≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
ACH-000143 is a potent and orally active melatonin receptor agonist, with EC 50 values of 0.06 nM and 0.32 nM for MT1 and MT2 , respectively
In Vivo
ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats . ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate . ACH-000143 significantly reduces plasma glucose at 10 mg/kg (−16.4%, p < 0.05) and 30 mg/kg (−16.9%, p < 0.01) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: High-fat diet rats . Dosage: 10 and 30 mg/kg. Administration: Orally, once daily for two months. Result: Significantly reduced the weekly BW gain on weeks.
Form:Solid
IC50& Target:MT1 0.06 nM (EC 50 ) MT2 0.32 nM (EC 50 )
| Sonrisas canónicas | CC(=O)NCCN1C2=CC(=C(C=C2N=C1OC)Cl)OC |
|---|---|
| IUPAC Name | N-[2-(5-chloro-2,6-dimethoxybenzimidazol-1-yl)ethyl]acetamide |
| InChIKey | BVSLRGAPRGQWNC-UHFFFAOYSA-N |
| INCHI | 1S/C13H16ClN3O3/c1-8(18)15-4-5-17-11-7-12(19-2)9(14)6-10(11)16-13(17)20-3/h6-7H,4-5H2,1-3H3,(H,15,18) |
| Isómeros SMILES | CC(=O)NCCN1C2=CC(=C(C=C2N=C1OC)Cl)OC |
| PubChem CID | 139451790 |
| Peso molecular | 297.74 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Solubilidad | DMSO : 50 mg/mL (167.93 mM; Need ultrasonic) |
|---|
