPLIED SURFACE SCIENCE,      [PMID:] [10.1016/j.apsusc.2025.163863]