5-(6)-CDCF [5(6)-Carboxy-2',7'-dichlorofluorescein] - for fluorescence analysis, ≥95% , CAS No.111843-78-8

CAS: 111843-78-8 Cat. No.: C131044 Peso molecular: 445.206 Número EC: 635-152-2

GRADE & PURITY for Fluorescence analysis, ≥95%

Synonyms

DTXSID20920579 | 5/'-carboxyl-2/',7/'-dichlorodihydrofluorescein | 5(6)-CARBOXY-2/' 7/'-DICHLOROFLUORESCEIN | CDCF | 2',7'-Dichloro-3',6'-dihydroxy-3-oxo-3H-spiro[isobenzo[b]furan-1,9'-xanthene]-5-carboxylic acid | CHEBI:59677 | Spiro(isobenzofuran-1(3H),

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

luorescent intracellular pH indicator in the pH 4-5 range;

5(6)-Carboxy-2′,7′-dichlorofluorescein may be used as a specific substrate/probe to study the identity, activity and specificity of multidrug resistance protein 2 (MRP2) molecules.

Specifications

Sinónimos

DTXSID20920579 | 5/'-carboxyl-2/', 7/'-dichlorodihydrofluorescein | 5(6)-CARBOXY-2/' 7/'-DICHLOROFLUORESCEIN | CDCF | 2', 7'-Dichloro-3', 6'-dihydroxy-3-oxo-3H-spiro[isobenzo[b]furan-1, 9'-xanthene]-5-carboxylic acid | CHEBI:59677 | Spiro(isobenzofuran-1(3H),

Especificaciones y pureza

for fluorescence analysis, ≥95%

Mecanismos bioquímicos y fisiológicos

Amine-reactive, green fluorophore. Intracellular pH indicator in the pH 4-5 range. DFCA DA precursor. 2, 7-Dichlorofluorescein derivative.

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

for Fluorescence analysis

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥95%

Nombres e identificadores

• Pubchem Sid: 504757014
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504757014
• Sonrisas canónicas: C1=CC2=C(C=C1C(=O)O)C(=O)OC23C4=CC(=C(C=C4OC5=CC(=C(C=C35)Cl)O)O)Cl
• IUPAC Name: 2',7'-dichloro-3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid
• InChIKey: JGZVUTYDEVUNMK-UHFFFAOYSA-N
• INCHI: 1S/C21H10Cl2O7/c22-13-4-11-17(6-15(13)24)29-18-7-16(25)14(23)5-12(18)21(11)10-2-1-8(19(26)27)3-9(10)20(28)30-21/h1-7,24-25H,(H,26,27)
• Isómeros SMILES: C1=CC2=C(C=C1C(=O)O)C(=O)OC23C4=CC(=C(C=C4OC5=CC(=C(C=C35)Cl)O)O)Cl
• WGK Alemania: 3
• Peso molecular: 445.206
• Reaxy-Rn: 24567250
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24567250&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Benzopyrans
      • Subclass 1-benzopyrans
        • Level5 Dibenzopyrans
          • Level6 Xanthenes

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Benzopyrans
• Subclass: 1-benzopyrans
• Intermediate Tree Nodes: Dibenzopyrans
• Direct Parent: Xanthenes
• Alternative Parents: M-phthalic acid and derivatives Diarylethers Phthalides Benzofuranones Isobenzofurans 1-hydroxy-2-unsubstituted benzenoids Dicarboxylic acids and derivatives Aryl chlorides Lactones Carboxylic acid esters Oxacyclic compounds Carboxylic acids Organochlorides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Xanthene - Meta_phthalic_acid - Diaryl ether - Phthalide - Benzofuranone - Isobenzofuranone - Isobenzofuran - Isocoumaran - 1-hydroxy-2-unsubstituted benzenoid - Dicarboxylic acid or derivatives - Benzenoid - Aryl chloride - Aryl halide - Carboxylic acid ester - Lactone - Oxacycle - Carboxylic acid derivative - Carboxylic acid - Ether - Organic oxygen compound - Organohalogen compound - Organochloride - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene rings joined to each other by a pyran ring.
• External Descriptors: oxaspiro compound

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: DMF: soluble; DMSO: soluble
• Sensibilidad: light sensitive
• Punto de fusión (°C): ≥250 °C
• Peso molecular: 445.200 g/mol
• XLogP3: 4.200
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 1
• Exact Mass: 443.98 Da
• Monoisotopic Mass: 443.98 Da
• Topological Polar Surface Area: 113.000 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 702.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1