Abemaciclib metabolite M18 hydrochloride - ≥98% , CAS No.A658656

CAS: A658656 Cat. No.: A658656 Peso molecular: 531

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Descripción general

Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib ( HY-16297A ), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader

Appearance:Solid

IC50& Target:CDK4 CDK6

In Vitro:Abemaciclib metabolite M18 hydrochloride exhibits T 1/2 of 43.1 hr in plasma in healthy subjects. CDK4/6 inhibitors’ chief mechanism of action is inhibition of retinoblastoma (RB) protein phosphorylation and thus the induction of cell cycle arrest, C

In Vivo:CDK4/6 inhibitors results T-cell persistence and immunologic memory increasing in mice receiving tumor-specific CD8 + T cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Biological Activity:Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib ( HY-16297A ), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader

Specifications

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Desiccated

Enviado en

Wet ice

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Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Peso molecular: 531

Propiedades químicas y físicas

• Solubilidad: DMSO : 125 mg/mL (235.40 mM; Need ultrasonic) H2O : 100 mg/mL (188.32 mM; Need ultrasonic)