ABMA - 10mM in DMSO , CAS No.332108-65-3

CAS: 332108-65-3 Cat. No.: A656205 Peso molecular: 350.29 PubChem CID: 2853512

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses , intracellular bacteria and parasite . ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity

In Vitro

ABMA protects cells against four bacterial toxins ( Corynebacterium diphtheriae (DT; EC 50 of 62.9 μM), Bacillus anthracis (LT), Clostridium difficile toxin B (TcdB; EC 50 of 73.3 µM), Clostridium sordellii lethal toxin (TcsL; EC 50 of 86.7 μM)), three viruses (Ebola (EC 50 of 3.3 µM), rabies (EC 50 of 19.4 µM), dengue-4 virus ( EC 50 of 8.2 µM)), two species of Chlamydiales intracellular bacteria ( Simkania negevensis and Chlamydia trachomatis ), and the parasite Leishmania infantum (EC 50 of 7.1 µM) at micromolar level. In A549 cells, ABMA treatment induces a decrease in ricin cytotoxicity with an EC 50 of 3.8 µM, and a protection factor (R) at 30 µM ranging from 5 to 10. ABMA retained almost 100% of its biological activity against ricin-induced cytotoxicity up to six days. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ABMA (2-200 mg/kg; intraperitoneal injection; female BALB/c mice) treatment protects mice from nasal instillation of an LD 90 of ricin . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Pathogen-free female BALB/c mice (6 week-old) with ricin Dosage: 2 mg/kg, 20 mg/kg, 200 mg/kg Administration: Intraperitoneal injection Result: A statistically significant protection according to survival curves was observed with a single ip dose of 2 mg/kg. The 20 mg/kg dose fully protected animals through to day 21. The 200 mg/kg dose resulted in 80% of protection of mice against ricin challenge with a single animal succumbing on day 15.

IC50& Target:Intracellular bacteria, Viruses, Parasite

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses , intracellular bacteria and parasite . ABMA selectively acts at host cell late endosomes rath

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: COC1=C(C=C(C=C1)Br)CNC23CC4CC(C2)CC(C4)C3
• PubChem CID: 2853512
• Peso molecular: 350.29