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4-Methyl-2-(1-piperidinyl)-quinoline - Moligand™, ≥98%(HPLC) , Channel blocker of TRPC4;Channel blocker of TRPC5, CAS No.5465-86-1, Channel blocker of TRPC4;Channel blocker of TRPC5

CAS: 5465-86-1 Cat. No.: M134489 Peso molecular: 226.32 Número EC: 803-730-5
1 Citations COA
4-Methyl-2-(1-piperidinyl)-quinoline - Moligand™, ≥98%(HPLC) CAS No(5465-86-1) by Aladdin Scientific
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
Synonyms
GTPL4255 | STL305647 | 4-Methyl-2-(1-piperidinyl)-quinoline;ML204 | A870393 | BDBM77617 | SCHEMBL14975993 | F17389 | 4-methyl-2-piperidin-1-ylquinoline | 4-methyl-2-piperidin-1-yl-quinoline | 4-methyl-2-piperidinoquinoline | 4-methyl-2-piperidino-quinolin
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
5mg
M134489-5mg
3

9,90US$

14,90US$
Guardar 5,00 US$ (33.56%)
25mg
M134489-25mg
3

33,90US$

50,90US$
Guardar 17,00 US$ (33.40%)
100mg
M134489-100mg
2

108,90US$

163,90US$
Guardar 55,00 US$ (33.56%)
Enter a quantity for the sizes you want to add.
Bulk / Custom
♡ Lista de deseos ⇅ Añadir para comparar ⎙ Print page
SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Specifications Nombres e identificadores Documentation Advanced Data Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Citations of This Product Referencias Calculadoras de soluciones Reseñas
🧪

Why this grade

Moligand™, ≥98%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Sinónimos
GTPL4255 | STL305647 | 4-Methyl-2-(1-piperidinyl)-quinoline;ML204 | A870393 | BDBM77617 | SCHEMBL14975993 | F17389 | 4-methyl-2-piperidin-1-ylquinoline | 4-methyl-2-piperidin-1-yl-quinoline | 4-methyl-2-piperidinoquinoline | 4-methyl-2-piperidino-quinolin
Especificaciones y pureza
Moligand™, ≥98%(HPLC)
Mecanismos bioquímicos y fisiológicos
Blocker of TRPC4 channels (IC50values are 0.96 and 2.6μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Tipo de acción
CHANNEL BLOCKER
Mecanismo de acción
Channel blocker of TRPC4;Channel blocker of TRPC5
Pureza
≥98%(HPLC)
Nombres e identificadores
Pubchem Sid504757991
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504757991
Sonrisas canónicasCC1=CC(=NC2=CC=CC=C12)N3CCCCC3
IUPAC Name4-methyl-2-piperidin-1-ylquinoline
InChIKeyUSYRQXDHKXGTCK-UHFFFAOYSA-N
INCHI1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3
Isómeros SMILES CC1=CC(=NC2=CC=CC=C12)N3CCCCC3
WGK Alemania 3
Peso molecular 226.32
Reaxy-Rn 476172
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=476172&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
TRPC4 Tchem Short transient receptor potential channel 4 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TRPC5 Tchem Short transient receptor potential channel 5 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMPD1 Tchem Sphingomyelin phosphodiesterase (13561 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L3MBTL1 Tchem Lethal(3)malignant brain tumor-like protein 1 (14536 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Luciferin 4-monooxygenase (66902 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trpc4 Short transient receptor potential channel 4 (1615 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trpc6 Short transient receptor potential channel 6 (57 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot NumberCertificate TypeFechaArticulo
G2215686Certificate of AnalysisJan 20, 2026 M134489
G2215687Certificate of AnalysisJan 20, 2026 M134489
G2215688Certificate of AnalysisJan 20, 2026 M134489
Propiedades químicas y físicas
SolubilidadSolvent:DMSO, Max Conc. mg/mL: 22.63, Max Conc. mM: 100; Solvent:1eq. HCl, Max Conc. mg/mL: 5.66, Max Conc. mM: 25 with gentle warming
Peso molecular226.320 g/mol
XLogP33.900
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass226.147 Da
Monoisotopic Mass226.147 Da
Topological Polar Surface Area16.100 Ų
Heavy Atom Count17
Formal Charge0
Complexity247.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
How to Cite Aladdin Scientific Products? Citations Search
Referencias
1. Liu Yang, Zeyu Peng, Fanpeng Gong, WenXin Yan, Yi Shi, Hanyi Li, Chang Zhou, Hong Yao, Menglu Yuan, Fan Yu, Lei Feng, Naifu Wan, Guizhu Liu.  (2024)  TRPC4 aggravates hypoxic pulmonary hypertension by promoting pulmonary endothelial cell apoptosis.  FREE RADICAL BIOLOGY AND MEDICINE,      [PMID:38636714] [10.1016/j.freeradbiomed.2024.04.224]
Calculadoras de soluciones
Reseñas

Reseñas de cliente

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