Determine the necessary mass, volume, or concentration for preparing a solution.
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≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature,Argon charged,Cool Ships Normal Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 23 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Usually used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides.
product description:
Molecular dynamics simulation study of the two known polymorphs of 4′-hydroxyacetophenone (form I, monoclinic; form II, orthorhombic) has been described.
application:
4′-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.
| Pubchem Sid | 488180448 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488180448 |
| Sonrisas canónicas | CC(=O)C1=CC=C(C=C1)O |
| IUPAC Name | 1-(4-hydroxyphenyl)ethanone |
| InChIKey | TXFPEBPIARQUIG-UHFFFAOYSA-N |
| INCHI | 1S/C8H8O2/c1-6(9)7-2-4-8(10)5-3-7/h2-5,10H,1H3 |
| Isómeros SMILES | CC(=O)C1=CC=C(C=C1)O |
| WGK Alemania | 3 |
| RTECS | AM8750000 |
| Peso molecular | 136.15 |
| Beilstein | 774355 |
| Reaxy-Rn | 774355 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=774355&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic oxygen compounds |
| Clase | Organooxygen compounds |
| Subclass | Carbonyl compounds |
| Intermediate Tree Nodes | Ketones - Aryl ketones - Phenylketones |
| Direct Parent | Alkyl-phenylketones |
| Alternative Parents | Acetophenones Benzoyl derivatives Aryl alkyl ketones 1-hydroxy-2-unsubstituted benzenoids Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Alkyl-phenylketone - Acetophenone - Aryl alkyl ketone - Benzoyl - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Benzenoid - Monocyclic benzene moiety - Organic oxide - Hydrocarbon derivative - Aromatic homomonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as alkyl-phenylketones. These are aromatic compounds containing a ketone substituted by one alkyl group, and a phenyl group. |
| External Descriptors | an aromatic compound - a methyl-ethyl-ketone |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
| Certificate of Analysis | May 19, 2026 | H102969 | |
| Certificate of Analysis | Feb 05, 2026 | H102969 | |
| Certificate of Analysis | Feb 05, 2026 | H102969 | |
| Certificate of Analysis | Feb 05, 2026 | H102969 | |
| Certificate of Analysis | Mar 28, 2025 | H102969 | |
| Certificate of Analysis | Mar 28, 2025 | H102969 | |
| Certificate of Analysis | Mar 28, 2025 | H102969 | |
| Certificate of Analysis | Jul 10, 2024 | H102969 | |
| Certificate of Analysis | Jul 10, 2024 | H102969 | |
| Certificate of Analysis | Jul 10, 2024 | H102969 | |
| Certificate of Analysis | Jul 10, 2024 | H102969 | |
| Certificate of Analysis | Sep 06, 2022 | H102969 | |
| Certificate of Analysis | Sep 06, 2022 | H102969 | |
| Certificate of Analysis | Sep 06, 2022 | H102969 | |
| Certificate of Analysis | Sep 06, 2022 | H102969 | |
| Certificate of Analysis | Sep 06, 2022 | H102969 | |
| Certificate of Analysis | Sep 06, 2022 | H102969 | |
| Certificate of Analysis | Sep 06, 2022 | H102969 | |
| Certificate of Analysis | Sep 06, 2022 | H102969 | |
| Certificate of Analysis | Sep 06, 2022 | H102969 | |
| Certificate of Analysis | Sep 06, 2022 | H102969 | |
| Certificate of Analysis | Sep 06, 2022 | H102969 | |
| Certificate of Analysis | Sep 06, 2022 | H102969 | |
| Certificate of Analysis | Jun 29, 2022 | H102969 | |
| Certificate of Analysis | Jun 29, 2022 | H102969 | |
| Certificate of Analysis | Jun 29, 2022 | H102969 | |
| Certificate of Analysis | Jun 29, 2022 | H102969 |
| Solubilidad | Soluble in 95% Ethanol. Slightly soluble in water. |
|---|---|
| Sensibilidad | Hygroscopic |
| Punto de inflamación (°F) | 330°F |
| Punto de inflamación (°C) | 166℃ |
| Punto de ebullición (°C) | 147-148°C |
| Punto de fusión (°C) | 109-111°C |
| Peso molecular | 136.150 g/mol |
| XLogP3 | 1.400 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 1 |
| Exact Mass | 136.052 Da |
| Monoisotopic Mass | 136.052 Da |
| Topological Polar Surface Area | 37.300 Ų |
| Heavy Atom Count | 10 |
| Formal Charge | 0 |
| Complexity | 123.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Daihong Gao, Denghao Ouyang, Xuebing Zhao. (2023) Controllable oxidative depolymerization of lignin to produce aromatic aldehydes and generate electricity under mild conditions with direct biomass fuel cells as flexible reactors. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2023.147874] |
| 2. Tong Shao, Xiaolei Song, Yufeng Jiang, Chenchen Wang, Peng Li, Shihao Sun, Dingzhong Wang, Wei Wei. (2023) Vanillin-Catalyzed highly sensitive luminol chemiluminescence and its application in food detection. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:36857865] [10.1016/j.saa.2023.122535] |
| 3. Mingxue Li, Pijun Duan, Yanru Huo, Jinchan Jiang, Yuxin Zhou, Yuhui Ma, Zhehui Jin, Qiong Mei, Ju Xie, Maoxia He. (2022) The multiple roles of phenols in the degradation of aniline contaminants by sulfate radicals: A combined study of DFT calculations and experiments. JOURNAL OF HAZARDOUS MATERIALS, [PMID:36334575] [10.1016/j.jhazmat.2022.130216] |
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| 6. Jing Chen, Hanling Yang, Hongquan Fu, Hongyan He, Qiang Zeng, Xuehui Li. (2020) Electrochemical oxidation mechanisms for selective products due to C–O and C–C cleavages of β-O-4 linkages in lignin model compounds. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 22 (20): (11508-11518). [PMID:32393942] [10.1039/D0CP01091J] |
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| 11. ChenDi Ding, Ying Liu, MingDong Wang, Ting Wang, JiaJun Fu. (2016) Self-healing, superhydrophobic coating based on mechanized silica nanoparticles for reliable protection of magnesium alloys. Journal of Materials Chemistry A, 4 (21): (8041-8052). [PMID:] [10.1039/C6TA02575G] |
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| 14. Zhixuan Zhou, Jiaru Zhuo, Sujun Yan, Lin Ma. (2013) Design and synthesis of 3,5-diaryl-4,5-dihydro-1H-pyrazoles as new tyrosinase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, [PMID:23391365] [10.1016/j.bmc.2012.12.054] |
| 15. Liting Xu, Fengyun Shi, Jinghua Zhao, Limin Wu, Hongkun Li, Yi Li, Wei Liu, Yonggang Yang. (2024) Circularly Polarized Luminescence of Cholesteric Liquid Crystal Polymer Networks with a Europium(III) Complex as an Emitter. ACS Applied Materials & Interfaces, [PMID:38485216] [10.1021/acsami.3c18353] |
| 16. Zhao Song, Yu Zhang, Peiru He, Xuesong Liu, Nanqi Ren, Yidi Chen. (2024) Feasibility of phenolic contaminant removal from high-saline wastewater by chloride-mediated activation of peroxymonosulfate (PMS) and peracetic acid (PAA). SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2024.126856] |
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| 20. Yifan Zhang, Jiaying Liu, Shiwei Wang, Zhihao Yu, Haojian Zhang, Dong Wang, Lin Zhu, Chunzheng Wu, Hongbo Yu. (2025) Enhanced Selective Hydrogenation of Acetophenone over KIT-6 Supported Pd-MO x (M = Fe, Co, Ni) Hybrid Nanostructures. Catalysis Science & Technology, [PMID:] [10.1039/D5CY01108F] |
| 21. Pengfei Lian, Zengji Yao, Guangwei Sun, Yao Li, Zihao Ma, Xing Wang, Ying Han. (2025) Continuous Synthesis of Quinolines Derivatives from Catalytic Oxidative depolymerization Products of Lignin in a Micro-manufacturing Platform. JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS, [PMID:] [10.1016/j.jaap.2025.107579] |
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