10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 49 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.
In vitro
In vivo
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isómeros SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)O |
|---|---|
| WGK Alemania | 2 |
| RTECS | GN7000000 |
| Peso molecular | 176.17 |
| Beilstein | 142217 |
| Reaxy-Rn | 142217 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=142217&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Punto de fusión (°C) | 188.5-190°C |
|---|
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| 2. Ning Li, Xiaoyu Zhang, Yuxi Zhang, Guorui Wang, Ruotong Wang, Chi Zhang, Fanglei Zeng, Hailong Liu, Gang Yi, Zhongwei Wang. (2023) Preparation of multi band photothermal responsive bio-based superhydrophobic self-healing poly(siloxane-urethane) coating. JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY, [PMID:] [10.1080/01694243.2023.2219360] |
| 3. Y. You, M.R. Fu, M.Z. Rong, M.Q. Zhang. (2021) Improving creep resistance while maintaining reversibility of covalent adaptive networks via constructing reversibly interlocked polymer networks. Materials Today Chemistry, [PMID:] [10.1016/j.mtchem.2021.100687] |
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| 5. Yu-Mei Zhao, Lv-Huan Wang, Si-Fan Luo, Qi-Qin Wang, Ruin Moaddel, Ting-Ting Zhang, Zheng-Jin Jiang. (2018) Magnetic beads-based neuraminidase enzyme microreactor as a drug discovery tool for screening inhibitors from compound libraries and fishing ligands from natural products. JOURNAL OF CHROMATOGRAPHY A, [PMID:30005943] [10.1016/j.chroma.2018.07.031] |
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| 7. Hua Sun, Xiaotong Zhou, Baojian Wu. (2015) Accurate identification of UDP-glucuronosyltransferase 1A1 (UGT1A1) inhibitors using UGT1A1-overexpressing HeLa cells. XENOBIOTICA, [PMID:26068529] [10.3109/00498254.2015.1033502] |
| 8. Yujie Liu, Xiaoyu Zhang, Xixian Yan, Chi Zhang, Ning Li, Fanglei Zeng, Shengling Jiang, Jianning Ding. (2024) Preparation and Properties of Multiple Dynamic Crosslinked Poly(siloxane-urethane). ChemistrySelect, 9 (29): (e202401934). [PMID:] [10.1002/slct.202401934] |
| 9. Chao Xing, Xiaoqiu Dou, Laiben Gao, Peng Xu, Yinbo Peng, Kaikai Yang, Yong Fang, Kai Hou, Shegan Gao, Chuanliang Feng. (2025) Chiral Artificial Antigen-Presenting Cells Enhancing Tumor Immunotherapy: Evasion of Macrophage Uptake through Inhibition of Serum Protein Corona Formation. ACS Nano, [PMID:40729751] [10.1021/acsnano.5c04444] |
| 10. Junnan Fang, Xiaojie Wang, Li Li, Juanjuan Liu, Ling Fang, Yazhong Xiao, Yan Wang, Zemin Fang. (2025) A sucrose transporter from Gongronella butleri w5 mediates plant-fungus-bacteria interaction. CURRENT BIOLOGY, [PMID:40961929] [10.1016/j.cub.2025.08.043] |
| 11. Heng Zhang, Yiping Yang, Shengchao Yang, Yuchang Qin, Xuan Lv, Lin Cui, Wei Jia, Zhiyong Liu. (2025) NIR Responsive Polymeric Prodrug Micelles ZnPc@P(PEG-CMA-TKGEM) for Combating Gemcitabine Drug Delivery in Anticancer Chemotherapy. Materials, 18 (17): (4165). [PMID:40942591] [10.3390/ma18174165] |
| 12. Huiqiang Yang, Na Chen, Zhiqiang Wang, Jinbo Liu, Jianjun Qin, Kecheng Zhu, Hanzhong Jia. (2023) Biochar-Associated Free Radicals Reduce Soil Bacterial Diversity: New Insight into Ecoenzymatic Stoichiometry. ENVIRONMENTAL SCIENCE & TECHNOLOGY, [PMID:37976412] [10.1021/acs.est.3c06864] |
| 13. Chao Xing, Laiben Gao, Xiaoqiu Dou, Kaikai Yang, Changli Zhao, Chuanliang Feng. (2023) Supramolecular Chiral Nanofibers Activated Pro-Survival Autophagy: An Extracellular Strategy for Hypoxic Cell Protection. ADVANCED FUNCTIONAL MATERIALS, [PMID:] [10.1002/adfm.202310426] |
| 14. Siyu Yang, Qiuyan Luo, Chuanluan Guo, Jia Jiang, Xiaohong Wang, Juguo Dai, Dongxu Li, Kaibin He, Yiting Xu, Conghui Yuan, Weiang Luo, Lizong Dai. (2023) Multifunctional Organohydrogels for pH-Responsive Fluorescent and Electrostimulus Writing. ACS Applied Materials & Interfaces, [PMID:37878837] [10.1021/acsami.3c12497] |
| 15. Chunling Ren, Xiao Xu, Dan Yan, Mengzhen Gu, Jinghan Zhang, Haili Zhang, Chao Han, Lingyi Kong. (2022) Dual-action nanoplatform with a synergetic strategy to promote oxygen accumulation for enhanced photodynamic therapy against hypoxic tumors. Acta Biomaterialia, [PMID:35526738] [10.1016/j.actbio.2022.04.035] |
| 16. Yi Zhang, Cai Li, Qin Sun, Cuiling Jiang, Shiming Ding, Musong Chen, Xin Ma, Zhilin Zhong, Yan Wang, Daniel C.W. Tsang. (2021) Phosphorus acquisition strategy of Vallisneria natans in sediment based on in situ imaging techniques. ENVIRONMENTAL RESEARCH, [PMID:34242674] [10.1016/j.envres.2021.111635] |
| 17. Yaxin Qiu, Dheeman-Roy Munna, Fang Wang, Juqun Xi, Zhifeng Wang, Defeng Wu. (2021) Regulating Asynchronous Deformations of Biopolyester Elastomers via Photoprogramming and Strain-Induced Crystallization. MACROMOLECULES, [PMID:] [10.1021/acs.macromol.1c00758] |
| 18. Yuye Zhu, Min Chen, Limin Wu. (2021) Synthesis of UV-Responsive Dual-Functional Microspheres for Highly Efficient Self-Healing Coatings. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2021.130034] |
| 19. Chen Xu, Jinhui Lu, Li Zhou, Jie Liang, Lei Fang, Feng Cao. (2021) Multifunctional nanocomposite eye drops of cyclodextrin complex@layered double hydroxides for relay drug delivery to the posterior segment of the eye. CARBOHYDRATE POLYMERS, [PMID:33712148] [10.1016/j.carbpol.2021.117800] |
| 20. Yu-Xi Feng, Xin Chen, Yan-Wen Li, Hai-Ming Zhao, Lei Xiang, Hui Li, Quan-Ying Cai, Nai-Xian Feng, Ce-Hui Mo, Ming-Hung Wong. (2020) A Visual Leaf Zymography Technique for the In Situ Examination of Plant Enzyme Activity under the Stress of Environmental Pollution. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:32822176] [10.1021/acs.jafc.0c03815] |
| 21. Jinbo Ouyang, Jian Chen, Haiqing Huang, Limin Zhou, Xin Huang. (2020) Solid-liquid equilibrium and dissolution thermodynamics of 4-Methylumbelliferon in different solvents. JOURNAL OF MOLECULAR LIQUIDS, [PMID:] [10.1016/j.molliq.2020.112797] |
| 22. De-Yang Li, Da-Yong Zhou, Fa-Wen Yin, Xiu-Ping Dong, Hong-Kai Xie, Zhong-Yuan Liu, Ao Li, Jia-Xuan Li, Kanyasiri Rakariyatham, Fereidoon Shahidi. (2020) Impact of different drying processes on the lipid deterioration and color characteristics of Penaeus vannamei. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 100 (6): (2544-2553). [PMID:32017121] [10.1002/jsfa.10280] |
| 23. Dan Chen, Ya-Xian Wu, Yu-bao Qiu, Bin-bin Wan, Gang Liu, Jun-liang Chen, Mu-dan Lu, Qing-feng Pang. (2019) Hyperoside suppresses hypoxia-induced A549 survival and proliferation through ferrous accumulation via AMPK/HO-1 axis. PHYTOMEDICINE, [PMID:31881478] [10.1016/j.phymed.2019.153138] |
| 24. Hongkai Xie, Dayong Zhou, Xiaopei Hu, Zhongyuan Liu, Liang Song, Beiwei Zhu. (2018) Changes in Lipid Profiles of Dried Clams (Mactra chinensis Philippi and Ruditapes philippinarum) during Accelerated Storage and Prediction of Shelf Life. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:29965751] [10.1021/acs.jafc.8b03047] |
| 25. Bo Wu, Guangming Liu, Guangzhao Zhang, Vincent S. J. Craig. (2018) Polyelectrolyte multilayers under compression: concurrent osmotic stress and colloidal probe atomic force microscopy. Soft Matter, 14 (6): (961-968). [PMID:29322154] [10.1039/C7SM02177A] |
| 26. Xiaoyun Liu, Ruhong Zhang, Tianquan Li, Pengfei Zhu, Qixin Zhuang. (2017) Novel Fully Biobased Benzoxazines from Rosin: Synthesis and Properties. ACS Sustainable Chemistry & Engineering, [PMID:] [10.1021/acssuschemeng.7b02650] |
| 27. Shasha Jing, Huijun Zheng, Li Zhao, Lingbo Qu, Lanlan Yu. (2017) A sensitive sodium dodecyl sulfonate functionalized graphene hybrid SnO2 nanoparticles composite modified glassy carbon electrode for detecting daphnetin. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, [PMID:] [10.1016/j.jelechem.2017.01.027] |
| 28. Lanfang Pang, Yanmei Zhou, Wenli Gao, Haohan Song, Xiao Wang, Yong Wang. (2016) A highly selective and sensitive fluorescence probe for rapid detection of hypochlorite in tap water and cancer cells. RSC Advances, 6 (107): (105795-105800). [PMID:] [10.1039/C6RA23548D] |
| 29. Yanfen Bai, Hua Yin, Huiping Bi, Yibin Zhuang, Tao Liu, Yanhe Ma. (2016) De novo biosynthesis of Gastrodin in Escherichia coli. METABOLIC ENGINEERING, [PMID:26804288] [10.1016/j.ymben.2016.01.002] |
| 30. Liang Zeng, Jingna Yan, Liyong Luo, Dongying Zhang. (2015) Effects of Pu-erh tea aqueous extract (PTAE) on blood lipid metabolism enzymes. Food & Function, 6 (6): (2008-2016). [PMID:26018873] [10.1039/C5FO00362H] |
| 31. Jianbin Zhang, Yan Lv, Bing Wang, Shan Zhao, Mingqian Tan, Guojun Lv, Xiaojun Ma. (2015) Influence of Microemulsion–Mucin Interaction on the Fate of Microemulsions Diffusing through Pig Gastric Mucin Solutions. MOLECULAR PHARMACEUTICS, [PMID:25608210] [10.1021/mp500475y] |
| 32. Chang Huan, Liu Yan, Shi Mei, Liu Zhaotie, Liu Zhongwen, Jiang Jinqiang. (2014) Photo-induced dynamic association of coumarin pendants within amphiphilic random copolymer micelles. COLLOID AND POLYMER SCIENCE, 293 (3): (823-831). [PMID:] [10.1007/s00396-014-3474-7] |
| 33. Hongfei Leng, Qingyuan Niu, Wenhui Wu. (2012) Insoluble porous conjugated polymer films via phase separation and photo-crosslinking for the trace detection of 2,4-dinitrotoluene. POLYMER INTERNATIONAL, 62 (8): (1187-1191). [PMID:] [10.1002/pi.4405] |
| 34. Lijun Wang, Zhe Wang, Hua Zhang, Qian Jin, Shuaihua Fan, Yanni Liu, Xueting Huang, Jun Guo, Chao Cai, Jing-ren Zhang, Hui Wu. (2024) A novel esterase regulates Klebsiella pneumoniae hypermucoviscosity and virulence. PLoS Pathogens, 20 (10): (e1012675). [PMID:39480904] [10.1371/journal.ppat.1012675] |
| 35. Zhen Wu, Jinlong Wang, Xing Cheng, Yue Tang, Lian Xia, Xiaojuan Niu, Yuangen Wu. (2025) A novel fluorescent sensor for highly sensitive detection of ascorbic acid in food based on inhibiting phosphatase-like activity of Zr-based MOF. FOOD CHEMISTRY, [PMID:39808980] [10.1016/j.foodchem.2025.142837] |
| 36. Hong Yang, Yan Bao, Chao Liu, Sike Yu, Ruyue Guo, Wenbo Zhang, Ji Li. (2025) Innovative UV-Responsive Self-Healing Polyacrylate Coatings for Enhanced Durability in Functional Applications. JOURNAL OF APPLIED POLYMER SCIENCE, [PMID:] [10.1002/app.56962] |
| 37. Jian Wang, Maoan Wang, Shuwen Xu, Fenglei Zhang. (2024) Preparation and Performance Study of Ultraviolet-Responsive Self-Healing Epoxy Asphalt. Materials, 17 (17): (4403). [PMID:39274792] [10.3390/ma17174403] |
| 38. Ming Liu, Qianwen Wang, Bin Lai, Yan Chen, Rongchumu Ge, Shuo Yan, Chunya Bu. (2024) RNA interference targeting β-N-acetylhexosaminidase genes impairs molting and development of Tetranychus urticae. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, [PMID:40015851] [10.1016/j.pestbp.2024.106259] |
| 39. Qiuyan Luo, Jia Jiang, Juguo Dai, Dongxu Li, Hanzhong Ren, Hucheng Fu, Aihua Tang, Yiting Xu, Birong Zeng, Weiang Luo, Lizong Dai. (2025) Programmable metal ion-induced patterned multicolour carboxymethylcellulose-based fluorescent hydrogels for information encoding and encryption. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:40659273] [10.1016/j.ijbiomac.2025.145897] |
| 40. Shuai Zhou, Chendi Ding, Cheng Wang, Jiajun Fu. (2019) UV-light cross-linked and pH de-cross-linked coumarin-decorated cationic copolymer grafted mesoporous silica nanoparticles for drug and gene co-delivery in vitro. Materials Science & Engineering C-Materials for Biological Applications, [PMID:31923958] [10.1016/j.msec.2019.110469] |
| 41. Zhang Jianbin, Lv Yan, Zhao Shan, Wang Bing, Tan Mingqian, Xie Hongguo, Lv Guojun, Ma Xiaojun. (2014) Effect of Lipolysis on Drug Release from Self-microemulsifying Drug Delivery Systems (SMEDDS) with Different Core/Shell Drug Location. AAPS PHARMSCITECH, 15 (3): (731-740). [PMID:24554238] [10.1208/s12249-014-0096-9] |
| 42. Meijie Wang, Kaiwei He, Jilu Li, Tong Shen, Yang Li, Yiting Xu, Conghui Yuan, Lizong Dai. (2020) Dual pH-responsive charge-reversal and photo-crosslinkable polymer nanoparticles for controlled drug release. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, [PMID:32009554] [10.1080/09205063.2020.1725279] |
| 43. Yun-song Zhou, Yang Sheng, Peng Zhang, Rong Zhang, Mark Bradley, Yi-xin Sun. (2025) Ordered co-assembly based on chiral phenylalanine derivatives and achiral coumarin derivatives. Soft Matter, [PMID:40231479] [10.1039/D5SM00100E] |
| 44. Yaxin Qiu, Jinxuan Ai, Aiying Liu, Chengkai Yang, Zhifeng Wang, Chong Chen, Xiaozhi Wang. (2025) Dual-patterned programming of photoactive dynamically cross-linked polyester enabling customizable shape-shifting pathways. POLYMER, [PMID:] [10.1016/j.polymer.2025.128538] |
| 45. Ning Li, Wenjing Meng, Lin Chang, Zhaolei Qu, Bing Liu, Kang Liu, Yuemei Zhang, Lin Huang, Hui Sun. (2025) Interspecific collaboration enhances the litter nutrient cycling and fungal network connectivity in mixed forests. INDUSTRIAL CROPS AND PRODUCTS, [PMID:] [10.1016/j.indcrop.2025.121005] |
| 46. Liu Yujie, Wu Xinheng, Zhang Hao, Tan Changle, Sha Xiang, Miao Lifeng, Xue Yabo, Li Ning. (2025) Self-healing poly(siloxane-urethane) carbon nanotube composites with multi-band repairing capability and efficient recovery have significant photothermal response. COLLOID AND POLYMER SCIENCE, [PMID:] [10.1007/s00396-025-05450-3] |
| 47. Zhu Tao, Yi Zheng, Xiaodi Jin, Xin Zhang, Xie He, Haitao Liu, Chunhua Fu, Longjiang Yu. (2025) Construction and application of machine learning models to screen functional ingredients for alcohol metabolism and its mechanism research. Food Bioscience, [PMID:] [10.1016/j.fbio.2025.107685] |
| 48. Lei Chen, Yin Lu, Kan Zhang. (2025) Bio-based dicoumarin-containing benzoxazine resin: Synthesis, photo-thermal polymerization and thermal stability. REACTIVE & FUNCTIONAL POLYMERS, [PMID:] [10.1016/j.reactfunctpolym.2025.106396] |
| 49. Jianting Huang, Panyu Duan, Xincheng Dai, Jingcheng Zhang, Wei Yue, Yafeng Li, Longyuan Guo, Mingdeng Wei. (2026) Ultraviolet Absorbers Stabilize the Self-Assembled Monolayers and Passivate the Buried Interface for Highly Efficient and Stable Inverted Perovskite Solar Cells. ADVANCED FUNCTIONAL MATERIALS, [PMID:] [10.1002/adfm.74817] |
