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· · COA & SDS Disponible para cada producto · Same-day shipping on in-stock items A 77-01 - ≥98% , CAS No.607737-87-1
Synonyms
A 77-01 | A-77-01 | A77-01 | AKOS026750350 | DTXSID80440480 | E98766 | NCGC00379015-02 | BCP13726 | EX-A2200 | MS-24090 | C18H14N4 | SCHEMBL17559240 | 4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quinoline | 4-[3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]qu
Shipped In
Hielera + almohadillas de hielo
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Why this grade ≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Conservar a -20°C Ships Hielera + almohadillas de hielo Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Sinónimos
A 77-01 | A-77-01 | A77-01 | AKOS026750350 | DTXSID80440480 | E98766 | NCGC00379015-02 | BCP13726 | EX-A2200 | MS-24090 | C18H14N4 | SCHEMBL17559240 | 4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quinoline | 4-[3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]qu
Especificaciones y pureza
≥98%
Mecanismos bioquímicos y fisiológicos
Potente inhibidor de TGF-βRI (ALK-5) (IC50= 34 nM). Inhibe la activación transcripcional del TGF-β. Inhibe la proliferación de células epiteliales pulmonares inducida por TGF-β y la fosforilación de SMAD. Inhibe la transición epitelio-mesénquima (EMT) ind
Condiciones de almacenamiento de almacenamiento
Conservar a -20°C
Enviado en
Hielera + almohadillas de hielo
Nombres e identificadores Sonrisas canónicas CC1=NC(=CC=C1)C2=C(C=NN2)C3=CC=NC4=CC=CC=C34 IUPAC Name 4-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline InChIKey KJTYZDORHCDZPS-UHFFFAOYSA-N INCHI 1S/C18H14N4/c1-12-5-4-8-17(21-12)18-15(11-20-22-18)13-9-10-19-16-7-3-2-6-14(13)16/h2-11H,1H3,(H,20,22) Isómeros SMILES CC1=NC(=CC=C1)C2=C(C=NN2)C3=CC=NC4=CC=CC=C34 Peso molecular 286.33 Reaxy-Rn 32705446 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32705446&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Clase Quinolines and derivatives Subclass Not available Intermediate Tree Nodes Not available Direct Parent Quinolines and derivatives Alternative Parents Methylpyridines Benzenoids Pyrazoles Heteroaromatic compounds Azacyclic compounds Organonitrogen compounds Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents Quinoline - Methylpyridine - Benzenoid - Pyridine - Heteroaromatic compound - Pyrazole - Azole - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteropolycyclic compound Descripción This compound belongs to the class of organic compounds known as quinolines and derivatives. These are compounds containing a quinoline moiety, which consists of a benzene ring fused to a pyrimidine ring to form benzo[b]azabenzene. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Solubilidad Solvent:DMSO, Max Conc. mg/mL: 28.63, Max Conc. mM: 100; Solvent:1eq. HCl, Max Conc. mg/mL: 14.32, Max Conc. mM: 50 Peso molecular 286.300 g/mol XLogP3 3.100 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3 Rotatable Bond Count 2 Exact Mass 286.122 Da Monoisotopic Mass 286.122 Da Topological Polar Surface Area 54.500 Ų Heavy Atom Count 22 Formal Charge 0 Complexity 374.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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