Determine the necessary mass, volume, or concentration for preparing a solution.
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≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature Ships Normal Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 11 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Product Application:
4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.
| Pubchem Sid | 488202850 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488202850 |
| Sonrisas canónicas | C1=CC=C2C(=C1)C(=O)NC=N2 |
| IUPAC Name | 3H-quinazolin-4-one |
| InChIKey | QMNUDYFKZYBWQX-UHFFFAOYSA-N |
| INCHI | 1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11) |
| Isómeros SMILES | C1=CC=C2C(=C1)C(=O)NC=N2 |
| WGK Alemania | 3 |
| RTECS | VA2300000 |
| Peso molecular | 146.15 |
| Beilstein | 24143 |
| Reaxy-Rn | 118473 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=118473&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Clase | Diazanaphthalenes |
| Subclass | Benzodiazines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Quinazolines |
| Alternative Parents | Hydroxypyrimidines Benzenoids Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Quinazoline - Hydroxypyrimidine - Benzenoid - Pyrimidine - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as quinazolines. These are compounds containing a quinazoline moiety, which is made up of two fused six-member aromatic rings, a benzene ring and a pyrimidine ring. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
| Certificate of Analysis | Mar 11, 2026 | H157172 | |
| Certificate of Analysis | Mar 11, 2026 | H157172 | |
| Certificate of Analysis | Mar 11, 2026 | H157172 | |
| Certificate of Analysis | Mar 11, 2026 | H157172 | |
| Certificate of Analysis | Mar 11, 2026 | H157172 | |
| Certificate of Analysis | Mar 11, 2026 | H157172 | |
| Certificate of Analysis | Mar 11, 2026 | H157172 | |
| Certificate of Analysis | Mar 11, 2026 | H157172 | |
| Certificate of Analysis | Apr 17, 2024 | H157172 | |
| Certificate of Analysis | Oct 20, 2022 | H157172 |
| Solubilidad | Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM). |
|---|---|
| Sensibilidad | Hygroscopic |
| Punto de fusión (°C) | 215.0 ~220.0 °C |
| Peso molecular | 146.150 g/mol |
| XLogP3 | 0.700 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 0 |
| Exact Mass | 146.048 Da |
| Monoisotopic Mass | 146.048 Da |
| Topological Polar Surface Area | 41.500 Ų |
| Heavy Atom Count | 11 |
| Formal Charge | 0 |
| Complexity | 200.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Tang Hongjie, Liu Yingzhu, Xu Haotian, Wang Fenghui, Xie Cancan, Zhang Huajiang, Jiang Longwei. (2023) Preparation and Characterization of Quercetin/Cyclodextrin/Carbon Quantum Dot Nanocomplexes and Evaluation of their Stability and In Vitro Digestive Properties. Food Biophysics, [PMID:] [10.1007/s11483-023-09821-7] |
| 2. Hanxun Yue, Xuan Zhao, Qin Yong, Min Shi, Xiaofeng Jiang, Yating Zhang, Xian Yu. (2023) Self-assembly of Hyaluronic Acid-Cu-Quercetin flavonoid nanoparticles: synergistic chemotherapy to target tumors. PeerJ, [PMID:37663303] [10.7717/peerj.15942] |
| 3. Zhiqi Zhai, Yue Fu, Xinyue Zhang, Yi Zhang, Chao Zhou, Xiaojia Huang, Linhong Deng. (2023) Liposomes loaded with quercetin for resolution of lung inflammation in a lipopolysaccharide-induced mouse model of sepsis. Biomedical Materials, 18 (3): (035004). [PMID:36863020] [10.1088/1748-605X/acc0bc] |
| 4. Fangping Liang, Wurong Li, Mingao Li, Xican Li, Jianfeng He, Quanzhou Wu. (2023) Kaempferol molecularly imprinted polymers: preparation, characterization and application to the separation of kaempferol from ginkgo leaves. POLYMER INTERNATIONAL, 72 (6): (586-596). [PMID:] [10.1002/pi.6511] |
| 5. Ziqian Xu, Yihui Xie, Jun Song, Juntao Huang, Weimin Shi. (2022) Mechanism of Action of a Chinese Herbal Compound Containing Quercetin, Luteolin, and Kaempferol in the Treatment of Vitiligo Based on Network Pharmacology and Experimental Verification. Evidence-based Complementary and Alternative Medicine, [PMID:36569347] [10.1155/2022/7197533] |
| 6. Tian Rui, Wang Hui, Xiao Yi, Hu Pengyue, Du Ruofei, Shi Xiufeng, Wang Zhengtao, Xie Yan. (2020) Fabrication of Nanosuspensions to Improve the Oral Bioavailability of Total Flavones from Hippophae rhamnoides L. and their Comparison with an Inclusion Complex. AAPS PHARMSCITECH, 21 (7): (1-14). [PMID:32875458] [10.1208/s12249-020-01788-9] |
| 7. Qin Tang, Fangling Ji, Jingyun Wang, Lianying Guo, Yachen Li, Yongming Bao. (2017) Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:28822757] [10.1016/j.ejps.2017.08.013] |
| 8. Jing Li, Jun Zhang, Yiyue Wang, Xiao Liang, Zaitongguli Wusiman, Yunzhi Yin, Qi Shen. (2017) Synergistic inhibition of migration and invasion of breast cancer cells by dual docetaxel/quercetin-loaded nanoparticles via Akt/MMP-9 pathway. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:28336457] [10.1016/j.ijpharm.2017.03.040] |
| 9. Zhixian Liang, Haiyun Zhai, Zuanguang Chen, Shiqiao Wang, Haihang Wang, Shumei Wang. (2017) A sensitive electrochemical sensor for flavonoids based on a multi-walled carbon paste electrode modified by cetyltrimethyl ammonium bromide-carboxylic multi-walled carbon nanotubes. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2016.12.108] |
| 10. Xiaoyu Jia, Kaiting He, Ling Cai, Yuhui Liu, Henghui Li, Xiaoxiao Dong, Min He, Li Zhang, Guannan Le, Shoulin Wang, Jin Chen. (2025) Coaxially fabricated electrospinning near-infrared light-responsive nanofibrous membranes for combating drug-resistant bacteria. JOURNAL OF HAZARDOUS MATERIALS, [PMID:40199072] [10.1016/j.jhazmat.2025.138106] |
| 11. Haibo Liu, Zhongyi Sun, Mengting Yin, Jing Ru, Xiaohao Liu, Ziyan Chen, Yating Liu, Wang Sun, Longpo Zheng, Xinyu Zhao, Feng Chen. (2025) Polyphenol-Modified Mg−Zn Layered Hydroxide-Contained Microneedle Patch Enhance Mucosal Repair by Remolding Diabetic Oral Microenvironment. Advanced Healthcare Materials, [PMID:39930773] [10.1002/adhm.202403883] |