2-Amino-6-methylmercaptopurine - ≥95% , CAS No.1198-47-6

CAS: 1198-47-6 Cat. No.: A166390 Peso molecular: 181.22 Número EC: 214-833-4

GRADE & PURITY ≥95%

Synonyms

Oprea1_233867 | CCG-53733 | thioguanine S-methylether | 2-Amino-6-methylthiopurine | S6-Methyl-6-thioguanine | QNV75HJN3A | 6-(methylsulfanyl)-7H-purin-2-amine | 6-methylsulfanyl-7H-purin-2-amine | NSC 29420 | NSC29420 | NSC-29420 | HMS608L06 | 2-Amino-6-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

2-Amino-6-methylmercaptopurine is a 2-amino-6-alkyldithiopurine that has been used with other 6-position carbon analogues to study brain specific diazepam binding.

2-Amino-6-methylmercaptopurine (6-MTG) has been used as a supplement in Dulbecco′s modified Eagles medium (DMEM) medium for the selection of gpt-expressing recombinant virus mCMVhMIEPE-gpt.lacZ (cytomegalovirus major immediate-early promotor-enhancer complex-gpt.lacz). It has also been used as a standard in high performance liquid chromatography (HPLC) to assess the activity of thiopurine methyltransferase (TPMT) enzyme.

Specifications

Sinónimos

Oprea1_233867 | CCG-53733 | thioguanine S-methylether | 2-Amino-6-methylthiopurine | S6-Methyl-6-thioguanine | QNV75HJN3A | 6-(methylsulfanyl)-7H-purin-2-amine | 6-methylsulfanyl-7H-purin-2-amine | NSC 29420 | NSC29420 | NSC-29420 | HMS608L06 | 2-Amino-6-

Especificaciones y pureza

≥95%

Mecanismos bioquímicos y fisiológicos

2-Amino-6-methylmercaptopurine is synthesized from 6-mercaptopurine by the S methylation activity of thiopurine methyl transferase (TMPT) enzyme.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥95%

Nombres e identificadores

• Sonrisas canónicas: CSC1=NC(=NC2=C1NC=N2)N
• IUPAC Name: 6-methylsulfanyl-7H-purin-2-amine
• InChIKey: YEGKYFQLKYGHAR-UHFFFAOYSA-N
• INCHI: 1S/C6H7N5S/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)
• Isómeros SMILES: CSC1=NC(=NC2=C1NC=N2)N
• Peso molecular: 181.22
• Reaxy-Rn: 10665
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10665&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Imidazopyrimidines
      • Subclass Purines and purine derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Imidazopyrimidines
• Subclass: Purines and purine derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: 6-thiopurines
• Alternative Parents: Aminopyrimidines and derivatives Alkylarylthioethers Imidazoles Heteroaromatic compounds Sulfenyl compounds Azacyclic compounds Primary amines Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 6-thiopurine - Aryl thioether - Aminopyrimidine - Alkylarylthioether - Pyrimidine - Azole - Imidazole - Heteroaromatic compound - Azacycle - Thioether - Sulfenyl compound - Primary amine - Organosulfur compound - Organonitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Amine - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as 6-thiopurines. These are compounds containing a purine that carries a thiol group at the 6-position. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

Pnp Purine nucleoside phosphorylase (4 Activities)

Discover Target: Pnp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO (Slightly), Methanol (Slightly)
• Punto de fusión (°C): 228-230°C
• Peso molecular: 181.220 g/mol
• XLogP3: 0.300
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 181.042 Da
• Monoisotopic Mass: 181.042 Da
• Topological Polar Surface Area: 106.000 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 166.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1