5-HT7R antagonist 2 , CAS No.1448808-50-1

CAS: 1448808-50-1 Cat. No.: H1428573 Peso molecular: 252.31

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Descripción general

5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a K i of 67 nM, the IC 50 values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment. Pharmacokinetic Analysis ICR Male Mice 药代动力学分析 Plasma Intravenous Administration Intraperitoneal Administration T max (h) 0.08 0.25 T 1/2 (h) 0.77 1.06 C max (ng/mL) 33.07 156.44 AUC last (ng·h/mL) 28.31 143.27 CL (L/h/kg) 41.61 - V ss (L/kg) 32.43 - MRT (h) 0.79 0.93 F (%) 50.60

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Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

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Tipo de acción

ANTAGONIST

Nombres e identificadores

• Peso molecular: 252.31