2-Methylpyrazine - ≥98%(GC) , CAS No.109-08-0

CAS: 109-08-0 Cat. No.: M158369 Peso molecular: 94.12 Beilstein Registry Number: 105778 Número EC: 203-645-8
Disponible para pedir
GRADE & PURITY ≥98%(GC)
Synonyms
2-Methylpyrazine, >=99% | NSC49138 | NSC-49138 | 2-METHYLPYRAZINE [FHFI] | 5-methylpyrazine | RVC6500U9C | 2-Methylpyrazine, European Pharmacopoeia (EP) Reference Standard | 2-Methylpyrazine, Pharmaceutical Secondary Standard; Certified Reference Material
Storage
Argon charged,Room temperature
Shipped In
Normal
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
25g
M158369-25g
6

11,90US$

17,90US$
Guardar 6,00 US$ (33.52%)
100g
M158369-100g
4

38,90US$

58,90US$
Guardar 20,00 US$ (33.96%)
500g
M158369-500g
1

104,90US$

157,90US$
Guardar 53,00 US$ (33.57%)
Enter a quantity for the sizes you want to add.
🧪

Why this grade

≥98%(GC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Argon charged,Room temperature Ships Normal Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 30 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Product Description:

2-Methylpyrazine is an alkyl-substituted pyrazine used as a key intermediate in the synthesis of pyrazineamide, an anti-tubercular drug.

Product Application:

2-Methylpyrazine can be used: As a ligand to prepare coordination polymer [Ag(CF3CO2)(2-Me-Pyz)], wherein 2-Me-Pyz is 2-methylpyrazine. To prepare 2-cyanopyrazine via ammoxidation reaction using MoVPO catalyst. As a ligand in the synthesis of fluorescent silver(I)-saccharinato complex, which exhibits blue luminescence at room temperature.

Specifications

Sinónimos
2-Methylpyrazine, >=99% | NSC49138 | NSC-49138 | 2-METHYLPYRAZINE [FHFI] | 5-methylpyrazine | RVC6500U9C | 2-Methylpyrazine, European Pharmacopoeia (EP) Reference Standard | 2-Methylpyrazine, Pharmaceutical Secondary Standard; Certified Reference Material
Especificaciones y pureza
≥98%(GC)
Condiciones de almacenamiento de almacenamiento
Argon charged, Room temperature
Enviado en
Normal
Pureza
≥98%(GC)
Nombres e identificadores
Pubchem Sid488180635
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488180635
Sonrisas canónicasCC1=NC=CN=C1
IUPAC Name2-methylpyrazine
InChIKeyCAWHJQAVHZEVTJ-UHFFFAOYSA-N
INCHI1S/C5H6N2/c1-5-4-6-2-3-7-5/h2-4H,1H3
Isómeros SMILES CC1=NC=CN=C1
WGK Alemania 3
RTECS UQ3675000
Peso molecular 94.12
Beilstein 105778
Reaxy-Rn 105778
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=105778&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClaseDiazines
SubclassPyrazines
Intermediate Tree Nodes Not available
Direct ParentPyrazines
Alternative Parents Heteroaromatic compounds  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Pyrazine - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteromonocyclic compound
DescripciónThis compound belongs to the class of organic compounds known as pyrazines. These are compounds containing a pyrazine ring, which is a six-member aromatic heterocycle, that consists of two nitrogen atoms (at positions 1 and 4) and four carbon atoms.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

27 results found

Lot NumberCertificate TypeFechaArticulo
J2514078Certificate of AnalysisMay 27, 2024 M158369
C2626128Certificate of AnalysisMay 27, 2024 M158369
H2416428Certificate of AnalysisMay 27, 2024 M158369
H2416391Certificate of AnalysisMay 27, 2024 M158369
D2416392Certificate of AnalysisMar 15, 2024 M158369
D2416393Certificate of AnalysisMar 15, 2024 M158369
L2308449Certificate of AnalysisNov 27, 2023 M158369
L2308451Certificate of AnalysisNov 24, 2023 M158369
L2308450Certificate of AnalysisNov 24, 2023 M158369
A2431235Certificate of AnalysisNov 24, 2023 M158369
I2305448Certificate of AnalysisAug 29, 2023 M158369
I2305447Certificate of AnalysisAug 28, 2023 M158369
I2305446Certificate of AnalysisAug 28, 2023 M158369
I2305445Certificate of AnalysisAug 28, 2023 M158369
G2320904Certificate of AnalysisJun 28, 2023 M158369
G2320900Certificate of AnalysisJun 28, 2023 M158369
G2320898Certificate of AnalysisJun 28, 2023 M158369
G2320897Certificate of AnalysisJun 28, 2023 M158369
G2320895Certificate of AnalysisJun 28, 2023 M158369
G2320894Certificate of AnalysisJun 28, 2023 M158369
B2303479Certificate of AnalysisNov 17, 2022 M158369
B2303478Certificate of AnalysisNov 17, 2022 M158369
B2303462Certificate of AnalysisNov 17, 2022 M158369
B2303401Certificate of AnalysisNov 17, 2022 M158369
H2205324Certificate of AnalysisJun 15, 2022 M158369
H2205325Certificate of AnalysisJun 15, 2022 M158369
H2205323Certificate of AnalysisJun 15, 2022 M158369

Show more ⌵

Propiedades químicas y físicas
SolubilidadFully miscible in water.
SensibilidadAir sensitive
Índice de refracción1.50
Punto de inflamación (°F)122 °F
Punto de inflamación (°C)50°C
Punto de ebullición (°C)135°C
Punto de fusión (°C)-29°C(lit.)
Peso molecular94.110 g/mol
XLogP30.200
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass94.0531 Da
Monoisotopic Mass94.0531 Da
Topological Polar Surface Area25.800 Ų
Heavy Atom Count7
Formal Charge0
Complexity54.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Preguntas frecuentes y artículos
Citations of This Product
Referencias
1. Xinjing Li, Yishun Yao, Xue Xia, Foxin Zhang, Jingyang Yu, Heping Cui, Yunwei Niu, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2023)  Maillard Reaction Process and Characteristic Volatile Compounds Formed During Secondary Thermal Degradation Monitored via the Change of Fluorescent Compounds in the Reaction of Xylose–Corn Protein Hydrolysate.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:38115213] [10.1021/acs.jafc.3c08082]
2. Yue Luo, Siyue Zhu, Jie Peng, Heping Cui, Qingrong Huang, Baojun Xu, Chi-Tang Ho.  (2023)  Feasibility Study of Amadori Rearrangement Products of Glycine, Diglycine, Triglycine, and Glucose as Potential Food Additives for Production, Stability, and Flavor Formation.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:38109376] [10.1021/acs.jafc.3c06250]
3. Hao Zhang, Mingyao Wang, Meiyu Qian, Hongquan Wei.  (2023)  Odor familiarity and improvement of olfactory identification test in Chinese population.  Frontiers in Psychology,      [PMID:37908819] [10.3389/fpsyg.2023.1278668]
4. Tong Zhou, Xue Xia, Heping Cui, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2023)  Promotion or Inhibition Effects of Exogenous Glutathione-Degraded Amino Acids on the Formation of 2,3-Butanedione and Pyrazines via Varied Pathways of Interaction with α-Dicarbonyl Compounds Derived from N-(1-Deoxy-d-xylulos-1-yl)-alanine.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:37737140] [10.1021/acs.jafc.3c04424]
5. D.-Y. Li, Y.-H. Liu, Q. Wang, X.-W. Lei, C.-Y. Yue, Z.-H. Jing.  (2023)  Zero-dimensional hybrid zinc halides with blue light emissions.  Materials Today Chemistry,      [PMID:] [10.1016/j.mtchem.2023.101604]
6. Tong Zhou, Xue Xia, Heping Cui, Yun Zhai, Foxin Zhang, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2023)  Cysteine-Induced pH-Dependent Formation of Thiols and Sulfides or 2-Acetylthiazole and Pyrazines during Thermal Treatment of N-(1-Deoxy-d-xylulos-1-yl)-alanine.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:36696632] [10.1021/acs.jafc.2c08360]
7. Tong Zhou, Xue Xia, Heping Cui, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Competitive Formation of 2,3-Butanedione and Pyrazines through Intervention of Added Cysteine during Thermal Processing of Alanine-Xylose Amadori Compounds.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:36444759] [10.1021/acs.jafc.2c07026]
8. Shibin Deng, Yun Zhai, Heping Cui, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Mechanism of Pyrazine Formation Intervened by Oxidized Methionines during Thermal Degradation of the Methionine–Glucose Amadori Compound.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:36342227] [10.1021/acs.jafc.2c06458]
9. Meichen Liu, Jingyang Yu, Tong Zhou, Huaneng Xu, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Formation Priority of Pyrazines and 2-Acetylthiazole Dependent on the Added Cysteine and Fragments of Deoxyosones during the Thermal Process of the Glycine–Ribose Amadori Compound.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:36070497] [10.1021/acs.jafc.2c04874]
10. Xiaojing Zhang, Pei Gao, Wenshui Xia, Qixing Jiang, Shaoquan Liu, Yanshun Xu.  (2022)  Characterization of key aroma compounds in low-salt fermented sour fish by gas chromatography-mass spectrometry, odor activity values, aroma recombination and omission experiments.  FOOD CHEMISTRY,      [PMID:35908468] [10.1016/j.foodchem.2022.133773]
11. Linhui Feng, Heping Cui, Pusen Chen, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Promoted Formation of Pyrazines and Sulfur-Containing Volatile Compounds through Interaction of Extra-Added Glutathione or Its Constituent Amino Acids and Secondary Products of Thermally Degraded N-(1-Deoxy-d-ribulos-1-yl)-Glutathione.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:35838405] [10.1021/acs.jafc.2c02949]
12. Xue Xia, Yun Zhai, Heping Cui, Han Zhang, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Structural diversity and concentration dependence of pyrazine formation: Exogenous amino substrates and reaction parameters during thermal processing of l-alanyl-l-glutamine Amadori compound.  FOOD CHEMISTRY,      [PMID:35594769] [10.1016/j.foodchem.2022.133144]
13. Chuncheng Lin, Jiamin Zhou, Zhangfan Zheng, Jinzhu Chen.  (2022)  An efficient approach to biomass-based tertiary amines by direct and consecutive reductive amination of furfural.  JOURNAL OF CATALYSIS,      [PMID:] [10.1016/j.jcat.2022.04.016]
14. Caixing Pan, Heping Cui, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Exogenous glutamic acid effectively involved in N-(1-deoxy-D-galulos-1-yl)-glutamic acid degradation for simultaneous improvement of both milk-like and baking flavor.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2022.101697]
15. Shibin Deng, Heping Cui, Khizar Hayat, Yun Zhai, Qiang Zhang, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Comparison of pyrazines formation in methionine/glucose and corresponding Amadori rearrangement product model.  FOOD CHEMISTRY,      [PMID:35245757] [10.1016/j.foodchem.2022.132500]
16. Ziyan Wang, Heping Cui, Mengyu Ma, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Controlled Formation of Pyrazines: Inhibition by Ellagic Acid Interaction with N-(1-Deoxy-d-xylulos-1-yl)-glycine and Promotion through Ellagic Acid Oxidation.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:35089027] [10.1021/acs.jafc.1c07391]
17. Tingting Wang, Yu Wu, Ying Han, Peiwen Xu, Yijun Pang, Xinzhen Feng, Hao Yang, Weijie Ji, Tao Cheng.  (2021)  Hofmann-Type Metal–Organic Framework Nanosheets for Oxygen Evolution.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.1c03619]
18. Junyi Wang, Ruifang Wang, Yan Gao, Jing Wang, Lina Qiao, Huijuan Li, Guohua Zhao, Ning Zhang, Hitao Chen, Jie Sun, Shuqi Wang.  (2025)  Analysis of dynamic flavor changes of volatile and non-volatile fractions analysis of black qingke (Hordeum vulgare L. var. nudum Hook. f.) during steaming process.  JOURNAL OF FOOD SCIENCE,  90  (2): (e17660).  [PMID:39929602] [10.1111/1750-3841.17660]
19. Yimeng Ren, Longzhu Zhou, Chaohua Tang, Jing Li, Yujie Shi, Qingyu Zhao, Junmin Zhang, Yueyu Bai.  (2025)  Characterization of lipid distribution and volatile profile in high-marbling beef of Jiaxian Red cattle.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,      [PMID:] [10.1016/j.jfca.2025.107374]
20. Xiao Jia, Hongli Cui, Song Qin, Jingnan Ren, Zhifeng Zhang, Qi An, Nawei Zhang, Jinchu Yang, Yongfeng Yang, Gang Fan, Siyi Pan.  (2024)  Characterizing and decoding the key odor compounds of Spirulina platensis at different processing stages by sensomics.  FOOD CHEMISTRY,      [PMID:39182338] [10.1016/j.foodchem.2024.140944]
21. Han Zhang, Heping Cui, Xue Xia, Shahzad Hussain, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2024)  Control Formation of Furans and Pyrazines Resulting from Dual Glycation Sites in Nα,Nε-Di(1-deoxy-d-xylulos-1-yl)lysine via Elevating Thermal Degradation Temperatures.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:39481093] [10.1021/acs.jafc.4c07733]
22. Han Zhang, Heping Cui, Xue Xia, Shahzad Hussain, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2025)  Dual role of exogenous xylose in regulating pyrazines and furans formation during the thermal degradation of Nα,Nε-di(1-deoxy-d-xylulos-1-yl)lysine through temperature, reaction time, and xylose concentration control.  FOOD CHEMISTRY,      [PMID:40086376] [10.1016/j.foodchem.2025.143828]
23. Yucen Chen, Xinshuo Wang, Yahui Gao, Caleb John Swing, Jingyang Yu, Heping Cui, Shuqin Xia.  (2024)  Effect of microwave and conduction heating on the adsorption ability of myofibrillar protein to pyrazine flavor compounds.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2024.104127]
24. Mengmeng Ji, Yi Chen, Yufei Hu, Gongke Li.  (2024)  Rapid differentiation of coffee bean origin by ketones-based cyclic cataluminescence method.  TALANTA,      [PMID:39613488] [10.1016/j.talanta.2024.127261]
25. Mingzhu Zhou, Yiting Lu, Jinyu Yu, Chao Wang, Wei Yu, Liu Shi, Wenjin Wu, Lan Wang, Yu Qiao.  (2025)  Characterization of off-flavor compounds in ready-to-heat roasted catfish after reheating by sensomics approach.  Food Chemistry-X,      [PMID:40831966] [10.1016/j.fochx.2025.102872]
26. Shuxing Zhou, Chunlin Li, Li Li, Feng Xie, Karyne M. Rogers, Yuwei Yuan, Jun Huang.  (2025)  Differentiating volatile compounds in soy sauce that regulate the attractiveness of flesh flies (Parasarcophaga dux).  FOOD CHEMISTRY,      [PMID:41027210] [10.1016/j.foodchem.2025.146504]
27. Wenghua Tong, XingYan Liu, Ying Yang, Yan Wang, Zhijiu Huang, Hongjun Fan.  (2025)  Molecular and technical aspects on the interaction of bovine serum albumin with pyrazine derivatives: From molecular docking to spectroscopy study.  JOURNAL OF FOOD SCIENCE,  90  (2): (e70017).  [PMID:39898927] [10.1111/1750-3841.70017]
28. Weiming Hua, Huan Liu, Qichao Fei, Jincheng Wu, Xiangru Wei, Matta Ebaid, Runmi Tao, Dengyong Liu, Shengmei Gai.  (2025)  Formation of volatile compounds in mutton during air fryer roasted mutton by means of GC–MS and GC-IMS.  FOOD RESEARCH INTERNATIONAL,      [PMID:40356175] [10.1016/j.foodres.2025.116404]
29. Jian Zou, Gang Wang, Shuyu Duan, Chenyi Shi, Xiaobing Yun, Xiuhan Yang, Zhe Du, Huan Qiu, Winniford Bill.  (2025)  Development of an Aroma Permeation Measurement Method Using Dynamic SPME-GC-FID Technique Coupled to a Flow-Cell.  PACKAGING TECHNOLOGY AND SCIENCE,      [PMID:] [10.1002/pts.2900]
30. Tong Zhou, Qingqing Chai, Man Zhang, Heping Cui, Ahmad Mohammad, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2025)  Role of exogenous xylose during its co-heating with alanine-xylose Amadori compound: Competitively promoting 2-furfural formation and limiting pyrazines generation.  FOOD CHEMISTRY,      [PMID:40393223] [10.1016/j.foodchem.2025.144764]
Calculadoras de soluciones
Reseñas

Reseñas de cliente

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.