6-Thioguanine - γ-irradiated, BioReagent, suitable for hybridoma, 50 ×, lyophilized powder , CAS No.154-42-7

CAS: 154-42-7 Cat. No.: T755603 Peso molecular: 167.19 Beilstein Registry Number: 157765 Número EC: 205-827-2

GRADE & PURITY BioReagent, Suitable for hybridoma, γ-irradiated, 50 ×, lyophilized powder

Storage

Room temperature

Shipped In

Normal

Descripción general

Used in hybridoma formation applications as a selection agent.

Specifications

Especificaciones y pureza

γ-irradiated, BioReagent, suitable for hybridoma, 50 ×, lyophilized powder

Mecanismos bioquímicos y fisiológicos

Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.

Condiciones de almacenamiento de almacenamiento

Room temperature

Enviado en

Normal

Grado

BioReagent, Suitable for hybridoma, γ-irradiated

Propiedades del producto

• ALogP: -0.1

Nombres e identificadores

• Sonrisas canónicas: C1=NC2=C(N1)C(=S)N=C(N2)N
• IUPAC Name: 2-amino-3,7-dihydropurine-6-thione
• InChIKey: WYWHKKSPHMUBEB-UHFFFAOYSA-N
• INCHI: 1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)
• Isómeros SMILES: C1=NC2=C(N1)C(=S)N=C(N2)N
• WGK Alemania: 3
• RTECS: UP0740000
• Número ONU: 2811
• Grupo de embalaje: I
• Peso molecular: 167.19
• Beilstein: 157765
• Reaxy-Rn: 9390519
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9390519&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Imidazopyrimidines
      • Subclass Purines and purine derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Imidazopyrimidines
• Subclass: Purines and purine derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Purinethiones
• Alternative Parents: Pyrimidinethiones Aminopyrimidines and derivatives Imidazoles Heteroaromatic compounds Azacyclic compounds Primary amines Organosulfur compounds Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Purinethione - Aminopyrimidine - Pyrimidinethione - Pyrimidine - Azole - Imidazole - Heteroaromatic compound - Azacycle - Organopnictogen compound - Primary amine - Organosulfur compound - Organonitrogen compound - Organic nitrogen compound - Amine - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as purinethiones. These are purines in which the purine moiety bears a thioketone.
• External Descriptors: 2-aminopurines

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: 1 M NaOH: 50 mg/mL, clear to slightly hazy
• Punto de fusión (°C): 360°C
• Peso molecular: 167.190 g/mol
• XLogP3: -0.100
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 167.027 Da
• Monoisotopic Mass: 167.027 Da
• Topological Polar Surface Area: 111.000 Ų
• Heavy Atom Count: 11
• Formal Charge: 0
• Complexity: 225.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

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