Acitretin - Moligand™, 10mM in DMSO , Retinoid receptor agonist, CAS No.55079-83-9, Retinoid receptor agonist

CAS: 55079-83-9 Cat. No.: A408623 Peso molecular: 326.43 Número EC: 259-474-4

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Etretin, RO 10-1670 | (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Acitretin Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.
In vitro

Acitretin stimulates ADAM10 promoter activity with an EC(50) of 1.5 mM and leads to an increase of mature ADAM10 protein that results in a two- to three-fold increase of the ratio between alpha- and beta-secretase activity in neuroblastoma cells. Acitretin (5-20 μM) impairs mitochondrial phosphorylation efficiency as demonstrated by the decrease in the state 3 respiration and ATP levels, and by the increase in the lag phase of ADP phosphorylation cycle, without affecting the membrane potential. Acitretin induces Ca(2+)-mediated mitochondrial permeability transition (MPT) and decreased the adenine nucleotide translocase (ANT) content. Acitretin preferentially inhibits the growth of SCL-1 cells in a dose- and time-dependent manner, but not of non-malignant keratinocyte HaCaT cells. Acitretin increases the levels of CD95 (Fas), CD95-ligand and Fas-associated death domain. Acitretin is able to induce apoptosis in skin cancer cells possibly via death receptor CD95 apoptosis pathway without affecting the viability of normal keratinocyte.

In vivo

Acitretin undergoes alpha-oxidation, chain shortening O-demethylation, and glucuronidation in the perfused rat liver. Acitretin rapidly appears in liver and muscle of rats, where it undergoes redistribution into skin and adipose tissue.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥95%

Specifications

Sinónimos

Etretin, RO 10-1670 | (2E, 4E, 6E, 8E)-9-(4-methoxy-2, 3, 6-trimethylphenyl)-3, 7-dimethylnona-2, 4, 6, 8-tetraenoic acid

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

AGONIST

Mecanismo de acción

Retinoid receptor agonist

Nombres e identificadores

• Isómeros SMILES: CC1=CC(=C(C(=C1/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C)C)C)OC
• WGK Alemania: 3
• Número ONU: 3077
• Peso molecular: 326.43
• Reaxy-Rn: 15057225
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=15057225&ln=

Propiedades químicas y físicas

• Punto de fusión (°C): 230 °C

Referencias

1. Yongjie Bao, Wenni Rong, An Zhu, Yuan Chen, Huiyue Chen, Yirui Hong, Jingyang Le, Qiyao Wang, C. Benjamin Naman, Zhipeng Xu, Lin Liu, Wei Cui, Xiang Wu.  (2023)  Retinoic Acid Receptor Is a Novel Therapeutic Target for Postoperative Cognitive Dysfunction.  Pharmaceutics,  15  (9): (2311).  [PMID:37765280] [10.3390/pharmaceutics15092311]