Adefovir Dipivoxil (GS 0840) - Moligand™,10mM in DMSO , CAS No.142340-99-6

CAS: 142340-99-6 Cat. No.: A409177 Peso molecular: 501.47 Número EC: 634-317-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

1,​1'-​[[[[2-​(6-​amino-​9H-​purin-​9-​yl)​ethoxy]​methyl]​phosphinylidene]​bis(oxymethylene)​]-2,​2-​dimethyl-propanoic acid ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Adefovir Dipivoxil (GS 0840) Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).
In vitro

In vivo

Adefovir Dipivoxil reduces Liver HBV DNA to <0.1 pg of viral DNA per mg of total DNA (pg/mg) in transgenic mice expressing hepatitis B virus. Adefovir Dipivoxil treatment also reduces serum HBV DNA to 3.5 log10 genomic equivalents (ge)/mL in transgenic mice expressing hepatitis B virus compared to 5.3 log10 ge/mL for the placebo control group. Adefovir Dipivoxil antiviral activity reaches near maximum viral reduction by day 10 in the liver and reaches an endpoint of liver virus inhibition at 1.0 mg/kg/day.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

1, ​1'-​[[[[2-​(6-​amino-​9H-​purin-​9-​yl)​ethoxy]​methyl]​phosphinylidene]​bis(oxymethylene)​]-2, ​2-​dimethyl-propanoic acid ester

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Propiedades del producto

• ALogP: 1.8

Nombres e identificadores

• Isómeros SMILES: CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N=CN=C21)N)OCOC(=O)C(C)(C)C
• WGK Alemania: 3
• RTECS: UA2459362
• Peso molecular: 501.47
• Reaxy-Rn: 7060608
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7060608&ln=

Propiedades químicas y físicas

• Punto de fusión (°C): 101 °C

Referencias

1. Yuehua Yu, Zixuan Li, Yuan He, Ji Huang, Zhenxiao Sun.  (2026)  Repositioning of nonsedating antihistamine Ebastine for anti-lung adenocarcinoma based on EGFR/ERBB2 dual-targeting strategy.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:] [10.1016/j.ejphar.2026.178774]