Acridine-3,6-diamine - 10mM in DMSO , DNA disrupting agent, CAS No.92-62-6, DNA disrupting agent

CAS: 92-62-6 Cat. No.: A426953 Peso molecular: 209.25 Número EC: 202-172-4

GRADE & PURITY 10mM in DMSO

Synonyms

AE-562/12222295 | Progarmed | CCRIS 1244 | HY-B1741 | YSCH0132 | 3,6-ACRIDINEDIAMINE | A909942 | AI3-52128 | NCI60_004643 | Proflavin hemisulfate;3,6-Diaminoacridine hemisulfate | Q420454 | 1qvt | 2,8-Diaminoacridine (European) | AT13412 | AB00375967_04 |

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Maximum Absorption Wavelength:444(H2O)nm

Specifications

Sinónimos

AE-562/12222295 | Progarmed | CCRIS 1244 | HY-B1741 | YSCH0132 | 3, 6-ACRIDINEDIAMINE | A909942 | AI3-52128 | NCI60_004643 | Proflavin hemisulfate;3, 6-Diaminoacridine hemisulfate | Q420454 | 1qvt | 2, 8-Diaminoacridine (European) | AT13412 | AB00375967_04 |

Especificaciones y pureza

10mM in DMSO

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

DISRUPTING AGENT

Mecanismo de acción

DNA disrupting agent

Nombres e identificadores

• Sonrisas canónicas: C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N
• IUPAC Name: acridine-3,6-diamine
• InChIKey: WDVSHHCDHLJJJR-UHFFFAOYSA-N
• INCHI: 1S/C13H11N3/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10/h1-7H,14-15H2
• Isómeros SMILES: C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N
• RTECS: AR8670000
• Peso molecular: 209.25
• Reaxy-Rn: 166050
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=166050&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Quinolines and derivatives
      • Subclass Benzoquinolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Quinolines and derivatives
• Subclass: Benzoquinolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Acridines
• Alternative Parents: Aminoquinolines and derivatives Pyridines and derivatives Benzenoids Heteroaromatic compounds Azacyclic compounds Primary amines Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Acridine - Aminoquinoline - Benzenoid - Pyridine - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Primary amine - Organonitrogen compound - Amine - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as acridines. These are organic compounds containing the acridine moiety, a linear tricyclic heterocycle which consists of two benzene rings joined by a pyridine ring.
• External Descriptors: aminoacridines

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

F2 Tclin Thrombin (11687 Activities)

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ESR1 Tclin Estrogen receptor alpha (17718 Activities)

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PGR Tclin Progesterone receptor (8562 Activities)

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

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ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

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AR Tclin Androgen Receptor (11781 Activities)

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CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

VDR Tclin Vitamin D receptor (26531 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAOA Tclin Monoamine oxidase A (11911 Activities)

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DRD1 Tclin Dopamine D1 receptor (9720 Activities)

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ACHE Tclin Acetylcholinesterase (18204 Activities)

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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

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SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

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SLC6A4 Tclin Serotonin transporter (12625 Activities)

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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

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OPRM1 Tclin Mu opioid receptor (19785 Activities)

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DRD3 Tclin Dopamine D3 receptor (14368 Activities)

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SLC6A3 Tclin Dopamine transporter (10535 Activities)

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KCNH2 Tclin HERG (29587 Activities)

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PDE3A Tclin Phosphodiesterase 3A (3309 Activities)

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HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)

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TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)

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PDE4A Tclin Phosphodiesterase 4A (1943 Activities)

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ADORA3 Tchem Adenosine A3 receptor (15931 Activities)

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HRH3 Tclin Histamine H3 receptor (10389 Activities)

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KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

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TERT Tchem Telomerase reverse transcriptase (2428 Activities)

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THP-1 (11052 Activities)

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A549 (127892 Activities)

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A2780 (11979 Activities)

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POLK Tbio DNA polymerase kappa (8653 Activities)

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HTT Tchem Huntingtin (19182 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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LMNA Tbio Prelamin-A/C (36751 Activities)

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GMNN Tbio Geminin (128009 Activities)

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PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

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KMT2A Tchem Histone-lysine N-methyltransferase MLL (17327 Activities)

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HSPA5 Tchem 78 kDa glucose-regulated protein (3319 Activities)

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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

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CTRC Tchem Chymotrypsin (134 Activities)

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Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

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Escherichia coli (133304 Activities)

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Streptococcus pyogenes (16140 Activities)

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Leishmania infantum (5912 Activities)

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Trypanosoma brucei (78846 Activities)

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Plasmodium falciparum (966862 Activities)

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Human immunodeficiency virus 1 (70413 Activities)

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CHO (4503 Activities)

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CHO-K1 (1115 Activities)

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L1210 (27553 Activities)

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Vero (26788 Activities)

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Calf thymus DNA (4845 Activities)

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GCN5 Histone acetyltransferase GCN5 (89 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Rorc Nuclear receptor ROR-gamma (89407 Activities)

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BETVIA Major pollen allergen Bet v 1-A (2 Activities)

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Middle East respiratory syndrome-related coronavirus (220 Activities)

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SARS-CoV-2 (38078 Activities)

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Vero C1008 (1716 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Sensibilidad: Air Sensitive
• Punto de fusión (°C): 280 °C(dec.)
• Peso molecular: 209.250 g/mol
• XLogP3: 1.800
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 209.095 Da
• Monoisotopic Mass: 209.095 Da
• Topological Polar Surface Area: 64.900 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 232.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Chen Jiaxin, Hu Yongjun, Lu Qiao, Wang Pengchao, Zhan Huaqi.  (2017)  Determination of proflavine in rat whole blood without sample pretreatment by laser desorption postionization mass spectrometry.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  409  (11): (2813-2819).  [PMID:28188352] [10.1007/s00216-017-0225-x]

2. Jianliang Xiao, Jifei Zhang, Weiyang Lv, Yihu Song, Qiang Zheng.  (2017)  Multifunctional graphene/poly(vinyl alcohol) aerogels: In situ hydrothermal preparation and applications in broad-spectrum adsorption for dyes and oils.  CARBON,      [PMID:] [10.1016/j.carbon.2017.07.049]