2,4-Tiazolidinediona - ≥99% , CAS No.2295-31-0

CAS: 2295-31-0 Cat. No.: T109725 Peso molecular: 117.13 Beilstein Registry Number: 110700 Número EC: 218-941-2 PubChem CID: 5437

GRADE & PURITY ≥99%

Synonyms

AKOS025397012 | SR-01000945204 | thiazolidine-2,4-dione | 1,3-Thiazolidine-2,4-dione # | 2,4 thiazolidinedione | NSC 6745 | SY001546 | HY-59272 | 2-THIAZOLIN-4-ONE, 2-HYDROXY- | Thiazolidindione | 2,4(3H,5H)-Thiazoledione | 2,4thiazolidinedione | 2,4-THIA

Storage

Argon charged,Room temperature

Shipped In

Normal

Descripción general

la 2,4-Thiazolidinediona es un inhibidor enzimático.

Specifications

Sinónimos

AKOS025397012 | SR-01000945204 | thiazolidine-2, 4-dione | 1, 3-Thiazolidine-2, 4-dione # | 2, 4 thiazolidinedione | NSC 6745 | SY001546 | HY-59272 | 2-THIAZOLIN-4-ONE, 2-HYDROXY- | Thiazolidindione | 2, 4(3H, 5H)-Thiazoledione | 2, 4thiazolidinedione | 2, 4-THIA

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

Agonista PPARγ. Agente sensibilizador a la insulina. Inhibe la angiogénesis inducida por VEGF. Induce la apoptosis en líneas celulares cancerosas. Muestra potentes efectos antidiabéticos de tipo 2 in vivo. Activo por vía oral.

Condiciones de almacenamiento de almacenamiento

Argon charged, Room temperature

Enviado en

Normal

Nota

Siempre que sea posible, prepare y utilice las soluciones el mismo día. Sin embargo, si necesita preparar soluciones madre con antelación, le recomendamos que almacene la solución como alícuotas en viales herméticamente cerrados a -20°C. Por lo general, podrán utilizarse durante un mes. Antes de su uso, y antes de abrir el vial, le recomendamos que deje que el producto se equilibre a temperatura ambiente durante al menos 1 hora. ¿Necesita más consejos sobre solubilidad, uso y manipulación? Visite nuestra página de preguntas frecuentes (FAQ) para obtener más información.

Pureza

≥99%

Nombres e identificadores

• Pubchem Sid: 488179900
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488179900
• Sonrisas canónicas: C1C(=O)NC(=O)S1
• IUPAC Name: 1,3-thiazolidine-2,4-dione
• InChIKey: ZOBPZXTWZATXDG-UHFFFAOYSA-N
• INCHI: 1S/C3H3NO2S/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
• Isómeros SMILES: C1C(=O)NC(=O)S1
• WGK Alemania: 3
• RTECS: XJ5775000
• PubChem CID: 5437
• Peso molecular: 117.13
• Beilstein: 110700
• Reaxy-Rn: 110700

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Azolidines
      • Subclass Thiazolidines
        • Level5 Thiazolidinones
          • Level6 Thiazolidinediones

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Azolidines
• Subclass: Thiazolidines
• Intermediate Tree Nodes: Thiazolidinones
• Direct Parent: Thiazolidinediones
• Alternative Parents: Dicarboximides Thiocarbamic acid derivatives Organic carbonic acids and derivatives Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Thiazolidinedione - Dicarboximide - Thiocarbamic acid derivative - Carbonic acid derivative - Azacycle - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aliphatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as thiazolidinediones. These are heterocyclic compounds containing a thiazolidine ring which bears two ketone groups.
• External Descriptors: thiazolidenedione

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

F2 Tclin Thrombin (11687 Activities)

Discover Target: F2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GSK3A Tclin Glycogen synthase kinase-3 (736 Activities)

Discover Target: GSK3A

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Objetivos asociados (no humanos)

Pseudomonas aeruginosa (123386 Activities)

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Micrococcus luteus (7463 Activities)

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Staphylococcus aureus (210822 Activities)

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Escherichia coli (133304 Activities)

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Serratia marcescens (3237 Activities)

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Bacillus subtilis (32866 Activities)

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Enterococcus faecalis (29875 Activities)

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Mycolicibacterium smegmatis (8003 Activities)

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Candida albicans (78123 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in water; Soluble in Ethanol
• Sensibilidad: Air Sensitive
• Punto de ebullición (°C): 178-179°C
• Punto de fusión (°C): 123-126°C
• Peso molecular: 117.130 g/mol
• XLogP3: 0.100
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 116.988 Da
• Monoisotopic Mass: 116.988 Da
• Topological Polar Surface Area: 71.500 Ų
• Heavy Atom Count: 7
• Formal Charge: 0
• Complexity: 122.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1