20-HETE - Moligand™, ≥98%, a solution in ethanol , Activator of TRPC6, CAS No.79551-86-3, Activator of TRPC6

CAS: 79551-86-3 Cat. No.: H126988 Peso molecular: 320.47

GRADE & PURITY Moligand™, ≥98%, a solution in ethanol

Synonyms

20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid | CHEBI:34306 | Q21099666 | SR-01000946981-1 | DTXSID601009895 | 20-hydroxy-5,8,11,14-eicosatetraenoate | 20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate | HY-15598 | 20-Hete | 20-Hydroxyarachidonic acid | 20-Hydr

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid

20-HETE is supplied as a solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. Solvents such as ethanol, DMSO, and dimethyl formamide purged with an inert gas can be used. 20-HETE is miscible in these solvents.

Specifications

Sinónimos

20-hydroxy-5Z, 8Z, 11Z, 14Z-eicosatetraenoic acid | CHEBI:34306 | Q21099666 | SR-01000946981-1 | DTXSID601009895 | 20-hydroxy-5, 8, 11, 14-eicosatetraenoate | 20-hydroxy-5Z, 8Z, 11Z, 14Z-eicosatetraenoate | HY-15598 | 20-Hete | 20-Hydroxyarachidonic acid | 20-Hydr

Especificaciones y pureza

Moligand™, ≥98%, a solution in ethanol

Mecanismos bioquímicos y fisiológicos

Description:IC50 Value: N/A20-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450-derived arachidonic acid metabolite that has been shown to increase smooth muscle contractions and proliferation, stimulate endothelial dysfunction and activation a

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

ACTIVATOR

Mecanismo de acción

Activator of TRPC6

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: C(CCC=CCC=CCC=CCC=CCCCC(=O)O)CCO
• IUPAC Name: (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid
• InChIKey: NNDIXBJHNLFJJP-DTLRTWKJSA-N
• INCHI: 1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10-
• Isómeros SMILES: C(CC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O)CCO
• WGK Alemania: 1
• Peso molecular: 320.47
• Reaxy-Rn: 27451915
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=27451915&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Clase Fatty Acyls
      • Subclass Fatty acids and conjugates

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Clase: Fatty Acyls
• Subclass: Fatty acids and conjugates
• Intermediate Tree Nodes: Not available
• Direct Parent: Long-chain fatty acids
• Alternative Parents: Hydroxy fatty acids Unsaturated fatty acids Straight chain fatty acids Monocarboxylic acids and derivatives Carboxylic acids Primary alcohols Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Long-chain fatty acid - Hydroxy fatty acid - Unsaturated fatty acid - Straight chain fatty acid - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Primary alcohol - Organooxygen compound - Carbonyl group - Alcohol - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as long-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms.
• External Descriptors: Hydroxy/hydroperoxyeicosatetraenoic acids

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

TRPC6 Tchem Short transient receptor potential channel 6 (0 Activities)

Discover Target: TRPC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

Discover Target: PTGS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)

Discover Target: PTGS2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: 25°C: DMSO
• Sensibilidad: Air sensitive；Light sensitive
• Punto de inflamación (°F): 57.2 °F
• Punto de inflamación (°C): 14 °C
• Peso molecular: 320.500 g/mol
• XLogP3: 4.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 15
• Exact Mass: 320.235 Da
• Monoisotopic Mass: 320.235 Da
• Topological Polar Surface Area: 57.500 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 378.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 4
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 4
• Covalently-Bonded Unit Count: 1

Referencias

1. Pengfei Tang, Houli Jiang, Ze Zheng, Zhiqi Xiao, Lingyi Kong, Jun Luo.  (2025)  Limonoid walrobsin A alleviates LPS-induced septic acute kidney injury through modulating inflammatory microenvironment by targeting G protein-coupled receptor 75.  PHYTOMEDICINE,      [PMID:41353881] [10.1016/j.phymed.2025.157613]