9(10H)-Acridanone - ≥98% , CAS No.578-95-0

CAS: 578-95-0 Cat. No.: A105216 Peso molecular: 195.22 Beilstein Registry Number: 7104 Número EC: 209-434-7

GRADE & PURITY ≥98%

Synonyms

9,10-dihydroacridin-9-one | 9-Acridinol | acridone | InChI=1/C13H9NO/c15-13-9-5-1-3-7-11(9)14-12-8-4-2-6-10(12)13/h1-8H,(H,14,15 | UNII-6BK306GUQA | Acridin-9-one | AKOS000119816 | HY-W007771 | 9(10H)acridone | 9-(10H)acridone | 9(10H)-Acridone | 9-Acrida

Storage

Room temperature

Shipped In

Normal

Descripción general

Acridone is useful in various pharmacological activities. Acridone acetic acid is one of the most important derivatives of acridone and is known as neovir, an antiviral drug. Some of acridone's derivatives may be potentially used as antimalarial drugs.
A scaffold for the antiviral agent acridone acetic acid.

Specifications

Sinónimos

9, 10-dihydroacridin-9-one | 9-Acridinol | acridone | InChI=1/C13H9NO/c15-13-9-5-1-3-7-11(9)14-12-8-4-2-6-10(12)13/h1-8H, (H, 14, 15 | UNII-6BK306GUQA | Acridin-9-one | AKOS000119816 | HY-W007771 | 9(10H)acridone | 9-(10H)acridone | 9(10H)-Acridone | 9-Acrida

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Room temperature

Enviado en

Normal

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 488179653
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488179653
• Sonrisas canónicas: C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3N2
• IUPAC Name: 10H-acridin-9-one
• InChIKey: FZEYVTFCMJSGMP-UHFFFAOYSA-N
• INCHI: 1S/C13H9NO/c15-13-9-5-1-3-7-11(9)14-12-8-4-2-6-10(12)13/h1-8H,(H,14,15)
• Isómeros SMILES: C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3N2
• WGK Alemania: 3
• RTECS: AR6976000
• Peso molecular: 195.22
• Beilstein: 7104
• Reaxy-Rn: 7104
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7104&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Quinolines and derivatives
      • Subclass Benzoquinolines
        • Level5 Acridines
          • Level6 Acridones

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Quinolines and derivatives
• Subclass: Benzoquinolines
• Intermediate Tree Nodes: Acridines
• Direct Parent: Acridones
• Alternative Parents: Hydroquinolones Hydroquinolines Pyridines and derivatives Benzenoids Vinylogous amides Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Acridone - Dihydroquinolone - Dihydroquinoline - Pyridine - Benzenoid - Heteroaromatic compound - Vinylogous amide - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as acridones. These are acridines containing a ketone group attached to the C9 carbon atom of the acridine moiety.
• External Descriptors: cyclic ketone - acridines

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

PTH1R Tclin Parathyroid hormone receptor (47172 Activities)

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GLA Tclin Alpha-galactosidase A (5444 Activities)

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GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)

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GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)

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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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ATM Tchem Serine-protein kinase ATM (4198 Activities)

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CCRF-CEM (65223 Activities)

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G-361 (890 Activities)

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SK-OV-3 (52876 Activities)

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U-937 (7138 Activities)

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CH1 (841 Activities)

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HaCaT (4069 Activities)

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A2780 (11979 Activities)

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HTT Tchem Huntingtin (19182 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

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SMN1 Tchem Survival motor neuron protein (34246 Activities)

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LMNA Tbio Prelamin-A/C (36751 Activities)

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)

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GMNN Tbio Geminin (128009 Activities)

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MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)

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ATXN2 Tbio Ataxin-2 (54410 Activities)

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TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)

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KPNB1 Tbio Importin subunit beta-1/Snurportin-1 (25097 Activities)

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HepG2-CD81 (19978 Activities)

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Objetivos asociados (no humanos)

Cruzipain (33337 Activities)

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Saccharomyces cerevisiae (19171 Activities)

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Plasmodium falciparum (966862 Activities)

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Plasmodium berghei (192651 Activities)

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L1210 (27553 Activities)

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Calf thymus DNA (4845 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

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Rorc Nuclear receptor ROR-gamma (89407 Activities)

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FTL Ferritin light chain (43324 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in DMF: 50 mg/ml Does not mix with water.
• Punto de fusión (°C): 361-362°C
• Peso molecular: 195.220 g/mol
• XLogP3: 3.000
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 195.068 Da
• Monoisotopic Mass: 195.068 Da
• Topological Polar Surface Area: 29.100 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 239.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Gao Yue, Tan Jiangkun, Lu Jiao, Sun Zhiwei, Li Zan, Ji Zhongyin, Zhang Shijuan, You Jinmao.  (2020)  A novel fluorescent labeling reagent, 2-(9-acridone)-ethyl chloroformate, and its application to the analysis of free amino acids in honey samples by HPLC with fluorescence detection and identification with online ESI-MS.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  412  (30): (8339-8350).  [PMID:33029671] [10.1007/s00216-020-02969-y]

2. Xiaoqing Song, Shiyue Zhang, Qian He, Wangjun Liu, Hongxin Gao, Zhonglin Luo, Biaobing Wang.  (2026)  Constructing dual-light-excited epoxy-based afterglow material with high-brightness and long-duration suitable for application in harsh environments.  POLYMER,      [PMID:] [10.1016/j.polymer.2026.129613]