Aciclovir (BW 248U) - Moligand™, 10mM in DMSO , Human herpesvirus 1 DNA polymerase inhibitor, CAS No.59277-89-3, Human herpesvirus 1 DNA polymerase inhibitor

CAS: 59277-89-3 Cat. No.: A407837 Peso molecular: 225.2 Número EC: 261-685-1

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011 | 2-​amino-​1,​9-​dihydro-​9-​[(2-​hydroxyethoxy)​methyl]​-6H-​purin-​6-​one

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Aciclovir (BW 248U) Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.
In vitro

Acyclovir sensitivity of herpes simplex virus isolates is determined in a plaque-reduction assay in Vero cells. IC50 Values are consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains are 2-10-fold less sensitive than Type 1 strains.

In vivo

low-dose oral acyclovir may be effective in the prevention of HSV infection during OKT3 treatment of seropositive patients. Continuation of acyclovir prophylaxis for two to four weeks following the conclusion of OKT3 therapy may prevent occurrence of delayed infections.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011 | 2-​amino-​1, ​9-​dihydro-​9-​[(2-​hydroxyethoxy)​methyl]​-6H-​purin-​6-​one

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Human herpesvirus 1 DNA polymerase inhibitor

Nombres e identificadores

• Isómeros SMILES: C1=NC2=C(N1COCCO)N=C(NC2=O)N
• WGK Alemania: 2
• RTECS: UP0791400
• Peso molecular: 225.2
• Reaxy-Rn: 1219402
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1219402&ln=

Propiedades químicas y físicas

• Punto de fusión (°C): 262°C

Referencias

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