4-Chloro-1-naphthol - ≥99% , CAS No.604-44-4

CAS: 604-44-4 Cat. No.: C109038 Peso molecular: 178.61 Beilstein Registry Number: 509750 Número EC: 210-068-5

GRADE & PURITY ≥99%

Synonyms

4C1N 4-CN | 4-Chloro-1-naphthol, >=95.0% (HPLC), tablet (~32 mg each) | 4-Chloro-1-naphthol, for analytical purposes, >=99.0% | 4-chloronaphthol | Z104477546 | LVSPDZAGCBEQAV-UHFFFAOYSA- | C2291 | STR01788 | 1-chloro-4-naphthol | C-5180 | SY045975 | 1-Chl

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

4-Chloro-1-naphthol is primarily used for the detection of proteins, it gives a characteristic purple precipitate and the reactions are easily controllable. It can be used as a substitute for benzidine compounds, which are considered to be carcinogenic.

Specifications

Sinónimos

4C1N 4-CN | 4-Chloro-1-naphthol, >=95.0% (HPLC), tablet (~32 mg each) | 4-Chloro-1-naphthol, for analytical purposes, >=99.0% | 4-chloronaphthol | Z104477546 | LVSPDZAGCBEQAV-UHFFFAOYSA- | C2291 | STR01788 | 1-chloro-4-naphthol | C-5180 | SY045975 | 1-Chl

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

Chromogenic peroxidase substrate that results in a precipitate that is blue to blue-purple in color and can be observed visually. Used for both western blotting and immunohistochemical staining. Can be used as a substitute in the myeloperoxidase stain for

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥99%

Nombres e identificadores

• Pubchem Sid: 488181433
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488181433
• Sonrisas canónicas: C1=CC=C2C(=C1)C(=CC=C2Cl)O
• IUPAC Name: 4-chloronaphthalen-1-ol
• InChIKey: LVSPDZAGCBEQAV-UHFFFAOYSA-N
• INCHI: 1S/C10H7ClO/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6,12H
• Isómeros SMILES: C1=CC=C2C(=C1)C(=CC=C2Cl)O
• WGK Alemania: 3
• Peso molecular: 178.61
• Beilstein: 509750
• Reaxy-Rn: 509750
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=509750&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Naphthalenes
      • Subclass Naphthols and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Naphthalenes
• Subclass: Naphthols and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Naphthols and derivatives
• Alternative Parents: Chloronaphthalenes 1-hydroxy-2-unsubstituted benzenoids Aryl chlorides Organooxygen compounds Organochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Chloronaphthalene - 1-naphthol - 1-hydroxy-2-unsubstituted benzenoid - Aryl halide - Aryl chloride - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Organochloride - Organohalogen compound - Aromatic homopolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as naphthols and derivatives. These are naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in Methanol
• Sensibilidad: Air & Light Sensitive
• Punto de fusión (°C): 117-120°C
• Peso molecular: 178.610 g/mol
• XLogP3: 3.900
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 178.019 Da
• Monoisotopic Mass: 178.019 Da
• Topological Polar Surface Area: 20.200 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 160.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Xiaoran Tan, Jiaxin Liang, Haihan Yu, Yuanyuan Chen, Li Shan, Shenguang Ge, Lina Zhang, Li Li, Jinghua Yu.  (2023)  Magnetic field enabled spin-state reconfiguration for highly sensitive paper-based photoelectrochemical bioanalysis.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.144626]

2. Jia Ding, Fei Liu, Chunling Qi, Yunlei Zhou, Huanshun Yin, Shiyun Ai.  (2021)  Enhanced photoactivity of perovskite Bi4NbO8Cl/PTC-NH2 heterojunction and its application for photoelectrochemical sensing of DNA hydroxymethylation.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2021.130211]

3. Saibo Chen, Hao Nan, Xuan Zhang, Yuting Yan, Zhou Zhou, Ying Zhang, Kun Wang.  (2017)  One-step hydrothermal treatment to fabricate Bi2WO6-reduced graphene oxide nanocomposites for enhanced visible light photoelectrochemical performance.  Journal of Materials Chemistry B,  5  (20): (3718-3727).  [PMID:32264060] [10.1039/C6TB02493A]

4. Su Yuan, Zhang Ziyu, Zhang Hongfang.  (2025)  A dual-mode biosensor for microRNA detection based on DNA tetrahedron-gated nanochannels.  MICROCHIMICA ACTA,  192  (2): (1-9).  [PMID:39827251] [10.1007/s00604-025-06950-3]

5. Xianchen Hu, Yali Xu, Yuexi Lin, Xinghe Chen, Junshan Lin.  (2025)  Tyramine–enzyme conjugate repeats for an interdigitated capacitance immunosensing array in the detection of neuroblastoma biomarker neuron-specific enolase.  ANALYST,  150  (5): (914-921).  [PMID:39881580] [10.1039/D4AN01442A]

6. Yidong Zhou, Zhijian Ke, Hangting Ye, Mengting Hong, Yifei Xu, Mingliang Zhang, Wankui Jiang, Qing Hong.  (2020)  Hydrolase CehA and a Novel Two-Component 1-Naphthol Hydroxylase CehC1C2 are Responsible for the Two Initial Steps of Carbaryl Degradation in Rhizobium sp. X9.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:33264024] [10.1021/acs.jafc.0c03845]

7. Xiaoyu Yang, Youlin Tang, Runzi Zhang, Yao Liu, Mengjun Wang, Juan Zhang, Yi He.  (2025)  A novel SERS aptasensor based on Au-Mn-Cu nanozyme induced catalytic precipitation reactions combining with catalytic hairpin assembly strategy for sensitive detection of chloramphenicol.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,      [PMID:] [10.1016/j.jfca.2025.108402]

8. Lihui Zhao, Can Jin, He Liu, Zhaozhe Yang, Yupeng Liu.  (2026)  Natural bamboo-derived porous carbon activates PMS for BPA degradation: A singlet oxygen-dominated nonradical pathway.  Journal of Environmental Sciences,      [PMID:] [10.1016/j.jes.2026.01.022]

9. Qinyan Chen, Qiong Lin, Yibin Zeng, Haining Li, Xiao Han, Dianping Tang, Gaoda Ju.  (2026)  Pencil-drawn paper-based portable photoelectrochemical immunoassay of carbohydrate antigen 19-9 based on TiO2 hollow cube homogeneous junctions.  ANALYTICA CHIMICA ACTA,      [PMID:41813360] [10.1016/j.aca.2026.345288]

10. Xie Zhoujian, Wu Jiawen, Huang Kejing, Tan Xuecai.  (2026)  Strand displacement–triggered biocatalytic precipitation on ZIF-8/Bi2S3 photoelectrode: an aptasensing platform for sub-nanomolar kanamycin determination.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,      [PMID:] [10.1007/s00216-026-06418-0]