10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 27 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Acebutolol is aβ-adrenergic receptorsantagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.
In vitro
Acebutolol inhibits NA uptake in rat brain P2 fractions with IC50 of 0.25 mM. Acebutolol produces a concentration-dependent inhibition of 125I-labeled CYP binding to human fat cell membranes and are able to completely displace all specifically bound radioligand. Acebutolol totally inhibits lipolytic activity initiated by 1 μM isoproterenol. Acebutolol is a cardioselective antagonist possessing low lipid solubility. Acebutolol, which does not bind to LDL, shows a stronger inhibiting effect on the intracellular accumulation of cholesterol esters in J774 macrophages than alprenolol and oxprenolol which bind to LDL.
In vivo
Acebutolol following single intravenous administration (10 mg/kg) to rat results in the plasma clearance of 61.9\u2009mL/min/kg, the volume of distribution of 9.6\u2009L/kg, and an elimination half-life of 1.8\u2009hours. Acebutolol following single intravenous administration (50 mg/kg) to rat results in the plasma clearance of 46.5\u2009mL/min/kg, the volume of distribution of 9.5\u2009L/kg, and an elimination half-life of 2.3\u2009hours. Acebutolol (30 mg/kg) decreases cardiac output by 65% and 31% after 1 min and 10 min measurements, respectively, in Sprague-Dawley rats. Acebutolol (30 mg/kg) significantly reduces regional blood flow (RBF) in most organs either after 1 min or 10 min measurements when compare with the baseline values in Sprague-Dawley rats.
Cell Data
cell lines：RS4;11, MV4;11, and OC1-AML5
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isómeros SMILES | CCCC(=O)NC1=CC(=C(C=C1)OCC(CNC(C)C)O)C(=O)C.Cl |
|---|---|
| WGK Alemania | 3 |
| RTECS | ES5235000 |
| Peso molecular | 372.89 |
| Reaxy-Rn | 6080568 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6080568&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubilidad | Solubility (25°C) In vitro Water: 1 mg/mL (6.05 mM); DMSO: Insoluble; Ethanol: Insoluble; |
|---|---|
| Punto de fusión (°C) | 143-145°C |
| 1. Qianqian Liu, Qi Chen, Wenhao Zhang, Ru Liu, Dingxuan Li, Qingcui Chu. (2025) Zeolite imidazolate framework-67 reinforced hollow-fiber liquid-phase microextraction of typical flavor enhancers in dairy products followed by electrophoretic analysis. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, [PMID:] [10.1016/j.jfca.2025.108146] |
| 2. Huang Jialu, Zhang Shuchi, Tan Mengyu, Shen Jie, Zhao Haiyan, Wu Donglei. (2023) Occurrence, removal, and risk assessment of emerging contaminants in aquatic products processing sewage treatment plants. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, [PMID:37874520] [10.1007/s11356-023-30458-z] |
| 3. Dingxiang Wang, Yongqiang Yu, Jiahao He, Jun Ma, Jing Zhang, Timothy J. Strathmann. (2023) Comprehending the practical implementation of permanganate and ferrate for water remediation in complex water matrices. JOURNAL OF HAZARDOUS MATERIALS, [PMID:37820527] [10.1016/j.jhazmat.2023.132659] |
| 4. Xiaoyan Ma, Sinong Huang, Yuhong Jin, Hui Liao, Shaoning Chen, Hong Wang, Weijie Zhang, Yifei Wu, Weiwei Bi, Xueyan Li, Andrea M. Dietrich. (2023) Domesticating aquatic plants in hydroponic systems to demonstrate and advance phytoremediation of the artificial sweetener acesulfame. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:37308013] [10.1016/j.scitotenv.2023.164806] |
| 5. Yang Yue, Li Li, Baocheng Qu, Ying Liu, Xuankai Wang, Houyu Wang, Siyu Chen. (2023) Levels, consumption, and variations of eight artificial sweeteners in the wastewater treatment plants of Dalian city, China. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:37201820] [10.1016/j.scitotenv.2023.163867] |
| 6. Long Su, Fei Lu, Yanrui Li, Xia Li, Liangdan Chen, Yanan Gao, Liqiang Zheng, Xinpei Gao. (2023) Microstructural Evolution of Zinc-Ion Species from Aqueous to Hydrated Eutectic Electrolyte for Zn-Ion Batteries. ChemSusChem, 16 (14): (e202300285). [PMID:37010877] [10.1002/cssc.202300285] |
| 7. Yuanyuan Cao, Shuyi Shan, Yitong Lu, Jialu Luo, Yilin Li, Rongzhang Hao. (2022) Tuning toxic properties of polyethylene glycol-based deep eutectic solvents for achieving greener solvents. JOURNAL OF MOLECULAR LIQUIDS, [PMID:] [10.1016/j.molliq.2022.120879] |
| 8. Qinghao Cao, Chao Chen, Jun Huang, Dantong Shen, Haolin Chen, Huiqing Zhong, Zhiming Liu, Zhouyi Guo. (2022) Mussel-inspired hydrogels for fast fabrication of flexible SERS tape for point-of-care testing of β-blockers. ANALYST, 147 (16): (3652-3661). [PMID:35839093] [10.1039/D2AN00688J] |
| 9. Decheng Zhang, Xiudan Lang, Ni Hui, Jiasheng Wang. (2022) Dual-Mode electrochemical biosensors based on Chondroitin sulfate functionalized polypyrrole nanowires for ultrafast and ultratrace detection of acetamiprid pesticide. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2022.107530] |
| 10. Hengyu Cai, Jing Zou, Jinbin Lin, Jiawen Li, Yixin Huang, Shuyin Zhang, Baoling Yuan, Jun Ma. (2021) Sodium hydroxide-enhanced acetaminophen elimination in heat/peroxymonosulfate system: Production of singlet oxygen and hydroxyl radical. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2021.132438] |
| 11. Jiayang Zhang, Xiwen Ma, Xueping Dang, Huaixia Chen, Yuling Hu. (2021) Adsorption mechanism of polycyclic aromatic hydrocarbons on polythiophene-graphene covalent complex and its analytical application in food contact materials. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2021.106767] |
| 12. Zhe Wang, Wei Sun, Zheng-Feng Lin, Rui Sun, Cheng-Ke Huang, Wei-Jian Ye, Yao-Yao Dong, Xiao-Dan Zhang, Rui-Jie Chen. (2018) A UHPLC-MS/MS method coupled with liquid-liquid extraction for the quantitation of phenacetin, omeprazole, metoprolol, midazolam and their metabolites in rat plasma and its application to the study of four CYP450 activities. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, [PMID:30317077] [10.1016/j.jpba.2018.10.012] |
| 13. Yan Kang, Huijun Xie, Bo Li, Jian Zhang, Huu Hao Ngo, Wenshan Guo, Zizhang Guo, Qiang Kong, Shuang Liang, Jie Liu, Tingting Cheng, Liwei Zhang. (2018) Performance of constructed wetlands and associated mechanisms of PAHs removal with mussels. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2018.09.152] |
| 14. Li Yuhong, Wang Mingshi, Zhang Dong. (2024) An improved method for isotopic and quantitative analysis of dissolved organic carbon in natural water samples. WATER SCIENCE AND TECHNOLOGY, 89 (8): (2060-2072). [PMID:38678409] [10.2166/wst.2024.114] |
| 15. Xun Guo, Hu Hong, Qing Li, Jiaxiong Zhu, Zhuoxi Wu, Yanbo Wang, Shuo Yang, Zhaodong Huang, Yan Huang, Nan Li, Chunyi Zhi. (2024) Dual robust electrode-electrolyte interfaces enabled by fluorinated electrolyte for high-performance zinc metal batteries. Matter, [PMID:] [10.1016/j.matt.2024.08.002] |
| 16. Yao Li, Jiyuan Tu, Hong Wang, Kexin Luo, Pingping Xiao, Tangbin Liao, Guo-Jun Zhang, Zhongyue Sun. (2025) Dual signal output detection of acetamiprid residues in medicine and food homology products via nanopore biosensor. FOOD CHEMISTRY, [PMID:40157106] [10.1016/j.foodchem.2025.144030] |
| 17. Chen-Yan Hu, Xin-Yu Yang, Li-Li Hu, Hao Liu, Jia-Nan Chen, Ling-Mei Gao, Zheng-Yu Dong. (2025) Role of S(IV) in enhancing permanganate oxidation of emerging contaminants: pH dependence of reactive species generation. Journal of Environmental Chemical Engineering, [PMID:] [10.1016/j.jece.2025.115365] |
| 18. Xun Guo, Junfeng Lu, Mi Wang, Ao Chen, Hu Hong, Qing Li, Jiaxiong Zhu, Yanbo Wang, Shuo Yang, Zhaodong Huang, Yanlei Wang, Zengxia Pei, Chunyi Zhi. (2024) Solid-electrolyte interphase governs zinc ion transfer kinetics in high-rate and stable zinc metal batteries. Chem, [PMID:] [10.1016/j.chempr.2024.07.028] |
| 19. Mingsha Jie, Amei Zhu, Bing Zhu, Jiaxin He, Shengkai Lan, Xingang Lang, Yanhong Bai. (2025) A ratiometric fluorescent sensor based on AIE nanoparticles and nitrogen-doped carbon dots for rapid and sensitive detection of acetamiprid in rice. NEW JOURNAL OF CHEMISTRY, [PMID:] [10.1039/D5NJ00612K] |
| 20. Ru Yin, Mingdong Chang, Rui Ma, Jianqiao Wang, Nana Wang, Tangfu Xiao, Hirofumi Hirai. (2025) Insights into the Imidaclothiz Biodegradation by the White-Rot Fungus Phanerochaete sordida YK-624 under Ligninolytic Conditions. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:40360430] [10.1021/acs.jafc.5c01521] |
| 21. Yan Yang, Shuojie Wang, Wenxin Mai, Shiyu Wei, Guixiang Teng, Peng Pu, Jiaxing Zhao, Yongqiang Tian. (2025) Unique Design of Functionalized Covalent Organic Frameworks for Highly Selective Removal of Cyano-Neonicotinoids. Nanomaterials, 15 (20): (1596). [PMID:41149564] [10.3390/nano15201596] |
| 22. Tingting Zhou, Biao Zhang, Xuan Xie, Yuanxi Liu, Hailiang Li, Hongyu Jin, Yongqiang Lin, Feng Wei, Ying Wang. (2025) Construction and Application of Indirect Competitive Enzyme-Linked Immunosorbent Assay for Acetamiprid in Traditional Chinese Medicine. Toxics, 13 (11): (982). [PMID:41304534] [10.3390/toxics13110982] |
| 23. Chenyu Wu, Chang Zhang, Chuxin Liao, Lin Lyv, Lingyun Chen, Fengfeng Wang, Zhengzheng Zhou. (2026) Polymorphic Cocrystallization: Substantially enhancing aceclofenac solubility across diverse pH conditions. JOURNAL OF MOLECULAR STRUCTURE, [PMID:] [10.1016/j.molstruc.2026.145434] |
| 24. Zhang Yanjiao, Guo Yanxian, Wang Wen, Fang Xianglin, Cong Yanguang, Li Shaoxin. (2026) Machine learning-assisted wearable SERS-microfluidic system for rapid detection of sweat biomarkers and stimulants. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, [PMID:41673135] [10.1007/s00216-026-06347-y] |
| 25. Yong-mei Zhang, Ping-ping Fan, Ling-zhi Zhang, Wei Yu, Song Xia, Fa-li Liu, Xue-de Li. (2026) Occurrence, ecological risk, and human health assessment of herbicide residues in Chaohu Lake, China. Journal of Environmental Chemical Engineering, 14 (2): (121850). [PMID:] [10.1016/j.jece.2026.121850] |
| 26. Minghua Nie, Meiqi Su, Yue Zhang, Yuyan Liu, Caixia Yan. (2026) Degradation of acetaminophen in fresh urine by periodate: Mechanisms, influencing factors and toxicity assessment. Environmental Technology & Innovation, [PMID:] [10.1016/j.eti.2026.104850] |
| 27. Lingling Yang, Shuxian Zhang, Xiaoxuan Fan, Keshuai Liu, Rui Mai, Wangyan Zhao, Qiang Han, Yongjian Ai, Qionglin Liang, Xueqin Ma, Guoning Chen. (2026) Rapid and Sensitive Screening of Carbonic Anhydrase Natural Inhibitors in Traditional Chinese Medicine via a Carbon Quantum Dot-Affinity Adsorption Nanosystem. Journal of Pharmaceutical Analysis, [PMID:] [10.1016/j.jpha.2026.101607] |
