5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM) - 10mM in DMSO , CAS No.207679-81-0

CAS: 207679-81-0 Cat. No.: H407829 Peso molecular: 341.49 Número EC: 801-894-2

GRADE & PURITY 10mM in DMSO

Synonyms

Desfesoterodine | (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

5-hydroxymethyl tolterodine (PNU 200577) is a newmuscarinic receptorantagonist with Kbof 0.84 nM.
In vitro

5-hydroxymethyl tolterodine is a major pharmacologically active metabolite of tolterodine. 5-hydroxymethyl tolterodine produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips. 5-hydroxymethyl tolterodine antagotizes muscarinic receptors with a pA₂ of 9.1. 5-hydroxymethyl tolterodine causes a concentration-dependent inhibition of (-)³ H-QNB binding in homogenates of guinea-pig urinary bladder, parotid gland, heart and cerebral cortex. 5-hydroxymethyl tolterodine has a similar pharmacological profile with tolterodine. Intravenous infusion of 5-hydroxymethyl tolterodine produces a dose-dependent inhibition of the intravesical volume-induced urinary bladder contraction measured as the micturition pressure.

In vivo

5-hydroxymethyl tolterodine is significantly more potent at inhibiting acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50 15 and 40 nmol/kg, respectively. 5-hydroxymethyl tolterodine is three times more potent at the urinary bladder compared to the salivary gland.
Cell Data

cell lines：SUDHL4, SUDHL6, Jurkat, MOLT4, and HL60

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Desfesoterodine | (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with K_b of 0.84 nM.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

ANTAGONIST

Nombres e identificadores

• Isómeros SMILES: CC(C)N(CC[C@H](C1=CC=CC=C1)C2=C(C=CC(=C2)CO)O)C(C)C
• Peso molecular: 341.49
• Reaxy-Rn: 13260616
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13260616&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 5 mg/mL (16.81 mM); Water: Insoluble; Ethanol: Insoluble