GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.10mM in DMSO
Moligand™,10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Argon charged,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC 50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy
In Vitro
Treatment with ACY-1083 (30 and 300 nM) significantly improves cell viability in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Mouse hippocampal (HT22) cells Concentration: 30 and 300 nM Incubation Time: Result: Significant improvement in cell viability.
In Vivo
ACY-1083 (i.p.; 10 mg/kg; for 7 days) effectively relieves Cisplatin-induced mechanical allodynia in C57BL/6J mice ACY-1083 (oral doses of 3 mg/kg ACY-1083 for 7 days) reverses Paclitaxel-induced mechanical allodynia in adult male SD rats. Mice dosed with 5 mg/kg ACY-1083 by intraperitoneal (i.p.) injection have a maximum plasma concentration (C max ) of 936 ng/mL, a half-life (T 1/2 ) of 3.5 hours, and a biologically active plasma exposure of 8 hours after dosing. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult male C57BL/6J mice of 8-10 weeks of age Dosage: 3 or 10 mg/kg Administration: Administered i.p. injection; daily; for 7 days Result: The 10 mg/kg relieved Cisplatin (2.3 mg/kg)-induced mechanical allodynia, whereas the 3 mg/kg dose did not. Animal Model: Adult male Sprague Dawley rats Dosage: 3 mg/kg Administration: Two daily doses were given orally for 7 days. Result: Reversed Paclitaxel (6 mg/kg or 12 mg/kg)-induced mechanical allodynia.
IC50& Target:HDAC6 3 nM (IC 50 )
Specifications
Especificaciones y pureza
Moligand™, 10mM in DMSO
Mecanismos bioquímicos y fisiológicos
ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC 50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy.
Condiciones de almacenamiento de almacenamiento
Argon charged, Store at -80°C
Enviado en
Dry ice packs + Cold packs
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Tipo de acción
INHIBITOR
Nombres e identificadores
Isómeros SMILES
C1CC(CCC1(C2=CC=CC=C2)NC3=NC=C(C=N3)C(=O)NO)(F)F
PubChem CID
91844718
Peso molecular
348.35
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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